{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:28:12Z","timestamp":1790645292059,"version":"4.1.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      This study aims to compare the prevalence of sexually transmitted infections (STIs) with semen quality in men from couples with primary and secondary infertility. Semen samples were collected from 133 men who requested fertility evaluation. Seminal tract infection with\n                      <jats:italic toggle=\"yes\">Ureaplasma<\/jats:italic>\n                      spp. (UU),\n                      <jats:italic toggle=\"yes\">Mycoplasma hominis<\/jats:italic>\n                      (MH),\n                      <jats:italic toggle=\"yes\">Mycoplasma genitalium<\/jats:italic>\n                      (MG),\n                      <jats:italic toggle=\"yes\">Chlamydia trachomatis<\/jats:italic>\n                      (CT),\n                      <jats:italic toggle=\"yes\">Neisseria gonorrhoeae<\/jats:italic>\n                      (NG), and herpes simplex virus-2 (HSV-2) was assessed by PCR-based diagnostic assays. Among all patients, the prevalence of STIs was higher in men from couples with primary infertility than that in men from couples with secondary infertility (39.7%\n                      <jats:italic toggle=\"yes\">vs<\/jats:italic>\n                      21.7%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03). The prevalence of UU was 28.8% and 13.3% in men from couples with primary and secondary infertility, respectively. Men from couples with primary infertility were more likely to be positive for UU than men from couples with secondary infertility (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04). Regarding the UU subtype, the prevalence of\n                      <jats:italic toggle=\"yes\">Ureaplasma urealyticum<\/jats:italic>\n                      (Uuu) and\n                      <jats:italic toggle=\"yes\">Ureaplasma parvum<\/jats:italic>\n                      (Uup; including Uup1, Uup3, Uup6, and Uup14) did not differ between the two groups. No associations between the prevalence rates of MH, MG, and CT were found in men from either infertility group. A lower sperm concentration was associated with STI pathogen positivity in men with primary infertility according to the crude model (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04). The crude and adjusted models showed that semen volume (both\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03) and semen leukocyte count (both\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02) were independently associated with secondary infertility. These findings suggest the importance of classifying the type of infertility during routine diagnosis of seminal tract infections.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aja202164","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T08:20:41Z","timestamp":1632212441000},"page":"317-322","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":18,"title":["Association of sexually transmitted infection with semen quality in men from couples with primary and secondary infertility"],"prefix":"10.4103","volume":"24","author":[{"given":"Shun","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Hong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jun","family":"Shui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Han","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Xun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-Ling","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Na","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Qiang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Hong","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Chun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-16-20240829","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.fertnstert.2018.08.015","article-title":"Male 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