{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:18:46Z","timestamp":1787847526808,"version":"build-2784847793"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      We analyzed the efficacy of penile low-intensity extracorporeal shockwave treatment for erectile dysfunction (ED) combined with cavernous artery disease (CAD). ED was evaluated by the International Index of Erectile Function, subdividing patients into mild and moderate\/severe forms. CAD was assessed using penile color Doppler ultrasonography. Patients (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 111) with a positive outcome after treatment, based upon the minimal clinically important difference of the International Index of ED, were followed up for 3 months and 6 months. We found a significant mean increase in the index of erectile function, with an overall improvement in hemodynamic parameters of the cavernous artery. In particular, 93.9% of the patients with mild ED without CAD responded to treatment and 72.7% resumed normal erectile function. Only 31.2% of the patients with moderate\/severe ED and CAD responded to treatment, and none resumed normal erectile function. All patients with mild ED and no CAD maintained the effects of therapy after 3 months, while no patients with moderate\/severe ED and CAD maintained the benefits of treatment after 3 months. Thus, patients with mild ED and no CAD have better and longer lasting responses to such treatment, with a higher probability of resuming normal erectile function than patients with moderate\/severe ED and CAD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aja.aja_15_21","type":"journal-article","created":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T05:31:03Z","timestamp":1615872663000},"page":"462-467","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy of penile low-intensity shockwave treatment for erectile dysfunction"],"prefix":"10.4103","volume":"23","author":[{"given":"Nicola","family":"Caretta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"De Rocco Ponce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Minicuci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"De Santis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierfrancesco","family":"Palego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Garolla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Foresta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-4-20240829","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1111\/j.1743-6109.2010.02062.x","article-title":"Summary of the recommendations on sexual dysfunctions in men","volume":"7","author":"Montorsi","year":"2010","journal-title":"J Sex Med"},{"key":"R2-4-20240829","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.eururo.2010.02.020","article-title":"Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation","volume":"57","author":"Hatzimouratidis","year":"2010","journal-title":"Eur Urol"},{"key":"R3-4-20240829","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/S0022-5347(05)67900-1","article-title":"Incidence of erectile dysfunction in men 40 to 69 years old: longitudinal results from the Massachusetts male aging study","volume":"163","author":"Johannes","year":"2000","journal-title":"J Urol"},{"key":"R4-4-20240829","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1056\/NEJM200006153422407","article-title":"Erectile dysfunction","volume":"342","author":"Lue","year":"2000","journal-title":"N Engl J Med"},{"key":"R5-4-20240829","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1006\/pmed.2000.0643","article-title":"Erectile dysfunction and coronary risk factors: prospective results from the Massachusetts male aging study","volume":"30","author":"Feldman","year":"2000","journal-title":"Prev Med"},{"key":"R6-4-20240829","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/sj.ijir.3900622","article-title":"Epidemiology of erectile dysfunction: results of the \u2018Cologne Male Survey\u2019","volume":"12","author":"Braun","year":"2000","journal-title":"Int J Impot Res"},{"key":"R7-4-20240829","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.amjcard.2005.07.006","article-title":"The artery size hypothesis: a macrovascular link between erectile dysfunction and coronary artery disease","volume":"96","author":"Montorsi","year":"2005","journal-title":"Am J Cardiol"},{"key":"R8-4-20240829","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1056\/NEJMoa043814","article-title":"Circulating endothelial progenitor cells and cardiovascular outcomes","volume":"353","author":"Werner","year":"2005","journal-title":"N Engl J Med"},{"key":"R9-4-20240829","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/sj.ijir.3901311","article-title":"Circulating endothelial progenitor cells in subjects with erectile dysfunction","volume":"17","author":"Foresta","year":"2005","journal-title":"Int J Impot Res"},{"key":"R10-4-20240829","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.eururo.2010.04.004","article-title":"Can low intensity extracorporeal shockwave therapy improve erectile function? 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