{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:37:05Z","timestamp":1786739825558,"version":"build-2736575974"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      This study explored the usefulness of two-dimensional shear wave elastography (2D-SWE) in the early assessment of corpora cavernosa fibrosis (CCF). New Zealand male rabbits were randomly assigned to an experimental group or a control group. Recombinant human transforming growth factor beta 1 (TGF-\u03b21) was injected into the dorsal penis tissue of rabbits in the experimental group. Conventional ultrasound and 2D-SWE examinations were performed before and 20 days after injection. Penile histological analysis was performed by hematoxylin\u2013eosin staining, sirius red staining, and immunohistochemistry. Measurement of 2D-SWE examination results was performed using shear wave elastography quantitative measurement (SWQ). Histological analysis outcomes were the proportion of smooth muscle cells (SMCs), collagen fibers (CFs), collagen type I (Col I), and collagen type III (Col III), as well as the SMCs\/CFs ratio, measured by sirius red staining. Other histological analysis outcomes were the positive area proportion (PAP) of TGF-\u03b21 (PAP\n                      <jats:sub>T<\/jats:sub>\n                      ), fibronectin (PAP\n                      <jats:sub>F<\/jats:sub>\n                      ), and Col III (PAP\n                      <jats:sub>C<\/jats:sub>\n                      ), measured by immunohistochemistry. After recombinant human TGF-\u03b21 injection, SWQ was higher in the experimental group than that in the control group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001); however, there were no differences in conventional ultrasound results. There were significant differences in histological outcomes between the two groups (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). These results indicated that 2D-SWE was superior for identifying early histological changes in CCF.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aja202147","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T13:24:55Z","timestamp":1630934695000},"page":"207-212","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Experimental investigation of early assessment of corpora cavernosa fibrosis with two-dimensional shear wave elastography"],"prefix":"10.4103","volume":"24","author":[{"given":"Li","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Ting","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Dong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Fang","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-16-20240829","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.urology.2018.12.019","article-title":"New perspectives into Peyronie's disease: etiology, management, and prevention","volume":"125","author":"Montague","year":"2019","journal-title":"Urology"},{"key":"R2-16-20240829","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s11930-015-0045-y","article-title":"Peyronie's disease: a review of etiology, diagnosis, and management","volume":"7","author":"Bilgutay","year":"2015","journal-title":"Curr Sex Health Rep"},{"key":"R3-16-20240829","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00345-004-0424-x","article-title":"Ultrasound in patients affected with Peyronie's disease","volume":"22","author":"Fornara","year":"2004","journal-title":"World J Urol"},{"key":"R4-16-20240829","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.juro.2015.05.098","article-title":"Peyronie's disease: AUA guideline","volume":"194","author":"Nehra","year":"2015","journal-title":"J Urol"},{"key":"R5-16-20240829","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.urology.2018.01.040","article-title":"A novel non-invasive ultrasound vibro-elastography technique for assessing patients with erectile dysfunction and Peyronie's disease","volume":"116","author":"Zhang","year":"2018","journal-title":"Urology"},{"key":"R6-16-20240829","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.ultrasmedbio.2015.03.009","article-title":"WFUMB guidelines and recommendations for clinical use of ultrasound elastography: part 1: basic principles and terminology","volume":"41","author":"Shiina","year":"2015","journal-title":"Ultrasound Med Biol"},{"key":"R7-16-20240829","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1016\/j.ultrasmedbio.2018.07.031","article-title":"Point shear wave elastography for non-invasive assessment of liver fibrosis in patients with viral hepatitis","volume":"44","author":"Bucsics","year":"2018","journal-title":"Ultrasound Med Biol"},{"key":"R8-16-20240829","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1743-6109.2008.01104.x","article-title":"Experimental models of Peyronie's disease. 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