{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:58:35Z","timestamp":1788393515318,"version":"build-2803163510"},"reference-count":60,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Damage to sperm DNA was proposed to play an important role in embryonic development. Previous studies focused on outcomes after fresh embryo transfer, whereas this study investigated the influence of sperm DNA fragmentation index (DFI) on laboratory and clinical outcomes after frozen embryo transfer (FET). This retrospective study examined 381 couples using cleavage-stage FET. Sperm used for intracytoplasmic sperm injection (ICSI) or\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      fertilization (IVF) underwent density gradient centrifugation and swim up processing. Sperm DFI had a negative correlation with sperm motility (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = \u22120.640,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01), sperm concentration (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = \u22120.289,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01), and fertilization rate of IVF cycles (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = \u22120.247,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01). Sperm DFI examined before and after density gradient centrifugation\/swim up processing was markedly decreased after processing (17.1%\n                      <jats:italic toggle=\"yes\">vs<\/jats:italic>\n                      2.4%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01; 65 randomly picked couples). Sperm progressive motility was significantly reduced in high DFI group compared with low DFI group for both IVF and ICSI (IVF: 46.9% \u00b1 12.4%\n                      <jats:italic toggle=\"yes\">vs<\/jats:italic>\n                      38.5% \u00b1 12.6%, respectively; ICSI: 37.6% \u00b1 14.1%\n                      <jats:italic toggle=\"yes\">vs<\/jats:italic>\n                      22.3% \u00b1 17.8%, respectively; both\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01). The fertilization rate was significantly lower in high (\u226525%) DFI group compared with low (&lt;25%) DFI group using IVF (73.3% \u00b1 23.9%\n                      <jats:italic toggle=\"yes\">vs<\/jats:italic>\n                      53.2% \u00b1 33.6%, respectively;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01) but was equivalent in high and low DFI groups using ICSI. Embryonic development and clinical outcomes after FET were equivalent for low and high DFI groups using ICSI or IVF. In this study, sperm DFI did not provide sufficient information regarding embryo development or clinical outcomes for infertile couples using FET.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aja.aja_17_21","type":"journal-article","created":{"date-parts":[[2021,4,4]],"date-time":"2021-04-04T12:45:44Z","timestamp":1617540344000},"page":"109-115","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":22,"title":["Random sperm DNA fragmentation index is not associated with clinical outcomes in day-3 frozen embryo 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