{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:31:31Z","timestamp":1786728691212,"version":"build-2736575974"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                    The regulation of spermatogonial proliferation and apoptosis is of great significance for maintaining spermatogenesis. The single-cell RNA sequencing (scRNA-seq) analysis of the testis was performed to identify genes upregulated in spermatogonia. Using scRNA-seq analysis, we identified the spermatogonia upregulated gene origin recognition complex subunit 6 (\n                    <jats:italic toggle=\"yes\">Orc6<\/jats:italic>\n                    ), which is involved in DNA replication and cell cycle regulation; its protein expression in the human and mouse testis was detected by western blot and immunofluorescence. To explore the potential function of\n                    <jats:italic toggle=\"yes\">Orc6<\/jats:italic>\n                    in spermatogonia, the C18-4 cell line was transfected with control or\n                    <jats:italic toggle=\"yes\">Orc6<\/jats:italic>\n                    siRNA. Subsequently, 5-ethynyl-2-deoxyuridine (EdU) and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assays, flow cytometry, and western blot were used to evaluate its effects on proliferation and apoptosis. It was revealed that ORC6 could promote proliferation and inhibit apoptosis of C18-4 cells. Bulk RNA sequencing and bioinformatics analysis indicated that\n                    <jats:italic toggle=\"yes\">Orc6<\/jats:italic>\n                    was involved in the activation of wingless\/integrated (Wnt)\/\u03b2-catenin signaling. Western blot revealed that the expression of \u03b2-catenin protein and its phosphorylation (Ser675) were significantly decreased when silencing the expression of ORC6. Our findings indicated that\n                    <jats:italic toggle=\"yes\">Orc6<\/jats:italic>\n                    was upregulated in spermatogonia, whereby it regulated proliferation and apoptosis by activating Wnt\/\u03b2-catenin signaling.\n                  <\/jats:p>","DOI":"10.4103\/aja202330","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T03:49:15Z","timestamp":1693885755000},"page":"46-56","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["scRNA-seq reveals that origin recognition complex subunit 6 regulates mouse spermatogonial cell proliferation and apoptosis via activation of Wnt\/\u03b2-catenin signaling"],"prefix":"10.4103","volume":"26","author":[{"given":"Shi-Wei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Andrology, Center for Men\u2019s Health, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University 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