{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:17:58Z","timestamp":1787771878306,"version":"build-2784847793"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>\n                    This study aimed to investigate the effects of male hepatitis B virus (HBV) infection on male fertility, embryonic development, and\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    fertilization\/intracytoplasmic sperm injection (IVF\/ICSI) outcomes. We performed a retrospective cohort study that included 3965 infertile couples who received fresh embryo transfer cycles for the first time at the Fujian Maternity and Child Health Hospital (Fuzhou, China) from January 2018 to January 2021. Infertile couples were categorized based on their HBV infection status into the HBV group (HBV-positive men and HBV-negative women) and the control group (HBV-negative couples). A 1:1 propensity score matching was performed with relatively balanced covariates. Baseline characteristics, semen parameters, laboratory outcomes, clinical outcomes, and obstetric and neonatal outcomes were compared between groups. After propensity score matching, 821 couples were included in each group. Both groups had similar semen parameters and obstetric and neonatal outcomes. The HBV group showed a significantly lower live birth rate than the control group (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05). The HBV group had a significantly higher abortion rate than the control group (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05). The rates of high-quality embryos and blastocyst formation were significantly lower in the HBV group than those in the control group (both\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05). In conclusion, in couples who undergo IVF\/ICSI, male HBV infection reduces the live birth rate and increases the risk of miscarriage. However, the incidence of low birth weight in women with IVF\/ICSI does not increase with male HBV infection.\n                  <\/jats:p>","DOI":"10.4103\/aja202382","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T01:01:50Z","timestamp":1707786110000},"page":"415-420","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Effect of male HBV infection on the outcomes of IVF\/ICSI cycles: a retrospective cohort study based on propensity score matching"],"prefix":"10.4103","volume":"26","author":[{"given":"Su-Qin","family":"Zhu","sequence":"first","affiliation":[{"name":"Fujian Provincial Reproductive Medicine Center, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, China"},{"name":"Fujian Key Laboratory of Prenatal Diagnosis and Birth Defect, Fuzhou 350001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Hua","family":"Liao","sequence":"additional","affiliation":[{"name":"Fujian Provincial Reproductive Medicine Center, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Wen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Fujian Provincial Reproductive Medicine Center, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[{"name":"Fujian Provincial Reproductive Medicine Center, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Ling","family":"Xu","sequence":"additional","affiliation":[{"name":"Fujian Provincial Reproductive Medicine Center, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"Fujian Provincial Reproductive Medicine Center, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei-Hong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Fujian Provincial Reproductive Medicine Center, Fujian Maternity and Child Health Hospital, 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