{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:32:31Z","timestamp":1787070751808,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mastoid signal changes on magnetic resonance imaging in cerebral venous sinus thrombosis (CVT) patients are often misinterpreted as septic CVT. Studies have revealed mastoid signal changes in CVT patients. We conducted this study to investigate this relationship. Single-center, retrospective, observational study. Patients aged \u226518 years with venography-proven CVT were enrolled, excluding those with sepsis-induced CVT. Mastoid changes and clot burden score (CBS) were calculated. We screened and enrolled 128 and 124 CVT patients, respectively. Seventy per cent of patients had mastoid signal changes. The median mastoid score and CBS were 1 and 3, respectively. CBS was higher in CVT patients with mastoid changes. A higher CBS was associated with a higher mastoid score (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.003). Logistic regression analysis revealed an odds ratio of 0.67 (95% confidence interval: 0.52\u20130.87) for this association. The presence of radiological mastoid involvement is not sine qua non of associated middle ear infections and should raise the possibility of CVT.\n                  <\/jats:p>","DOI":"10.4103\/aian.aian_99_25","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T12:00:17Z","timestamp":1751889617000},"page":"729-733","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Mastoid Signal Change and Acute Cerebral Venous Sinus Thrombosis: Unlocking the Puzzle"],"prefix":"10.4103","volume":"28","author":[{"given":"Ayush","family":"Agarwal","sequence":"first","affiliation":[{"name":"Department of Neurology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venugopalan Y","family":"Vishnu","sequence":"additional","affiliation":[{"name":"Department of Neurology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meena","family":"Chandu","sequence":"additional","affiliation":[{"name":"Department of Neurology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divyani","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Neurology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjari","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Applied Maths and Theoretical Physics, University of Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjot","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Neurology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maneesh","family":"Shakywar","sequence":"additional","affiliation":[{"name":"Department of Neurology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Department of Neurology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achal K","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Neurology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Upadhyay","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Neuroimaging and Interventional Neuroradiology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MV Padma","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Neurology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"R1-20251112","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1161\/01.STR.0000117571.76197.26","article-title":"Prognosis of cerebral vein and dural sinus thrombosis","volume":"35","author":"Ferro","year":"2004","journal-title":"Stroke"},{"key":"R2-20251112","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1161\/STROKEAHA.107.509711","article-title":"Isolated lateral sinus thrombosis","volume":"40","author":"Damak","year":"2009","journal-title":"Stroke"},{"key":"R3-20251112","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jocn.2023.09.007","article-title":"Mastoid fluid signal in acute cerebral venous thrombosis is associated with increased clot burden","volume":"117","author":"Govind","year":"2023","journal-title":"J Clin Neurosci"},{"key":"R4-20251112","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1161\/hs0102.101016","article-title":"Mastoid air sinus abnormalities associated with lateral venous sinus thrombosis","volume":"33","author":"Fink","year":"2002","journal-title":"Stroke"},{"key":"R5-20251112","doi-asserted-by":"crossref","first-page":"406","DOI":"10.2214\/AJR.12.9442","article-title":"Mastoid findings secondary to posterior fossa dural venous sinus thrombosis","volume":"201","author":"Shah","year":"2013","journal-title":"Am J Roentgenol"},{"key":"R6-20251112","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00330-004-2505-z","article-title":"Mastoid effusion associated with dural sinus thrombosis","volume":"15","author":"Agid","year":"2005","journal-title":"Eur Radiol"},{"key":"R7-20251112","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jocn.2022.08.022","article-title":"Predicting poor response to anti-coagulation therapy in cerebral venous thrombosis using a simple clinical-radiological score","volume":"105","author":"Montalvan","year":"2022","journal-title":"J Clin Neurosci"},{"key":"R8-20251112","doi-asserted-by":"crossref","first-page":"640","DOI":"10.3340\/jkns.2020.0067","article-title":"Relationship between increased intracranial pressure and mastoid effusion","volume":"63","author":"Jung","year":"2020","journal-title":"J Korean Neurosurg Soc"},{"key":"R9-20251112","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s00405-018-5197-8","article-title":"Fluid signal in the mastoid is a common incidental finding on MRI of the brain","volume":"276","author":"Gossner","year":"2019","journal-title":"Eur Arch Otorhinolaryngol"}],"container-title":["Annals of Indian Academy of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aian.aian_99_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:36:00Z","timestamp":1787067360000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aian.aian_99_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,7]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/aian.aian_99_25","relation":{},"ISSN":["0972-2327","1998-3549"],"issn-type":[{"value":"0972-2327","type":"print"},{"value":"1998-3549","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,7]]},"assertion":[{"value":"2025-02-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-17","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}