{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:29:16Z","timestamp":1786739356344,"version":"build-2736575974"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Klinefelter syndrome (KS) is the most common sex chromosome disorder in men. It is characterized by germ cell loss and other variable clinical features, including autoimmunity. The sex-determining region of Y (SRY)-box 13 (\n                      <jats:italic toggle=\"yes\">Sox13<\/jats:italic>\n                      ) gene is expressed in mouse spermatogonia. In addition, it has been identified as islet cell autoantigen 12 (ICA12), which is involved in the pathogenesis of autoimmune diseases, including type 1 diabetes mellitus (DM) and primary biliary cirrhosis.\n                      <jats:italic toggle=\"yes\">Sox13<\/jats:italic>\n                      expression has never been investigated in patients with KS. In this age-matched, case\u2013control study performed on ten patients with KS and ten controls, we found that\n                      <jats:italic toggle=\"yes\">SOX13<\/jats:italic>\n                      is significantly downregulated in peripheral blood mononuclear cells of patients with KS compared to controls. This finding might be consistent with the germ cell loss typical of patients with KS. However, the role of\n                      <jats:italic toggle=\"yes\">SoX13<\/jats:italic>\n                      in the pathogenesis of germ cell loss and humoral autoimmunity in patients with KS deserves to be further explored.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aja.aja_37_20","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T05:35:02Z","timestamp":1603776902000},"page":"157-162","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["SOX13 gene downregulation in peripheral blood mononuclear cells of patients with Klinefelter syndrome"],"prefix":"10.4103","volume":"23","author":[{"given":"Rossella","family":"Cannarella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Salemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosita 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