{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:19:51Z","timestamp":1791976791836,"version":"4.4.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:p>\n                    The historical dogma that bladder calculi comprise the main indication for prostatic surgery has recently been questioned. In this study, we aimed to predict which patients should undergo simultaneous prostate and bladder calculi surgery or only bladder calculi removal by evaluating preoperative risk factors. One hundred and seventeen men with bladder stones and concomitant benign prostate enlargement (BPE) who had not received medical treatment before were included in the study. In the first step, only the bladder calculi of patients were removed and medical treatment was given for BPE. The patients who benefited from medical treatment during the follow-up were defined as Group 1 and the patients who required prostate surgery for any indication comprised Group 2. Risk factors for prostate surgery requirements were determined by comparing preoperative characteristics between the two groups with a cox regression model. In the follow-up of 117 patients with bladder stones removed and medical treatment initiated, 49 (41.9%) patients had prostate surgery indications. The indication for 33 (67.3%) of 49 patients was medical treatment failure. The presence of intravesical prostatic protrusion (IPP; hazard ratio: 2.071, 95% confidence interval [CI]: 1.05\u20134.05,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.034), and high postvoiding residual urine volume (hazard ratio: 1.013, 95% CI: 1.007\u20131.019,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001) were found to be preoperative risk factors for needing future prostate surgery. In patients who have not received medical treatment for BPE before, bladder calculi developing secondary to BPE do not always constitute an indication for prostate surgery.\n                  <\/jats:p>","DOI":"10.4103\/aja2022107","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T11:39:23Z","timestamp":1674646763000},"page":"604-607","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Bladder calculi concomitant with benign prostatic enlargement: is prostate surgery mandatory in patients who have never received medical therapy?"],"prefix":"10.4103","volume":"25","author":[{"given":"Hakan","family":"Anil","sequence":"first","affiliation":[{"name":"Department of Urology, Adana City Training and Research Hospital, Adana 01000, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umut","family":"\u00dcnal","sequence":"additional","affiliation":[{"name":"Department of Urology, Adana City Training and Research Hospital, Adana 01000, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaan","family":"Karamik","sequence":"additional","affiliation":[{"name":"Department of Urology, Korkuteli State Hospital, Antalya 07000, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferhat","family":"Ortoglu","sequence":"additional","affiliation":[{"name":"Department of Urology, Adana City Training and Research Hospital, Adana 01000, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Er\u00e7il","sequence":"additional","affiliation":[{"name":"Department of Urology, Adana City Training and Research Hospital, Adana 01000, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,1,27]]},"reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0094-0143(05)70262-7","article-title":"The vesical calculus","volume":"27","author":"Schwartz","year":"2000","journal-title":"Urol Clin North Am"},{"key":"R2-20240829","first-page":"S45","article-title":"Epidemiology of nephrolithiasis","volume":"13","author":"Ramello","year":"2000","journal-title":"J Nephrol"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/0090-4295(91)80293-G","article-title":"Predisposing factors in bladder calculi. Review of 100 cases","volume":"37","author":"Douenias","year":"1991","journal-title":"Urology"},{"key":"R4-20240829","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.eururo.2005.08.015","article-title":"Holmium laser enucleation of the prostate (HoLEP): the endourologic alternative to open prostatectomy","volume":"49","author":"Elzayat","year":"2006","journal-title":"Eur Urol"},{"key":"R5-20240829","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.juro.2009.11.034","article-title":"Experience with more than 1,000 holmium laser prostate enucleations for benign prostatic hyperplasia","volume":"183","author":"Krambeck","year":"2010","journal-title":"J Urol"},{"key":"R6-20240829","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1056\/NEJMoa030656","article-title":"The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia","volume":"349","author":"McConnell","year":"2003","journal-title":"N Engl J Med"},{"key":"R7-20240829","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.eururo.2014.12.038","article-title":"EAU Guidelines on the assessment of non-neurogenic male lower urinary tract symptoms including benign prostate enlargement","volume":"67","author":"Gratzke","year":"2015","journal-title":"Eur Urol"},{"key":"R8-20240829","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1590\/S1677-55382008000500012","article-title":"Intravesical protrusion of the prostate as a predictive method of bladder outlet obstruction","volume":"34","author":"Reis","year":"2008","journal-title":"Int Braz J Urol"},{"key":"R9-20240829","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1046\/j.1464-410X.2003.04088.x","article-title":"Correlation of intravesical prostatic protrusion with bladder outlet obstruction","volume":"91","author":"Chia","year":"2003","journal-title":"BJU Int"},{"key":"R10-20240829","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0022-5347(01)62081-0","article-title":"Distribution of post-void residual urine volume in randomly selected men","volume":"161","author":"Kolman","year":"1999","journal-title":"J Urol"},{"key":"R11-20240829","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.urology.2010.10.035","article-title":"Prospective comparative study of endoscopic management of bladder lithiasis: is prostate surgery a necessary adjunct?","volume":"78","author":"Philippou","year":"2011","journal-title":"Urology"},{"key":"R12-20240829","first-page":"85","article-title":"Vesical stone: the clinical features of 652 cases","volume":"68","author":"Smith","year":"1975","journal-title":"Irish Med J"},{"key":"R13-20240829","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/j.1464-410X.2006.06570.x","article-title":"Simultaneous transurethral cystolithotripsy with holmium laser enucleation of the prostate: a prospective feasibility study and review of literature","volume":"99","author":"Shah","year":"2007","journal-title":"BJU Int"},{"key":"R14-20240829","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.juro.2012.11.079","article-title":"Pathogenesis of bladder calculi in the presence of urinary stasis","volume":"189","author":"Childs","year":"2013","journal-title":"J Urol"},{"key":"R15-20240829","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0094-0143(02)00072-1","article-title":"Evaluating incontinence in women","volume":"29","author":"Flisser","year":"2002","journal-title":"Urol Clin North Am"},{"key":"R16-20240829","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.urology.2004.08.049","article-title":"Longitudinal study of men with mild symptoms of bladder outlet obstruction treated with watchful waiting for four years","volume":"64","author":"Djavan","year":"2004","journal-title":"Urology"},{"key":"R17-20240829","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.eururo.2009.09.035","article-title":"The effects of combination therapy with dutasteride and tamsulosin on clinical outcomes in men with symptomatic benign prostatic hyperplasia: 4-year results from the CombAT study","volume":"57","author":"Roehrborn","year":"2010","journal-title":"Eur Urol"},{"key":"R18-20240829","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1159\/000447224","article-title":"Clinical considerations for intravesical prostatic protrusion in the evaluation and management of bladder outlet obstruction secondary to benign prostatic hyperplasia","volume":"12","author":"Gandhi","year":"2018","journal-title":"Curr Urol"},{"key":"R19-20240829","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.urology.2014.06.038","article-title":"Intravesical prostatic protrusion is a risk factor for bladder stone in patients with benign prostatic hyperplasia","volume":"84","author":"Kim","year":"2014","journal-title":"Urology"},{"key":"R20-20240829","doi-asserted-by":"crossref","first-page":"e7728","DOI":"10.1097\/MD.0000000000007728","article-title":"Risk factors for bladder calculi in patients with benign prostatic hyperplasia","volume":"96","author":"Huang","year":"2017","journal-title":"Medicine (Baltimore)"}],"container-title":["Asian Journal of Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aja2022107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:01:08Z","timestamp":1787760068000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aja2022107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,27]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/aja2022107","relation":{},"ISSN":["1745-7262","1008-682X"],"issn-type":[{"value":"1745-7262","type":"print"},{"value":"1008-682X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,27]]},"assertion":[{"value":"2022-09-28","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-15","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}