{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:14:02Z","timestamp":1792800842440,"version":"4.5.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian J Androl"],"published-print":{"date-parts":[[2019]]},"DOI":"10.4103\/aja.aja_110_18","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T01:48:58Z","timestamp":1551145738000},"page":"478","source":"Crossref","is-referenced-by-count":95,"title":["Heavy cigarette smoking and alcohol consumption are associated with impaired sperm parameters in primary infertile men"],"prefix":"10.4103","volume":"21","author":[{"given":"Andrea","family":"Salonia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Boeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Capogrosso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Ventimiglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Pederzoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Cazzaniga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Chierigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Deh\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Montanari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Montorsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/1008-682X.253097-1","unstructured":"World Health Organization. Prevalence of tobacco use. Available from: http:\/\/www.who.int\/gho\/tobacco\/use\/en\/. [Last accessed on 2018 May 07]."},{"key":"key-10.4103\/1008-682X.253097-2","first-page":"1554\u20139","article-title":"The impact of cigarette smoking on human semen parameters and hormones","author":"Trummer","year":"2002","journal-title":"Hum Reprod"},{"key":"key-10.4103\/1008-682X.253097-3","first-page":"143\u201360","article-title":"Smoking and male infertility: an evidence-based review","author":"Harlev","year":"2015","journal-title":"World J Mens Health"},{"key":"key-10.4103\/1008-682X.253097-4","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1477-7827-11-66","article-title":"Lifestyle factors and reproductive health: taking control of your fertility","author":"Sharma","year":"2013","journal-title":"Reprod Biol Endocrinol"},{"key":"key-10.4103\/1008-682X.253097-5","first-page":"564\u201371","article-title":"Cigarette smoke extract immobilizes human spermatozoa and induces sperm apoptosis","author":"Calogero","year":"2009","journal-title":"Reprod Biomed Online"},{"key":"key-10.4103\/1008-682X.253097-6","first-page":"281\u201391","article-title":"Cigarette smoking and reproductive function","author":"Soares","year":"2008","journal-title":"Curr Opin Obstet Gynecol"},{"key":"key-10.4103\/1008-682X.253097-7","first-page":"635\u201345","article-title":"Cigarette smoking and semen quality: a new meta-analysis examining the effect of the 2010 World Health Organization laboratory methods for the examination of human semen","author":"Sharma","year":"2016","journal-title":"Eur Urol"},{"key":"key-10.4103\/1008-682X.253097-8","doi-asserted-by":"crossref","first-page":"e12926","DOI":"10.1111\/and.12926","article-title":"Impact of alcohol and cigarette smoking consumption in male fertility potential: looks at lipid peroxidation, enzymatic antioxidant activities and sperm DNA damage","author":"Aboulmaouahib","year":"2018","journal-title":"Andrologia"},{"key":"key-10.4103\/1008-682X.253097-9","doi-asserted-by":"crossref","first-page":"e12910","DOI":"10.1111\/and.12910","article-title":"The effect of cigarette smoking on human seminal parameters, sperm chromatin structure and condensation","author":"Mostafa","year":"2018","journal-title":"Andrologia"},{"key":"key-10.4103\/1008-682X.253097-10","doi-asserted-by":"crossref","unstructured":"Swan SH, Brazil C, Drobnis EZ, Liu F, Kruse RL, et al. Geographic differences in semen quality of fertile U.S. males. Environ Health Perspect 2003; 111: 414\u201320.","DOI":"10.1289\/ehp.5927"},{"key":"key-10.4103\/1008-682X.253097-11","first-page":"459\u201369","article-title":"Semen quality of 1346 healthy men, results from the Chongqing area of Southwest China","author":"Li","year":"2009","journal-title":"Hum Reprod"},{"key":"key-10.4103\/1008-682X.253097-12","first-page":"919\u201324","article-title":"Effect of chronic alcoholism on male fertility hormones and semen quality","author":"Muthusami","year":"2005","journal-title":"Ferti Steril"},{"key":"key-10.4103\/1008-682X.253097-13","first-page":"558\u201363","article-title":"Semen analysis in alcohol dependence syndrome","author":"Kucheria","year":"1985","journal-title":"Andrologia"},{"key":"key-10.4103\/1008-682X.253097-14","first-page":"548\u201352","article-title":"The effect of alcohol, tobacco, and aspirin consumption on seminal quality among healthy young men","author":"Stutz","year":"2004","journal-title":"Arch Environ Health"},{"key":"key-10.4103\/1008-682X.253097-15","first-page":"135\u20138","article-title":"Semen quality and frequency of smoking and alcohol consumption \u2013 an explorative study","author":"Goverde","year":"1995","journal-title":"Int J Fertil Menopause Stud"},{"key":"key-10.4103\/1008-682X.253097-16","first-page":"777\u201382","article-title":"The impact of cigarette smoking and alcohol consumption on sperm parameters and sperm DNA fragmentation (SDF) measured by Halosperm(\u00ae)","author":"Anifandis","year":"2014","journal-title":"Arch Gynecol Obstet"},{"key":"key-10.4103\/1008-682X.253097-17","first-page":"18\u201325","article-title":"Diagnostic evaluation of the infertile male: a committee opinion","author":"Practice","year":"2015","journal-title":"Fertil Steril"},{"key":"key-10.4103\/1008-682X.253097-18","first-page":"935\u201350","article-title":"Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios","author":"Agarwal","year":"2016","journal-title":"Transl Androl Urol"},{"key":"key-10.4103\/1008-682X.253097-19","first-page":"456\u201367","article-title":"Reproductive outcomes of testicular versus ejaculated sperm for intracytoplasmic sperm injection among men with high levels of DNA fragmentation in semen: systematic review and meta-analysis","author":"Esteves","year":"2017","journal-title":"Fertil Steril"},{"key":"key-10.4103\/1008-682X.253097-20","first-page":"1314\u201321","article-title":"Lack of association between smoking and DNA fragmentation in the spermatozoa of normal men","author":"Sergerie","year":"2000","journal-title":"Hum Reprod"},{"key":"key-10.4103\/1008-682X.253097-21","unstructured":"World Health Organization. Infertility definitions and terminology. Available from: http:\/\/www.who.int\/reproductivehealth\/topics\/infertility\/definitions. [Last accessed on 2018 May 02]."},{"key":"key-10.4103\/1008-682X.253097-22","unstructured":"World Health Organization. WHO laboratory manual for the examination and processing of human semen. 5th ed. Geneva: World Health Organization; 2010."},{"key":"key-10.4103\/1008-682X.253097-23","first-page":"25\u201343","article-title":"Sperm chromatin structure assay: its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques","author":"Evenson","year":"2002","journal-title":"J Androl"},{"key":"key-10.4103\/1008-682X.253097-24","first-page":"373\u201383","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation","author":"Charlson","year":"1987","journal-title":"J Chronic Dis"},{"key":"key-10.4103\/1008-682X.253097-25","unstructured":"National Institute of Alcohol Abuse and Alcoholism. The Physicians' guide to helping patients with alcohol problems. Washington: U.S. Department of Health and Human Services, National Institutes of Health; 1995. p30."},{"key":"key-10.4103\/1008-682X.253097-26","first-page":"920\u20133","article-title":"When to perform karyotype analysis in infertile men.Validation of the European Association of Urology guidelines with the proposal of a new predictive model?","author":"Ventimiglia","year":"2016","journal-title":"Eur Urol"},{"key":"key-10.4103\/1008-682X.253097-27","first-page":"796\u2013808","article-title":"Varicocele and male factor infertility treatment: a new meta-analysis and review of the role of varicocele repair","author":"Baazeem","year":"2011","journal-title":"Eur Urol"},{"key":"key-10.4103\/1008-682X.253097-28","first-page":"371\u201389","article-title":"Dietary patterns, foods and nutrients in male fertility parameters and fecundability: a systematic review of observational studies","author":"Salas-Huetos","year":"2017","journal-title":"Hum Reprod Update"},{"key":"key-10.4103\/1008-682X.253097-29","unstructured":"Jungwirth A, Diemer T, Kopa Z, Krausz C, Minhas S, et al. EAU guidelines on male infertility. Available from: http:\/\/www.uroweb.org\/wp-content\/uploads\/EAU-Guidelines-on-Male-Infertility-2018-large-text.pdf. [Last accessed on 2018 Apr 02]."},{"key":"key-10.4103\/1008-682X.253097-30","first-page":"2290\u20137","article-title":"Smoke-related DNA methylation changes in the etiology of human disease","author":"Besingi","year":"2014","journal-title":"Hum Mol Genet"},{"key":"key-10.4103\/1008-682X.253097-31","first-page":"51\u20137","article-title":"Cigarette smoking is associated with abnormal histone-to-protamine transition in human sperm","author":"Yu","year":"2014","journal-title":"Fertil Steril"},{"key":"key-10.4103\/1008-682X.253097-32","first-page":"2708\u201320","article-title":"Protamine contents and P1\/P2 ratio in human spermatozoa from smokers and non-smokers","author":"Hammadeh","year":"2010","journal-title":"Hum Reprod"},{"key":"key-10.4103\/1008-682X.253097-33","first-page":"188\u201396","article-title":"Is smoking a risk factor for decreased semen quality.A cross-sectional analysis?","author":"Ramlau-Hansen","year":"2007","journal-title":"Hum Reprod"},{"key":"key-10.4103\/1008-682X.253097-34","first-page":"409\u201316","article-title":"Formation of reactive oxygen species in spermatozoa of infertile patients","author":"Iwasaki","year":"1992","journal-title":"Fertil Steril"},{"key":"key-10.4103\/1008-682X.253097-35","first-page":"119\u201323","article-title":"Effect of cigarette smoking on semen quality of infertile men","author":"Gaur","year":"2007","journal-title":"Singapore Med J"},{"key":"key-10.4103\/1008-682X.253097-36","first-page":"283\u201392","article-title":"DNA adduct profiles and levels in placenta, blood and lung in relation to cigarette smoking and smoky coal emissions","author":"Gallagher","year":"1993","journal-title":"IARC Sci Publ"},{"key":"key-10.4103\/1008-682X.253097-37","doi-asserted-by":"crossref","unstructured":"Ventimiglia E, Montorsi F, Salonia A. Re: Reecha Sharma, Avi Harlev, Ashok Agarwal, Sandro C. Esteves. Cigarette smoking and semen quality: a new meta-analysis examining the effect of the 2010 World Health Organization laboratory methods for the examination of human semen. Eur Urol 2016; 70: 635\u201345. Erratum in: Eur Urol 2017; 71: e19\u201320.","DOI":"10.1016\/j.eururo.2016.05.051"}],"container-title":["Asian Journal of Andrology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:43:31Z","timestamp":1786715011000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aja.aja_110_18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019]]}},"alternative-id":["253097"],"URL":"https:\/\/doi.org\/10.4103\/aja.aja_110_18","relation":{},"ISSN":["1008-682X"],"issn-type":[{"value":"1008-682X","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]}}}