{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:13:37Z","timestamp":1792642417559,"version":"4.5.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Varicoceles adversely impact semen quality and sperm DNA fragmentation, which typically improve with surgical repair. Some men with varicoceles have ipsilateral testicular atrophy due to damage from the varicocele. This study assessed semen quality and the sperm DNA fragmentation index (DFI) response to varicocele repair in men with ipsilateral testicular atrophy (TA) versus men with no testicular atrophy (NTA). Semen parameter values and DFI in both groups were compared preoperatively and postoperatively. The Mann\u2013Whitney U test and the Wilcoxon signed-rank test were used where appropriate. There were 20 men in the TA group and 121 men in the NTA group with no difference in age, varicocele grade, or preoperative semen parameter values between the two groups. The NTA group had a higher preoperative DFI than the TA group. Both groups showed improvement in semen quality postoperatively, only the TA group showed a significant improvement in DFI, whereas the NTA group showed significant improvements in several parameter values and DFI. The change from preoperative to postoperative parameter values when comparing the two groups revealed a difference in total sperm motile count and DFI, with a larger mean improvement in the NTA group than in the TA group. Both TA and NTA groups showed improved semen quality and DFI after varicocele repair, but the NTA group had more improvement than the TA group. However, only total motile count (TMC) and DFI had a significantly greater mean change in preoperative to postoperative response in the NTA group than in the TA group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aja.aja_50_20","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:49:58Z","timestamp":1600130998000},"page":"146-149","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":10,"title":["The impact of ipsilateral testicular atrophy on semen quality and sperm DNA fragmentation response to varicocele repair"],"prefix":"10.4103","volume":"23","author":[{"given":"Parviz K","family":"Kavoussi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Abdullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa S","family":"Gilkey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Hunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G Luke","family":"Machen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Hung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keikhosrow M","family":"Kavoussi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Esqueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J David","family":"Wininger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahryar K","family":"Kavoussi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-5-20240829","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/oxfordjournals.humrep.a137433","article-title":"Incidence and main causes of infertility in a resident population (1,850,000) of three French regions (1988-1989)","volume":"6","author":"Thonneau","year":"1991","journal-title":"Hum Reprod"},{"key":"R3-5-20240829","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1093\/humrep\/dei429","article-title":"Increased sperm DNA damage in patients with varicocele: relationship with seminal oxidative stress","volume":"21","author":"Smith","year":"2006","journal-title":"Hum Reprod"},{"key":"R4-5-20240829","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.fertnstert.2005.08.032","article-title":"Sperm nuclear DNA fragmentation in adolescents with varicocele","volume":"85","author":"Bertolla","year":"2006","journal-title":"Fertil Steril"},{"key":"R5-5-20240829","doi-asserted-by":"crossref","first-page":"94","DOI":"10.2164\/jandrol.05081","article-title":"Studies on varicocele III: ultrastructural sperm evaluation and 18, X and Y aneuploidies","volume":"27","author":"Baccetti","year":"2006","journal-title":"J Androl"},{"key":"R6-5-20240829","doi-asserted-by":"crossref","first-page":"106","DOI":"10.2164\/jandrol.05115","article-title":"Infertile men with varicocele show a high relative proportion of sperm cells with intense nuclear damage level, evidenced by the sperm chromatin dispersion test","volume":"27","author":"Enciso","year":"2006","journal-title":"J Androl"},{"key":"R7-5-20240829","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1600-0897.2007.00559.x","article-title":"Clinical relevance of oxidative stress in male factor infertility: an update","volume":"59","author":"Agarwal","year":"2008","journal-title":"Am J Reprod Immunol"},{"key":"R8-5-20240829","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1016\/j.fertnstert.2007.09.007","article-title":"Sperm nuclear DNA fragmentation and mitochondrial activity in men with varicocele","volume":"90","author":"Blumer","year":"2008","journal-title":"Fertil Steril"},{"key":"R9-5-20240829","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.fertnstert.2007.12.058","article-title":"Apoptosis-related phenotype of ejaculated spermatozoa in patients with varicocele","volume":"91","author":"Wu","year":"2009","journal-title":"Fertil Steril"},{"key":"R10-5-20240829","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/S0022-5347(17)44053-5","article-title":"Significance of testicular size measurement in andrology: II. 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