{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:42:28Z","timestamp":1786718548578,"version":"build-2736575974"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian J Androl"],"published-print":{"date-parts":[[2018]]},"DOI":"10.4103\/aja.aja_70_17","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T05:39:02Z","timestamp":1517290742000},"page":"115","source":"Crossref","is-referenced-by-count":10,"title":["Endogenous testosterone and mortality risk"],"prefix":"10.4103","volume":"20","author":[{"given":"EmilyJ","family":"Meyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Wittert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/1008-682X.224233-1","first-page":"1460\u20137","volume-title":"Fifteen-year survival outcomes following primary androgen-deprivation therapy for localized prostate cancer","author":"Lu-Yao","year":"2014","journal-title":"JAMA Intern Med"},{"key":"key-10.4103\/1008-682X.224233-2","first-page":"1493\u2013500","volume-title":"Androgen deprivation therapy increases cardiovascular morbidity in men with prostate cancer","author":"Saigal","year":"2007","journal-title":"Cancer"},{"key":"key-10.4103\/1008-682X.224233-3","first-page":"833\u201340","volume-title":"Androgen-deprivation therapy in prostate cancer and cardiovascular risk: a science advisory from the American Heart Association, American Cancer Society, and American Urological Association: endorsed by the American Society for Radiation Oncology","author":"Levine","year":"2010","journal-title":"Circulation"},{"key":"key-10.4103\/1008-682X.224233-4","first-page":"979\u201385","volume-title":"Androgen-suppression therapy for prostate cancer and the risk of death in men with a history of myocardial infarction or stroke","author":"Hayes","year":"2010","journal-title":"BJU Int"},{"key":"key-10.4103\/1008-682X.224233-5","first-page":"415\u201321","volume-title":"Identification of comorbidities that place men at highest risk of death from androgen deprivation therapy before brachytherapy for prostate cancer","author":"Parekh","year":"2013","journal-title":"Brachytherapy"},{"key":"key-10.4103\/1008-682X.224233-6","first-page":"3289\u201397","volume-title":"Longitudinal changes in testosterone over five years in community-dwelling men","author":"Shi","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/1008-682X.224233-7","first-page":"445\u201355","volume-title":"Age-associated changes in hypothalamic-pituitary-testicular function in middle-aged and older men are modified by weight change and lifestyle factors: longitudinal results from the European Male Ageing Study","author":"Camacho","year":"2013","journal-title":"Eur J Endocrinol"},{"key":"key-10.4103\/1008-682X.224233-8","first-page":"42\u20139","volume-title":"Factors impacting all-cause mortality in prostate cancer brachytherapy patients with or without androgen deprivation therapy","author":"Taira","year":"2010","journal-title":"Brachytherapy"},{"key":"key-10.4103\/1008-682X.224233-9","first-page":"605\u201313","volume-title":"Endothelial dysfunction, insulin resistance and inflammation in congenital hypogonadism, and the effect of testosterone replacement","author":"Sonmez","year":"2015","journal-title":"Endocr J"},{"key":"key-10.4103\/1008-682X.224233-10","first-page":"640\u20134","volume-title":"Evaluation of adipocytokine levels and vascular functions in young aged to middle aged men with idiopathic hypogonadotrophic hypogonadism","author":"Tuna","year":"2014","journal-title":"Neuro Endocrinol Lett"},{"key":"key-10.4103\/1008-682X.224233-11","unstructured":"Mao JF, Wu XY, Li NS, Lu SY, Jing ZM, et al. [Testosterone replacement in hypogonadotropic hypogonadal young male improves insulin sensitivity]. Zhonghua Yi Xue Za Zhi 2008; 88: 2550\u20132. [Article in Chinese]."},{"key":"key-10.4103\/1008-682X.224233-12","first-page":"215","volume-title":"Lifespan and testosterone","author":"Nieschlag","year":"1993","journal-title":"Nature"},{"key":"key-10.4103\/1008-682X.224233-13","first-page":"4254\u20139","volume-title":"Acute sex steroid withdrawal reduces insulin sensitivity in healthy men with idiopathic hypogonadotropic hypogonadism","author":"Yialamas","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/1008-682X.224233-14","first-page":"622\u20136","volume-title":"Prenatal and postnatal prevalence of Klinefelter syndrome: a national registry study","author":"Bojesen","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/1008-682X.224233-15","first-page":"3830\u20134","volume-title":"Increased mortality in Klinefelter syndrome","author":"Bojesen","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/1008-682X.224233-16","first-page":"33\u20138","volume-title":"Mortality ratios and life expectancy in X chromatin positive males","author":"Price","year":"1985","journal-title":"J Epidemiol Community Health"},{"key":"key-10.4103\/1008-682X.224233-17","first-page":"177\u201388","volume-title":"Mortality and cancer incidence in persons with numerical sex chromosome abnormalities: a cohort study","author":"Swerdlow","year":"2001","journal-title":"Ann Hum Genet"},{"key":"key-10.4103\/1008-682X.224233-18","first-page":"1204\u201310","volume-title":"Cancer incidence and mortality in men with Klinefelter syndrome: a cohort study","author":"Swerdlow","year":"2005","journal-title":"J Natl Cancer Inst"},{"key":"key-10.4103\/1008-682X.224233-19","first-page":"416\u201320","volume-title":"Cancer incidence in men with Klinefelter syndrome","author":"Hasle","year":"1995","journal-title":"Br J Cancer"},{"key":"key-10.4103\/1008-682X.224233-20","first-page":"R27\u201340","volume-title":"Klinefelter syndrome, cardiovascular system, and thromboembolic disease: review of literature and clinical perspectives","author":"Salzano","year":"2016","journal-title":"Eur J Endocrinol"},{"key":"key-10.4103\/1008-682X.224233-21","first-page":"754\u20139","volume-title":"Cardiovascular abnormalities in Klinefelter syndrome","author":"Pasquali","year":"2013","journal-title":"Int J Cardiol"},{"key":"key-10.4103\/1008-682X.224233-22","first-page":"e642\u20138","volume-title":"Genotype and phenotype in Klinefelter syndrome \u2013 Impact of androgen receptor polymorphism and skewed X inactivation","author":"Bojesen","year":"2011","journal-title":"Int J Androl"},{"key":"key-10.4103\/1008-682X.224233-23","first-page":"20150113","volume-title":"The importance of having two X chromosomes","author":"Arnold","year":"2016","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"key-10.4103\/1008-682X.224233-24","first-page":"777\u201386","volume-title":"Testosterone, dihydrotestosterone and estradiol are differentially associated with carotid intima-media thickness and the presence of carotid plaque in men with and without coronary artery disease","author":"Chan","year":"2015","journal-title":"Endocr J"},{"key":"key-10.4103\/1008-682X.224233-25","first-page":"4565\u201373","volume-title":"In older men, higher plasma testosterone or dihydrotestosterone is an independent predictor for reduced incidence of stroke but not myocardial infarction","author":"Yeap","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/1008-682X.224233-26","first-page":"E9\u201318","volume-title":"In older men an optimal plasma testosterone is associated with reduced all-cause mortality and higher dihydrotestosterone with reduced ischemic heart disease mortality, while estradiol levels do not predict mortality","author":"Yeap","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/1008-682X.224233-27","first-page":"3007\u201319","volume-title":"Clinical review: endogenous testosterone and mortality in men: a systematic review and meta-analysis","author":"Araujo","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/1008-682X.224233-28","first-page":"1357\u201366","volume-title":"Late-onset hypogonadism and mortality in aging men","author":"Pye","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/1008-682X.224233-29","first-page":"2061\u20138","volume-title":", et al. Testosterone, dihydrotestosterone, and incident cardiovascular disease and mortality in the cardiovascular health study","author":"Shores","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/1008-682X.224233-30","first-page":"4472\u201380","volume-title":"The association of reproductive hormone levels and all-cause, cancer, and cardiovascular disease mortality in men","author":"Holmboe","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/1008-682X.224233-31","first-page":"2201\u201310","volume-title":"Temporal changes in androgens and estrogens are associated with all-cause and cause-specific mortality in older men","author":"Hsu","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/1008-682X.224233-32","first-page":"444\u201352","volume-title":"Prevalence and prognosis of a low serum testosterone in men with type 2 diabetes: the Fremantle Diabetes Study Phase II","author":"Hamilton","year":"2016","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key-10.4103\/1008-682X.224233-33","first-page":"725\u201333","volume-title":"Testosterone deficiency is associated with increased risk of mortality and testosterone replacement improves survival in men with type 2 diabetes","author":"Muraleedharan","year":"2013","journal-title":"Eur J Endocrinol"},{"key":"key-10.4103\/1008-682X.224233-34","first-page":"97\u2013105","volume-title":"Low testosterone and clinical outcomes in Chinese men with type 2 diabetes mellitus \u2013 Hong Kong Diabetes Registry","author":"Cheung","year":"2017","journal-title":"Diabetes Res Clin Pract"},{"key":"key-10.4103\/1008-682X.224233-35","first-page":"5054\u201360","volume-title":"Testosterone levels and quality of life in diverse male patients with cancers unrelated to androgens","author":"Fleishman","year":"2010","journal-title":"J Clin Oncol"},{"key":"key-10.4103\/1008-682X.224233-36","first-page":"851\u20138","volume-title":"Symptomatic hypogonadism in male survivors of cancer with chronic exposure to opioids","author":"Rajagopal","year":"2004","journal-title":"Cancer"},{"key":"key-10.4103\/1008-682X.224233-37","first-page":"2583\u201391","volume-title":"Hypogonadism in male patients with cancer","author":"Garcia","year":"2006","journal-title":"Cancer"},{"key":"key-10.4103\/1008-682X.224233-38","first-page":"15\u201323","volume-title":"Presence of delta opioid receptors on a subset of hypothalamic gonadotropin releasing hormone (GnRH) neurons","author":"Pimpinelli","year":"2006","journal-title":"Brain Res"},{"key":"key-10.4103\/1008-682X.224233-39","first-page":"545\u20137","volume-title":"Plasma testosterone and luteinizing hormone levels during levo-alpha-acetylmethadol maintenance and withdrawal","author":"Mendelson","year":"1984","journal-title":"Clin Pharmacol Ther"},{"key":"key-10.4103\/1008-682X.224233-40","first-page":"1494\u2013501","volume-title":"Low serum testosterone levels are associated with increased risk of mortality in a population-based cohort of men aged 20-79","author":"Haring","year":"2010","journal-title":"Eur Heart J"},{"key":"key-10.4103\/1008-682X.224233-41","first-page":"2694\u2013701","volume-title":"Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men: European prospective investigation into cancer in Norfolk (EPIC-Norfolk) Prospective Population Study","author":"Khaw","year":"2007","journal-title":"Circulation"},{"key":"key-10.4103\/1008-682X.224233-42","first-page":"68\u201375","volume-title":"Low serum testosterone and mortality in older men","author":"Laughlin","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/1008-682X.224233-43","first-page":"1252\u201360","volume-title":"Sex steroids and all-cause and cause-specific mortality in men","author":"Araujo","year":"2007","journal-title":"Arch Intern Med"},{"key":"key-10.4103\/1008-682X.224233-44","first-page":"1254\u201360","volume-title":"Morbidity in Klinefelter syndrome: a Danish register study based on hospital discharge diagnoses","author":"Bojesen","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/1008-682X.224233-45","first-page":"145\u201361","volume-title":"Hypothalamo-pituitary gonadal axis in chronic renal failure","author":"Handelsman","year":"1993","journal-title":"Endocrinol Metab Clin North Am"},{"key":"key-10.4103\/1008-682X.224233-46","first-page":"4030\u201341","volume-title":"The vulnerable man: impact of testosterone deficiency on the uraemic phenotype","author":"Carrero","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"key-10.4103\/1008-682X.224233-47","first-page":"209\u201317","volume-title":"Low serum testosterone is associated with increased mortality in men with stage 3 or greater nephropathy","author":"Haring","year":"2011","journal-title":"Am J Nephrol"},{"key":"key-10.4103\/1008-682X.224233-48","first-page":"767\u201375","volume-title":"Sex steroids levels in chronic kidney disease and kidney transplant recipients: associations with disease severity and prediction of mortality","author":"Grossmann","year":"2015","journal-title":"Clin Endocrinol"},{"key":"key-10.4103\/1008-682X.224233-49","first-page":"870\u20135","volume-title":"Endogenous testosterone and cardiovascular disease in healthy men: a meta-analysis","author":"Ruige","year":"2011","journal-title":"Heart"},{"key":"key-10.4103\/1008-682X.224233-50","first-page":"2341\u201353","volume-title":"Low testosterone in men with type 2 diabetes: significance and treatment","author":"Grossmann","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/1008-682X.224233-51","first-page":"828\u201332","volume-title":"The effect of weight loss on reproductive hormones in obese men","author":"Stanik","year":"1981","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/1008-682X.224233-52","first-page":"1396\u2013403","volume-title":"Effects of a low-energy diet on sexual function and lower urinary tract symptoms in obese men","author":"Khoo","year":"2010","journal-title":"Int J Obes (Lond)"},{"key":"key-10.4103\/1008-682X.224233-53","first-page":"3277\u201384","volume-title":"Plasma adrenal, gonadal, and conjugated steroids before and after long-term overfeeding in identical twins","author":"Pritchard","year":"1998","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Asian Journal of Andrology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:36:22Z","timestamp":1786714582000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aja.aja_70_17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018]]}},"alternative-id":["224233"],"URL":"https:\/\/doi.org\/10.4103\/aja.aja_70_17","relation":{},"ISSN":["1008-682X"],"issn-type":[{"value":"1008-682X","type":"print"}],"subject":[],"published":{"date-parts":[[2018]]}}}