{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T17:45:07Z","timestamp":1791999907531,"version":"4.4.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:p>\n                    During recent decades, the association between mutations in ubiquitin-specific protease 26 (\n                    <jats:italic toggle=\"yes\">USP26<\/jats:italic>\n                    ) and male infertility remains doubtful. We conducted this meta-analysis to evaluate the association between mutations in\n                    <jats:italic toggle=\"yes\">USP26<\/jats:italic>\n                    and male infertility according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. It was registered in the International Prospective Register of Systematic Reviews (PROSPERO; CRD42021225251). PubMed, Web of Science, and Scopus were systematically searched for comparative clinical studies, which were written in English and provided eligible data. Studies were included when they compared\n                    <jats:italic toggle=\"yes\">USP26<\/jats:italic>\n                    mutations in azoospermic, oligozoospermic, and asthenozoospermic patients with controls with normal sperm parameter values or whose partners had experienced spontaneous pregnancy. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated with random effect models. Overall, twelve studies with 3927 infertility patients and 4648 healthy controls were included. The association between overall\n                    <jats:italic toggle=\"yes\">USP26<\/jats:italic>\n                    mutations and infertility was not significant (OR = 1.60, 95% CI: 0.51\u20135.01). For specific mutations, the pooled ORs were 1.65 (95% CI: 1.02\u20132.69) for cluster mutation (including 370\u2013371insACA, 494T&gt;C, and 1423C&gt;T), 1.80 (95% CI: 0.35\u20139.15) for c.576G&gt;A, 1.43 (95% CI: 0.79\u20132.56) for c.1090C&gt;T, and 3.59 (95% CI: 2.30\u20135.59) for c.1737G&gt;A. Our results suggest that several mutations (cluster mutation, c.1737G&gt;A) may play roles in male infertility, while others (c.576G&gt;A and c.1090C&gt;T) do not show notable associations with male infertility. More high-quality clinical researches are needed for validation.\n                  <\/jats:p>","DOI":"10.4103\/aja2021109","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T09:59:00Z","timestamp":1642759140000},"page":"422-429","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["The association between mutations in ubiquitin-specific protease 26 (USP26) and male infertility: a systematic review and meta-analysis"],"prefix":"10.4103","volume":"24","author":[{"given":"Qin-Yu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Cong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Geriatric, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Da","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-Liang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Cheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Urology, Tongji Hospital, Tongji 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