{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T20:45:56Z","timestamp":1789937156281,"version":"4.0.1"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:p>\n                    To compare the impact of the scrotal\n                    <jats:italic toggle=\"yes\">vs<\/jats:italic>\n                    inguinal orchidopexy approach on the testicular function of infants with cryptorchidism, a randomized controlled trial was conducted involving boys who were 6\u201312 months old at surgery and were diagnosed with clinically palpable, inguinal undescended testis. Between June 2021 and December 2021, these boys at Fujian Maternity and Child Health Hospital (Fuzhou, China) and Fujian Children\u2019s Hospital (Fuzhou, China) were enrolled. Block randomization with a 1:1 allocation ratio was employed. The primary outcome was testicular function assessed by testicular volume, serum testosterone, anti-M\u00fcllerian hormone (AMH), and inhibin B (InhB) levels. Secondary outcomes included operative time, amount of intraoperative bleeding, and postoperative complications. Among 577 screened patients, 100 (17.3%) were considered eligible and enrolled in the study. Of the 100 children who completed the 1-year follow-up, 50 underwent scrotal orchidopexy and 50 underwent inguinal orchidopexy. The testicular volume, serum testosterone, AMH, and InhB levels in both groups increased markedly after surgery (all\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05), but there were no apparent differences between groups at 6 months and 12 months after operation (all P &gt; 0.05). No differences between the scrotal and inguinal groups were noted regarding the operative time (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.987) and amount of intraoperative bleeding (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.746). The overall complication rate (2.0%) of the scrotal group was slightly lower than that of the inguinal group (8.0%), although this difference was not statistically significant (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &gt; 0.05). Both scrotal and inguinal orchiopexy exerted protective effects on testicular function in children with cryptorchidism, with similar operative status and postoperative complications. Scrotal orchiopexy is an effective alternative to inguinal orchiopexy in children with cryptorchidism.\n                  <\/jats:p>","DOI":"10.4103\/aja202314","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T06:00:10Z","timestamp":1685080810000},"page":"745-749","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["The effect of scrotal versus inguinal orchiopexy on the testicular function of children with clinically palpable, inguinal undescended testis: a randomized controlled trial"],"prefix":"10.4103","volume":"25","author":[{"given":"Wen-Hua","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long-Yao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Urinary Surgery, Fujian Children\u2019s Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Shen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urinary Surgery, Fujian Children\u2019s Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Qiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urinary Surgery, Fujian Children\u2019s Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Ming","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,5,26]]},"reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/MED.0b013e32835ffc7d","article-title":"Cryptorchidism","volume":"20","author":"Lee","year":"2013","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1097\/MOP.0000000000000335","article-title":"Undescended testes:an update","volume":"28","author":"Holland","year":"2016","journal-title":"Curr Opin Pediatr"},{"key":"R3-20240829","first-page":"2597","article-title":"[Acquired undescended testes:treatment and consequences for future fertility","volume":"163","author":"van Brakel","year":"2019","journal-title":"Ned Tijdschr Geneeskd"},{"key":"R4-20240829","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/humupd\/dmm027","article-title":"Epidemiology and pathogenesis of cryptorchidism","volume":"14","author":"Virtanen","year":"2008","journal-title":"Hum Reprod Update"},{"key":"R5-20240829","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nrurol.2011.23","article-title":"Testicular descent:INSL3, testosterone, genes and the intrauterine milieu","volume":"8","author":"Bay","year":"2011","journal-title":"Nat Rev Urol"},{"key":"R6-20240829","doi-asserted-by":"crossref","first-page":"500","DOI":"10.4103\/aja202227","article-title":"Analysis of trends in testicular atrophy index values with age in patients with unilateral palpable cryptorchidism","volume":"24","author":"Li","year":"2022","journal-title":"Asian J Androl"},{"key":"R7-20240829","first-page":"21","article-title":"Cryptorchidism:aspects of fertility and neoplasms. 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