{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:52:56Z","timestamp":1786719176012,"version":"build-2736575974"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian J Androl"],"published-print":{"date-parts":[[2019]]},"DOI":"10.4103\/aja.aja_8_19","type":"journal-article","created":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T06:22:54Z","timestamp":1552630974000},"page":"452","source":"Crossref","is-referenced-by-count":15,"title":["Losartan improves erectile function through suppression of corporal apoptosis and oxidative stress in rats with cavernous nerve injury"],"prefix":"10.4103","volume":"21","author":[{"given":"Ning-Hong","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Hu","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Jian","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/1008-682X.254314-1","first-page":"153\u201365","article-title":"Erectile dysfunction","author":"Shamloul","year":"2013","journal-title":"Lancet"},{"key":"key-10.4103\/1008-682X.254314-2","first-page":"50\u20136","article-title":"The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences","author":"Ayta","year":"1999","journal-title":"BJU Int"},{"key":"key-10.4103\/1008-682X.254314-3","doi-asserted-by":"crossref","first-page":"e0174145","DOI":"10.1371\/journal.pone.0174145","article-title":"Combination of mesenchymal stem cell injection with icariin for the treatment of diabetes-associated erectile dysfunction","author":"Wang","year":"2017","journal-title":"PLoS One"},{"key":"key-10.4103\/1008-682X.254314-4","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0302-2838(02)00219-1","article-title":"Patient-reported sexual function after nerve-sparing radical retropubic prostatectomy","author":"Noldus","year":"2002","journal-title":"Eur Urol"},{"key":"key-10.4103\/1008-682X.254314-5","first-page":"597\u2013601","article-title":"Erectile function outcome reporting after clinically localized prostate cancer treatment","author":"Burnett","year":"2007","journal-title":"J Urol"},{"key":"key-10.4103\/1008-682X.254314-6","first-page":"998\u20131008","article-title":"Penile rehabilitation after radical prostatectomy: what the evidence really says","author":"Fode","year":"2013","journal-title":"BJU Int"},{"key":"key-10.4103\/1008-682X.254314-7","first-page":"289\u201397","article-title":"Landmarks in erectile function recovery after radical prostatectomy","author":"Weyne","year":"2015","journal-title":"Nat Rev Urol"},{"key":"key-10.4103\/1008-682X.254314-8","first-page":"111\u20136","article-title":"Fibrosis of corpus cavernosum in animals following cavernous nerve ablation","author":"Hu","year":"2004","journal-title":"Asian J Androl"},{"key":"key-10.4103\/1008-682X.254314-9","first-page":"239\u201345","article-title":"Cavernous neurotomy causes hypoxia and fibrosis in rat corpus cavernosum","author":"Leungwattanakij","year":"2003","journal-title":"J Androl"},{"key":"key-10.4103\/1008-682X.254314-10","first-page":"626\u201330","article-title":"Apoptosis in the rat penis after penile denervation","author":"Klein","year":"1997","journal-title":"J Urol"},{"key":"key-10.4103\/1008-682X.254314-11","first-page":"908\u201316","article-title":"FK506 and sildenafil promote erectile function recovery after cavernous nerve injury through antioxidative mechanisms","author":"Lagoda","year":"2007","journal-title":"J Sex Med"},{"key":"key-10.4103\/1008-682X.254314-12","first-page":"419\u201331","article-title":"Effect of chronic tadalafil administration on penile hypoxia induced by cavernous neurotomy in the rat","author":"Vignozzi","year":"2006","journal-title":"J Sex Med"},{"key":"key-10.4103\/1008-682X.254314-13","first-page":"424\u20138","article-title":"Expression of transforming growth factor-beta1 in penile tissue from rats with bilateral cavernosal nerve ablation","author":"Hu","year":"2004","journal-title":"BJU Int"},{"key":"key-10.4103\/1008-682X.254314-14","first-page":"183\u201391","article-title":"The angiotensin II receptor blockers: opportunities across the spectrum of cardiovascular disease","author":"Weber","year":"2002","journal-title":"Rev Cardiovasc Med"},{"key":"key-10.4103\/1008-682X.254314-15","first-page":"493\u20138","article-title":"Tissue angiotensin system in cardiovascular medicine.A paradigm shift?","author":"Dzau","year":"1994","journal-title":"Circulation"},{"key":"key-10.4103\/1008-682X.254314-16","doi-asserted-by":"crossref","unstructured":"Kifor I, Williams GH, Vickers MA, Sullivan MP, Jodbert P, et al. Tissue angiotensin II as a modulator of erectile function. I. Angiotensin peptide content, secretion and effects in the corpus cavernosum. J Urol 1997; 157: 1920\u20135.","DOI":"10.1016\/S0022-5347(01)64901-2"},{"key":"key-10.4103\/1008-682X.254314-17","first-page":"333\u201345","article-title":"Losartan preserves erectile function by suppression of apoptosis and fibrosis of corpus cavernosum and corporal veno-occlusive dysfunction in diabetic rats","author":"Li","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"key-10.4103\/1008-682X.254314-18","first-page":"419\u201327","article-title":"Angiotensin II silencing alleviates erectile dysfunction through down-regulating the Rhoa\/Rho kinase signaling pathway in rats with diabetes mellitus","author":"Zhang","year":"2018","journal-title":"Cell Physiol Biochem"},{"key":"key-10.4103\/1008-682X.254314-19","first-page":"495\u2013500","article-title":"Immunophilin ligands promote penile neurogenesis and erection recovery after cavernous nerve injury","author":"Burnett","year":"2004","journal-title":"J Urol"},{"key":"key-10.4103\/1008-682X.254314-20","first-page":"778\u201385","article-title":"Taurine supplementation improves erectile function in rats with streptozotocin-induced type 1 diabetes via amelioration of penile fibrosis and endothelial dysfunction","author":"Ruan","year":"2016","journal-title":"J Sex Med"},{"key":"key-10.4103\/1008-682X.254314-21","first-page":"1072\u201382","article-title":"PARP inhibition restores erectile function by suppressing corporal smooth muscle apoptosis in diabetic rats","author":"Li","year":"2011","journal-title":"J Sex Med"},{"key":"key-10.4103\/1008-682X.254314-22","first-page":"466\u201371","article-title":"Phosphodiesterase type 5 inhibitors for the treatment of erectile dysfunction in patients with diabetes mellitus","author":"Vickers","year":"2002","journal-title":"Int J Impot Res"},{"key":"key-10.4103\/1008-682X.254314-23","first-page":"2942\u201351","article-title":"P144, a TGF-beta1 antagonist peptide, synergizes with sildenafil and enhances erectile response via amelioration of cavernosal fibrosis in diabetic rats","author":"Li","year":"2013","journal-title":"J Sex Med"},{"key":"key-10.4103\/1008-682X.254314-24","doi-asserted-by":"crossref","first-page":"e0186077","DOI":"10.1371\/journal.pone.0186077","article-title":"The effect of cavernous nerve traction on erectile function in rats","author":"Li","year":"2017","journal-title":"PLoS One"},{"key":"key-10.4103\/1008-682X.254314-25","first-page":"1716\u201323","article-title":"Restoration of erectile function by suppression of corporal apoptosis, fibrosis and corporal veno-occlusive dysfunction with rho-kinase inhibitors in a rat model of cavernous nerve injury","author":"Cho","year":"2015","journal-title":"J Urol"},{"key":"key-10.4103\/1008-682X.254314-26","first-page":"5","article-title":"Neurturin enhances the recovery of erectile function following bilateral cavernous nerve crush injury in the rat","author":"Bella","year":"2007","journal-title":"J Brachial Plex Peripher Nerve Inj"},{"key":"key-10.4103\/1008-682X.254314-27","first-page":"2103\u20139","article-title":"The effect of adeno-associated virus mediated brain derived neurotrophic factor in an animal model of neurogenic impotence","author":"Bakircioglu","year":"2001","journal-title":"J Urol"},{"key":"key-10.4103\/1008-682X.254314-28","first-page":"824\u20139","article-title":"The effect of FK1706 on erectile function following bilateral cavernous nerve crush injury in a rat model","author":"Hayashi","year":"2006","journal-title":"J Urol"},{"key":"key-10.4103\/1008-682X.254314-29","first-page":"341\u20136","article-title":"FK1706 enhances the recovery of erectile function following bilateral cavernous nerve crush injury in the rat","author":"Bella","year":"2007","journal-title":"J Sex Med"},{"key":"key-10.4103\/1008-682X.254314-30","first-page":"3351\u201364","article-title":"A mouse model of cavernous nerve injury-induced erectile dysfunction: functional and morphological characterization of the corpus cavernosum","author":"Jin","year":"2010","journal-title":"J Sex Med"},{"key":"key-10.4103\/1008-682X.254314-31","first-page":"2816\u201322","article-title":"Losartan preserves erectile function after bilateral cavernous nerve injury via antifibrotic mechanisms in male rats","author":"Canguven","year":"2009","journal-title":"J Urol"},{"key":"key-10.4103\/1008-682X.254314-32","first-page":"696\u2013707","article-title":"Losartan, an angiotensin type I receptor, restores erectile function by downregulation of cavernous renin-angiotensin system in streptozocin-induced diabetic rats","author":"Yang","year":"2009","journal-title":"J Sex Med"},{"key":"key-10.4103\/1008-682X.254314-33","first-page":"217\u201320","article-title":"Losartan improves erectile dysfunction in diabetic patients: a clinical trial","author":"Chen","year":"2012","journal-title":"Int J Impot Res"},{"key":"key-10.4103\/1008-682X.254314-34","first-page":"123\u20138","article-title":"Restoration of erectile capacity in normotensive aged rats by modulation of angiotensin receptor type 1","author":"Park","year":"2005","journal-title":"J Androl"},{"key":"key-10.4103\/1008-682X.254314-35","first-page":"1291\u2013303","article-title":"Functional and morphological improvement in erectile tissue of hypertensive rats by long-term combined therapy with phosphodiesterase type 5 inhibitor and losartan","author":"Toblli","year":"2007","journal-title":"J Sex Med"},{"key":"key-10.4103\/1008-682X.254314-36","first-page":"372\u20138","article-title":"Role of inhibiting LIM-kinase2 in improving erectile function through suppression of corporal fibrosis in a rat model of cavernous nerve injury","author":"Park","year":"2018","journal-title":"Asian J Androl"},{"key":"key-10.4103\/1008-682X.254314-37","first-page":"166\u201372","article-title":"Lipoxin A4 improves erectile dysfunction in rats with type I diabetes by inhibiting oxidative stress and corporal fibrosis","author":"Cui","year":"2018","journal-title":"Asian J Androl"},{"key":"key-10.4103\/1008-682X.254314-38","first-page":"960\u201371","article-title":"Superoxide anion production by NADPH oxidase plays a major role in erectile dysfunction in middle-aged rats: prevention by antioxidant therapy","author":"Silva","year":"2013","journal-title":"J Sex Med"},{"key":"key-10.4103\/1008-682X.254314-39","first-page":"958\u201365","article-title":"The changes of microRNA expression in the corpus cavernosum of a rat model with cavernous nerve injury","author":"Liu","year":"2018","journal-title":"J Sex Med"}],"container-title":["Asian Journal of Andrology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:44:53Z","timestamp":1786715093000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aja.aja_8_19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019]]}},"alternative-id":["254314"],"URL":"https:\/\/doi.org\/10.4103\/aja.aja_8_19","relation":{},"ISSN":["1008-682X"],"issn-type":[{"value":"1008-682X","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]}}}