{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:28:42Z","timestamp":1790782122931,"version":"4.1.0"},"reference-count":68,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Almost half of infertility cases involve male infertility. Understanding the consequence of a diagnosis of male infertility, as a sole or partial contributor to the couples\u2019 infertility, to the mental health of men is required to ensure clinical care meets their psychological needs. The aim of this systematic analysis was to synthesize the evidence regarding whether men diagnosed with male factor infertility experience greater psychological distress than (1) men described as fertile and (2) men in couples with other infertility diagnoses. Online databases were searched using a combination of Medical Subject Headings (MeSH) headings and keywords relating to male infertility and psychological distress. The search yielded 1016 unique publications, of which 23 were included: 8 case\u2013control, 14 prospective cohort, and 1 data linkage studies. Seven aspects of psychological distress were identified depression, anxiety, self-esteem, quality of life, fertility-related stress, general psychological stress or well-being, and psychiatric conditions. Case\u2013control studies reported that men with male factor infertility have more symptoms of depression, anxiety and general psychological distress, worse quality of some aspects of life, and lower self-esteem than controls. When men with male factor infertility were compared to men in couples with other causes of infertility, there were few differences in the assessed aspects of psychological distress. Despite methodological limitations within the studies, this systematic analysis suggests that the experience of infertility, irrespective of its cause, negatively affects men\u2019s mental health and demonstrates the need for assisted reproduction technology (ART) providers to consider men undergoing assisted reproduction as individuals with their own unique support needs.<\/jats:p>","DOI":"10.4103\/aja202334","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T02:51:10Z","timestamp":1692759070000},"page":"10-19","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":51,"title":["Psychological consequences of a diagnosis of infertility in men: a systematic analysis"],"prefix":"10.4103","volume":"26","author":[{"given":"Sarah N","family":"Biggs","sequence":"first","affiliation":[{"name":"Reproductive Epidemiology, Murdoch Children\u2019s Research Institute, Melbourne 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Halliday","sequence":"additional","affiliation":[{"name":"Reproductive Epidemiology, Murdoch Children\u2019s Research Institute, Melbourne 3052, Australia"},{"name":"Department of Paediatrics, University of Melbourne, Melbourne 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Hammarberg","sequence":"additional","affiliation":[{"name":"Public Health and Preventative Medicine, Monash University, Melbourne 3004, Australia"},{"name":"Victorian Assisted Reproductive Treatment Authority, Melbourne 3000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,8,22]]},"reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.fertnstert.2013.12.045","article-title":"\u201cPatient-centered fertility treatment\u201d: what is required?","volume":"101","author":"Dancet","year":"2014","journal-title":"Fertil Steril"},{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s12978-017-0375-5","article-title":"A conceptual framework for patient-centered fertility treatment","volume":"14","author":"Duthie","year":"2017","journal-title":"Reprod Health"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1093\/humrep\/dev177","article-title":"ESHRE guideline: routine psychosocial care in infertility and medically assisted reproduction-a guide for fertility staff","volume":"30","author":"Gameiro","year":"2015","journal-title":"Hum Reprod"},{"key":"R5-20240829","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.rbms.2021.10.003","article-title":"From generalist to specialist: a qualitative study of the perceptions of infertility patients","volume":"14","author":"Leyser-Whalen","year":"2022","journal-title":"Reprod Biomed Soc Online"},{"key":"R6-20240829","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1111\/jan.12058","article-title":"Psychological aspects of male fertility treatment","volume":"69","author":"Mikkelsen","year":"2013","journal-title":"J Adv Nurs"},{"key":"R7-20240829","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1093\/humrep\/deq259","article-title":"Men's experiences of infertility and infertility treatment 5 years after diagnosis of male factor infertility: a retrospective cohort study","volume":"25","author":"Hammarberg","year":"2010","journal-title":"Hum Reprod"},{"key":"R8-20240829","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/2158244015610319","article-title":"Experiencing male infertility: a review of the qualitative research literature","volume":"5","author":"Hanna","year":"2015","journal-title":"SAGE Open"},{"key":"R9-20240829","doi-asserted-by":"crossref","first-page":"10952","DOI":"10.18632\/aging.102497","article-title":"Global, regional, and national prevalence and disability-adjusted life-years for infertility in 195 countries and territories, 1990-2017: results from a global burden of disease study, 2017","volume":"11","author":"Sun","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"R10-20240829","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.fertnstert.2020.11.014","article-title":"Top 10 priorities for future infertility research: an international consensus development study","volume":"115","author":"Duffy","year":"2021","journal-title":"Fertil Steril"},{"key":"R11-20240829","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.fertnstert.2003.06.029","article-title":"Why do couples discontinue in vitro fertilization treatment? 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