{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:15:14Z","timestamp":1792167314698,"version":"4.4.0"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>\n                    The effects of the coronavirus disease 2019 (COVID-19) pandemic on male fertility have received considerable attention because human testes contain high levels of angiotensin-converting enzyme-2 receptors, through which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can enter. Early studies showed decreases in semen quality during and after recovery from COVID-19. However, no semen quality studies have examined the effects of widespread subclinical and mild disease, as well as changes in lifestyle, psychosocial behavior, intake of dietary supplements, and stress. This cross-sectional study compared semen quality parameters in male partners of infertile couples between men who underwent semen analysis before the COVID-19 pandemic (prepandemic group) and men who underwent semen analysis during the pandemic period (pandemic group); the analysis sought to clarify the overall effects of the pandemic. No participants in the pandemic group had experienced clinically overt disease. Among the 239 participants, mean body weight (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.001), mean body mass index (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001), median sperm concentration (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.014), total sperm count (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.006), and total percentages of motile (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.013) and abnormal cells (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001) were significantly greater in the pandemic group (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 137) than those in the prepandemic group (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 102). Among abnormal cells, the percentages of cells with excess residual cytoplasm (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001), head defects (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001), and tail defects (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.015) were significantly greater in the pandemic group than those in the prepandemic group. With the exception of morphology, the overall semenogram results were better in the pandemic group than those in the prepandemic group.\n                  <\/jats:p>","DOI":"10.4103\/aja202278","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T10:48:14Z","timestamp":1667299694000},"page":"240-244","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":14,"title":["Effects of the COVID-19 pandemic on semen quality in male partners of infertile couples: a hospital-based observational study"],"prefix":"10.4103","volume":"25","author":[{"given":"Tribhuwan","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Physiology, All India Institute of Medical Sciences, Patna 801507, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamlesh","family":"Jha","sequence":"additional","affiliation":[{"name":"Department of Physiology, All India Institute of Medical Sciences, Patna 801507, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md","family":"Zabihullah","sequence":"additional","affiliation":[{"name":"Department of Physiology, All India Institute of Medical Sciences, Patna 801507, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumari","family":"Neelu","sequence":"additional","affiliation":[{"name":"Akshat Spandan Clinic, Patna 801507, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Physiology, All India Institute of Medical Sciences, Patna 801507, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar","family":"Siddharth","sequence":"additional","affiliation":[{"name":"Department of Physiology, All India Institute of Medical Sciences, Patna 801507, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,11,1]]},"reference":[{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1001\/jamainternmed.2020.4130","article-title":"Seroprevalence of antibodies to SARS-CoV-2 in 10 sites in the United States, March 23-May 12, 2020","volume":"180","author":"Havers","year":"2020","journal-title":"JAMA Intern Med"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1016\/S0140-6736(22)00484-6","article-title":"Estimating global, regional, and national daily and cumulative infections with SARS-CoV-2 through Nov 14, 2021: a statistical analysis","volume":"399","author":"Barber","year":"2022","journal-title":"Lancet"},{"key":"R4-20240829","doi-asserted-by":"crossref","first-page":"e1003877","DOI":"10.1371\/journal.pmed.1003877","article-title":"Seroprevalence of IgG antibodies against SARS-CoV-2 among the general population and healthcare workers in India, June\u2013July 2021: a population-based cross-sectional study","volume":"18","author":"Murhekar","year":"2021","journal-title":"PLoS Med"},{"key":"R5-20240829","first-page":"e9540","article-title":"Effect of COVID-19 on the organs","volume":"12","author":"Jain","year":"2020","journal-title":"Cureus"},{"key":"R6-20240829","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41577-020-0331-4","article-title":"Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages","volume":"20","author":"Merad","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"R7-20240829","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0140-6736(20)30937-5","article-title":"Endothelial cell infection and endotheliitis in COVID-19","volume":"395","author":"Varga","year":"2020","journal-title":"Lancet"},{"key":"R8-20240829","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A pneumonia outbreak associated with a new coronavirus of probable bat origin","volume":"579","author":"Zhou","year":"2020","journal-title":"Nature"},{"key":"R9-20240829","doi-asserted-by":"crossref","first-page":"920","DOI":"10.3390\/cells9040920","article-title":"scRNA-seq profiling of human testes reveals the presence of the ACE2 receptor, a target for SARS-CoV-2 infection in spermatogonia, Leydig and Sertoli cells","volume":"9","author":"Wang","year":"2020","journal-title":"Cells"},{"key":"R10-20240829","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/path.1570","article-title":"Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. 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