{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:24:07Z","timestamp":1787757847124,"version":"build-2784847793"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:p>\n                    Cryptorchidism affects the growth of testicular volume. Testicular volume is associated with reproductive function. The testicular atrophy index evaluates the degree of damage caused by cryptorchidism, but it remains unclear whether changes in testicular atrophy index are related to age. We selected patients who underwent surgery for unilateral palpable cryptorchidism. Testicular volume was measured using ultrasonography. The testicular atrophy indices of the undescended testes were then reviewed, and their correlation with age was analyzed. We studied 228 cases (age range: 6\u201353 months). Scatter plots were constructed, and Loess curves were fitted, revealing a turning point at 24 months of age. The patients were divided into age groups of 6\u201324 months and 25\u201353 months. The testicular volume of the cryptorchid side was smaller than that of the normal side in both groups (both\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001). In the 6\u201324-month group, the testicular atrophy index was positively correlated with age, testicular volume on the cryptorchid side was not correlated with age, and testicular volume was positively correlated with age on the normal side. In the 25\u201353-month group, testicular atrophy index and testicular volumes on either side were not correlated with age. A palpable unilateral cryptorchid testis is smaller than the contralateral testis. The testicular atrophy index increases with age between 6 months and 24 months, but not between 25 months and 53 months. Testicular volume increased with age on the normal side between 6 months and 24 months, but not on the cryptorchid side. Trends in testicular atrophy index with age contribute to the decision of operation time.\n                  <\/jats:p>","DOI":"10.4103\/aja202227","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T06:46:56Z","timestamp":1653029216000},"page":"500-502","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Analysis of trends in testicular atrophy index values with age in patients with unilateral palpable cryptorchidism"],"prefix":"10.4103","volume":"24","author":[{"given":"Pei-Qiang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pediatric Urology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Urology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Yun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Urology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,9]]},"reference":[{"key":"B1-20240829","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.5489\/cuaj.4343","article-title":"Cryptorchidism: a practical review for all community healthcare providers","volume":"11","author":"Braga","year":"2017","journal-title":"Can Urol Assoc J"},{"key":"B2-20240829","doi-asserted-by":"crossref","first-page":"e924325","DOI":"10.12659\/MSM.924325","article-title":"Three-dimensional ultrasonography in preoperative and postoperative volume assessment of the undescended testicle","volume":"26","author":"You","year":"2020","journal-title":"Med Sci Monit"},{"key":"B3-20240829","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.urols.2016.08.003","article-title":"Volume alteration of undescended testes: before and after orchiopexy","volume":"27","author":"Tseng","year":"2016","journal-title":"Urol Sci"},{"key":"B4-20240829","first-page":"2713","article-title":"Testicular function in a birth cohort of young men","volume":"30","author":"Hart","year":"2015","journal-title":"Hum Reprod"},{"key":"B5-20240829","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1111\/and.12534","article-title":"Consequences of bilateral cryptorchidism in adults","volume":"48","author":"Adomaitis","year":"2016","journal-title":"Andrologia"},{"key":"B6-20240829","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.1210\/jc.2012-2325","article-title":"Boys with undescended testes: endocrine, volumetric and morphometric studies on testicular function before and after orchidopexy at nine months or three years of age","volume":"97","author":"Kollin","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"B7-20240829","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1016\/j.juro.2011.07.037","article-title":"Histological findings in patients with cryptorchidism and testis-epididymis nonfusion","volume":"186","author":"Kraft","year":"2011","journal-title":"J Urol"},{"key":"B8-20240829","first-page":"112","article-title":"The usefulness of testicular atrophy index in the assessment of undescended testicle-preliminary report","volume":"48","author":"Niedzielski","year":"2003","journal-title":"Rocz Akad Med Bialymst"},{"key":"B9-20240829","doi-asserted-by":"crossref","first-page":"e5731","DOI":"10.1097\/MD.0000000000005731","article-title":"The role of ultrasound in the management of undescended testes before and after orchidopexy \u2013 an update","volume":"95","author":"Jedrzejewski","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"B10-20240829","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.urology.2011.04.057","article-title":"Testicular catch up growth: the impact of orchiopexy age","volume":"78","author":"Kim","year":"2011","journal-title":"Urology"},{"key":"B11-20240829","doi-asserted-by":"crossref","first-page":"79","DOI":"10.5455\/medarh.2014.68.79-82","article-title":"Testicular volume and testicular atrophy index as predictors of functionality of unilaterally cryptorchid testis","volume":"68","author":"Zvizdic","year":"2014","journal-title":"Med Arch"},{"key":"B12-20240829","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1111\/andr.12507","article-title":"The volume of unilaterally undescended testis after hCG therapy compared to orchidopexy and combined methods","volume":"6","author":"Niedzielski","year":"2018","journal-title":"Andrology"},{"key":"B13-20240829","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1093\/humrep\/den021","article-title":"Ultrasonographically measured testicular volumes in 0- to 6-year-old boys","volume":"23","author":"Kuijper","year":"2008","journal-title":"Hum Reprod"},{"key":"B14-20240829","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1365-2605.1983.tb00333.x","article-title":"Quantification of germ cells and seminiferous tubules by stereological examination of testicles from 50 boys who suffered from sudden death","volume":"6","author":"M\u00fcller","year":"1983","journal-title":"Int J Androl"},{"key":"B15-20240829","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/j.1365-2605.1987.tb00358.x","article-title":"Proliferation of Sertoli cells during development of the human testis assessed by stereological methods","volume":"10","author":"Cortes","year":"1987","journal-title":"Int J Androl"},{"key":"B16-20240829","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1210\/jc.2005-2443","article-title":"Larger testes and higher inhibin B levels in Finnish than in Danish newborn boys","volume":"91","author":"Main","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"B17-20240829","first-page":"271","article-title":"Fluctuations in the number of germ cells during the late foetal and early postnatal periods in boys","volume":"105","author":"M\u00fcller","year":"1984","journal-title":"Acta Endocrinol (Copenh)"},{"key":"B18-20240829","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1055\/s-0036-1592197","article-title":"Surgical management of the undescended testis: recent advances and controversies","volume":"26","author":"Elder","year":"2016","journal-title":"Eur J Pediatr Surg"},{"key":"B19-20240829","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.juro.2009.04.032","article-title":"Age at orchiopexy and testis palpability predict germ and Leydig cell loss: clinical predictors of adverse histological features of cryptorchidism","volume":"182","author":"Tasian","year":"2009","journal-title":"J Urol"},{"key":"B20-20240829","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.juro.2007.03.173","article-title":"Surgical treatment of unilaterally undescended testes: testicular growth after randomization to orchiopexy at age 9 months or 3 years","volume":"178","author":"Kollin","year":"2007","journal-title":"J Urol"},{"key":"B21-20240829","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1097\/MOP.0000000000000335","article-title":"Undescended testes: an update","volume":"28","author":"Holland","year":"2016","journal-title":"Curr Opin Pediatr"}],"container-title":["Asian Journal of Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aja202227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:55:30Z","timestamp":1787756130000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aja202227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,20]]},"references-count":21,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/aja202227","relation":{},"ISSN":["1745-7262","1008-682X"],"issn-type":[{"value":"1745-7262","type":"print"},{"value":"1008-682X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,20]]},"assertion":[{"value":"2021-12-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-11","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}