{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:35:08Z","timestamp":1787070908542,"version":"build-2736575974"},"reference-count":55,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Stem cell treatment may enhance erectile dysfunction (ED) in individuals with cavernous nerve injury (CNI). Nevertheless, no investigations have directly ascertained the implications of varying amounts of human umbilical cord-derived mesenchymal stem cells (HUC-MSCs) on ED. We compare the efficacy of three various doses of HUC-MSCs as a therapeutic strategy for ED. Sprague\u2013Dawley rats (total = 175) were randomly allocated into five groups. A total of 35 rats underwent sham surgery and 140 rats endured bilateral CNI and were treated with vehicles or doses of HUC-MSCs (1 \u00d7 10\n                    <jats:sup>6<\/jats:sup>\n                    cells, 5 \u00d7 10\n                    <jats:sup>6<\/jats:sup>\n                    cells, and 1 \u00d7 10\n                    <jats:sup>7<\/jats:sup>\n                    cells in 0.1 ml, respectively). Penile tissues were harvested for histological analysis on 1 day, 3 days, 7 days, 14 days, 28 days, 60 days, and 90 days postsurgery. It was found that varying dosages of HUC-MSCs enhanced the erectile function of rats with bilateral CNI and ED. Moreover, there was no significant disparity in the effectiveness of various dosages of HUC-MSCs. However, the expression of endothelial markers (rat endothelial cell antigen-1 [RECA-1] and endothelial nitric oxide synthase [eNOS]), smooth muscle markers (alpha smooth muscle actin [\u03b1-SMA] and desmin), and neural markers (neurofilament [RECA-1] and neurogenic nitric oxide synthase [nNOS]) increased significantly with prolonged treatment time. Masson\u2019s staining demonstrated an increased in the smooth muscle cell (SMC)\/collagen ratio. Significant changes were detected in the microstructures of various types of cells. In vivo imaging system (IVIS) analysis showed that at the 1\n                    <jats:sup>st<\/jats:sup>\n                    day, the HUC-MSCs implanted moved to the site of damage. Additionally, the oxidative stress levels were dramatically reduced in the penises of rats administered with HUC-MSCs.\n                  <\/jats:p>","DOI":"10.4103\/aja2024115","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T02:14:45Z","timestamp":1740708885000},"page":"508-515","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Effects of human umbilical cord-derived mesenchymal stem cell therapy for cavernous nerve injury-induced erectile dysfunction in the rat model"],"prefix":"10.4103","volume":"27","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[{"name":"School of Medicine, Southeast University, Nanjing 210000, China"},{"name":"Department of Urology, Xuzhou Central Hospital, Xuzhou 221000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory, Xuzhou Central Hospital, Xuzhou 221000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Hao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Urology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai 519000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Urology, Xuzhou Central Hospital, Xuzhou 221000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine, Jiangsu University, Zhenjiang 212000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Fei","family":"Huan","sequence":"additional","affiliation":[{"name":"Department of Urology, Xuzhou Central Hospital, Xuzhou 221000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Ru","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Genetics, Xuzhou Medical University, Xuzhou 221000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuo-Bin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Genetics, Xuzhou Medical University, Xuzhou 221000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong-Hui","family":"Han","sequence":"additional","affiliation":[{"name":"School of Medicine, Southeast University, Nanjing 210000, China"},{"name":"Department of Urology, Xuzhou Central Hospital, Xuzhou 221000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"R1-20250716","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.juro.2018.05.004","article-title":"Erectile dysfunction:AUA guideline","volume":"200","author":"Burnett","year":"2018","journal-title":"J Urol"},{"key":"R2-20250716","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1046\/j.1464-410x.1999.00142.x","article-title":"The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences","volume":"84","author":"Ayta","year":"1999","journal-title":"BJU Int"},{"key":"R3-20250716","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1001\/jama.2016.12284","article-title":"Erectile dysfunction","volume":"316","author":"Najari","year":"2016","journal-title":"JAMA"},{"key":"R4-20250716","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.eururo.2012.05.045","article-title":"Systematic review and meta-analysis of studies reporting urinary continence recovery after robot-assisted radical prostatectomy","volume":"62","author":"Ficarra","year":"2012","journal-title":"Eur Urol"},{"key":"R5-20250716","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1111\/bju.12228","article-title":"Penile rehabilitation after radical prostatectomy:what the evidence really says","volume":"112","author":"Fode","year":"2013","journal-title":"BJU Int"},{"key":"R6-20250716","first-page":"8609","article-title":"Stem cell therapies in post-prostatectomy erectile dysfunction:a critical review","volume":"24","author":"Mang\u0131r","year":"2017","journal-title":"Can J Urol"},{"key":"R7-20250716","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.sxmr.2017.12.008","article-title":"Stem cell therapy for erectile dysfunction","volume":"7","author":"Matz","year":"2019","journal-title":"Sex Med Rev"},{"key":"R8-20250716","doi-asserted-by":"crossref","first-page":"784","DOI":"10.3390\/cells8080784","article-title":"Mesenchymal stem cell migration and tissue repair","volume":"8","author":"Fu","year":"2019","journal-title":"Cells"},{"key":"R9-20250716","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/iwj.12569","article-title":"The regenerative role of adipose-derived stem cells (ADSC) in plastic and reconstructive surgery","volume":"14","author":"Naderi","year":"2017","journal-title":"Int Wound J"},{"key":"R10-20250716","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.clineuro.2018.07.013","article-title":"Neural stem cell therapy-brief review","volume":"173","author":"Grochowski","year":"2018","journal-title":"Clin Neurol Neurosurg"},{"key":"R11-20250716","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.3390\/ijms18091852","article-title":"Mesenchymal stem cell secretome:toward cell-free therapeutic strategies in regenerative medicine","volume":"18","author":"Vizoso","year":"2017","journal-title":"Int J Mol Sci"},{"key":"R12-20250716","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3390\/cells9030573","article-title":"Urine-derived stem cells:applications in regenerative and predictive medicine","volume":"9","author":"Bento","year":"2020","journal-title":"Cells"},{"key":"R13-20250716","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.eururo.2015.09.026","article-title":"Safety of intracavernous bone marrow-mononuclear cells for postradical prostatectomy erectile dysfunction:an open dose-escalation pilot study","volume":"69","author":"Yiou","year":"2016","journal-title":"Eur Urol"},{"key":"R14-20250716","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ebiom.2016.01.024","article-title":"Safety and potential effect of a single intracavernous injection of autologous adipose-derived regenerative cells in patients with erectile dysfunction following radical prostatectomy:an open-label phase I clinical trial","volume":"5","author":"Haahr","year":"2016","journal-title":"EBioMedicine"},{"key":"R15-20250716","first-page":"63024","article-title":"Intracavernous pressure recording in a cavernous nerve injury rat model","volume":"175","author":"Li","year":"2021","journal-title":"J Vis Exp"},{"key":"R16-20250716","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0140-6736(12)60520-0","article-title":"Erectile dysfunction","volume":"381","author":"Shamloul","year":"2013","journal-title":"Lancet"},{"key":"R17-20250716","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.eururo.2008.10.028","article-title":"Phosphodiesterase type 5 inhibitors in postprostatectomy erectile dysfunction:a critical analysis of the basic science rationale and clinical application","volume":"55","author":"Hatzimouratidis","year":"2009","journal-title":"Eur Urol"},{"key":"R18-20250716","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.3727\/096368916X691448","article-title":"Transplantation of human urine-derived stem cells transfected with pigment epithelium-derived factor to protect erectile function in a rat model of cavernous nerve injury","volume":"25","author":"Yang","year":"2016","journal-title":"Cell Transplant"},{"key":"R19-20250716","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jsxm.2019.12.002","article-title":"Dynamic changes in erectile function and histological architecture after intracorporal injection of human placental stem cells in a pelvic neurovascular injury rat model","volume":"17","author":"Gu","year":"2020","journal-title":"J Sex Med"},{"key":"R20-20250716","doi-asserted-by":"crossref","first-page":"630076","DOI":"10.3389\/fbioe.2021.630076","article-title":"Transplantation of human gingiva-derived mesenchymal stem cells ameliorates neurotic erectile dysfunction in a rat model","volume":"9","author":"Wu","year":"2021","journal-title":"Front Bioeng Biotechnol"},{"key":"R21-20250716","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12610-022-00156-w","article-title":"Lipopolysaccharide-preconditioned allogeneic adipose-derived stem cells improve erectile function in a rat model of bilateral cavernous nerve injury","volume":"32","author":"Zhang","year":"2022","journal-title":"Basic Clin Androl"},{"key":"R22-20250716","doi-asserted-by":"crossref","first-page":"14399","DOI":"10.18632\/aging.203057","article-title":"MicroRNA-126 engineered muscle-derived stem cells attenuate cavernosa injury-induced erectile dysfunction in rats","volume":"13","author":"Zou","year":"2021","journal-title":"Aging (Albany, NY)"},{"key":"R23-20250716","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/s13287-020-01788-3","article-title":"Probucol enhances the therapeutic efficiency of mesenchymal stem cells in the treatment of erectile dysfunction in diabetic rats by prolonging their survival time via Nrf2 pathway","volume":"11","author":"Wang","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"R24-20250716","doi-asserted-by":"crossref","first-page":"13345","DOI":"10.1096\/fj.202000102RR","article-title":"Mesenchymal stem cells-derived exosomal microRNA-21-5p downregulates PDCD4 and ameliorates erectile dysfunction in a rat model of diabetes mellitus","volume":"34","author":"Huo","year":"2020","journal-title":"FASEB J"},{"key":"R25-20250716","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.jsxm.2015.11.016","article-title":"Intravenous preload of mesenchymal stem cells rescues erectile function in a rat model of cavernous nerve injury","volume":"14","author":"Kadihasanoglu","year":"2017","journal-title":"J Sex Med"},{"key":"R26-20250716","doi-asserted-by":"crossref","first-page":"1019063","DOI":"10.3389\/fbioe.2022.1019063","article-title":"Comparison of the therapeutic effects of human umbilical cord blood-derived mesenchymal stem cells and adipose-derived stem cells on erectile dysfunction in a rat model of bilateral cavernous nerve injury","volume":"10","author":"Ti","year":"2022","journal-title":"Front Bioeng Biotechnol"},{"key":"R27-20250716","doi-asserted-by":"crossref","first-page":"116733","DOI":"10.1016\/j.lfs.2019.116733","article-title":"Human umbilical cord mesenchymal stem cells derived-exosomes in diseases treatment","volume":"233","author":"Yaghoubi","year":"2019","journal-title":"Life Sci"},{"key":"R28-20250716","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/MOU.0000000000000636","article-title":"Stem-cell regenerative medicine as applied to the penis","volume":"29","author":"Pozzi","year":"2019","journal-title":"Curr Opin Urol"},{"key":"R29-20250716","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3727\/096368913X667709","article-title":"Paracrine mechanisms of mesenchymal stem cell based therapy:current status and perspectives","volume":"23","author":"Liang","year":"2014","journal-title":"Cell Transplant"},{"key":"R30-20250716","doi-asserted-by":"crossref","first-page":"560","DOI":"10.4111\/kju.2011.52.8.560","article-title":"Spontaneous recovery of cavernous nerve crush injury","volume":"52","author":"Kim","year":"2011","journal-title":"Korean J Urol"},{"key":"R31-20250716","doi-asserted-by":"crossref","first-page":"4533","DOI":"10.3390\/molecules26154533","article-title":"An overview of NO signaling pathways in aging","volume":"26","author":"Pourbagher-Shahri","year":"2021","journal-title":"Molecules"},{"key":"R32-20250716","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1111\/bju.13981","article-title":"cAMP-dependent post-translational modification of neuronal nitric oxide synthase neuroprotects penile erection in rats","volume":"120","author":"Karakus","year":"2017","journal-title":"BJU Int"},{"key":"R33-20250716","doi-asserted-by":"crossref","first-page":"6354","DOI":"10.7150\/thno.34008","article-title":"Transplantation of induced pluripotent stem cell-derived mesenchymal stem cells improved erectile dysfunction induced by cavernous nerve injury","volume":"9","author":"Chen","year":"2019","journal-title":"Theranostics"},{"key":"R34-20250716","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1002\/jnr.23545","article-title":"Role of oxidative stress in surgical cavernous nerve injury in a rat model","volume":"93","author":"Wang","year":"2015","journal-title":"J Neurosci Res"},{"key":"R35-20250716","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1111\/j.1743-6109.2012.02716.x","article-title":"Role of oxidative stress in a rat model of radiation-induced erectile dysfunction","volume":"9","author":"Kimura","year":"2012","journal-title":"J Sex Med"},{"key":"R36-20250716","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.4103\/1673-5374.189197","article-title":"Antioxidative mechanism of Lycium barbarum polysaccharides promotes repair and regeneration following cavernous nerve injury","volume":"11","author":"Zhao","year":"2016","journal-title":"Neural Regen Res"},{"key":"R37-20250716","doi-asserted-by":"crossref","first-page":"102938","DOI":"10.1016\/j.redox.2023.102938","article-title":"Dimethyl fumarate ameliorates erectile dysfunction in bilateral cavernous nerve injury rats by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis of nerve via activation of Nrf2\/HO-1 signaling pathway","volume":"68","author":"Song","year":"2023","journal-title":"Redox Biol"},{"key":"R38-20250716","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4103\/aja202331","article-title":"Nitro-oleic acid ameliorates erectile dysfunction in a streptozotocin-induced rat model of diabetes by inhibiting oxidative stress and apoptosis and activating the NO\/cGMP pathway","volume":"26","author":"Zhao","year":"2024","journal-title":"Asian J Androl"},{"key":"R39-20250716","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1111\/jcmm.17394","article-title":"N-acetylcysteine improves diabetic associated erectile dysfunction in streptozotocin-induced diabetic mice by inhibiting oxidative stress","volume":"26","author":"Ma","year":"2022","journal-title":"J Cell Mol Med"},{"key":"R40-20250716","first-page":"1782953","article-title":"Eucommia ulmoides Oliv. leaf extract improves erectile dysfunction in streptozotocin-induced diabetic rats by protecting endothelial function and ameliorating hypothalamic-pituitary-gonadal axis function","author":"Fu","year":"2019","journal-title":"Evid Based Complement Alternat Med 2019"},{"key":"R41-20250716","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","article-title":"Targeting NF-\u03baB pathway for the therapy of diseases:mechanism and clinical study","volume":"5","author":"Yu","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"R42-20250716","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/andr.12757","article-title":"Restoration of erectile function by suppression of corporal apoptosis and oxidative stress with losartan in aged rats with erectile dysfunction","volume":"8","author":"Wang","year":"2020","journal-title":"Andrology"},{"key":"R43-20250716","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.urology.2017.10.008","article-title":"Spontaneous regeneration of nerve fiber and irreversibility of corporal smooth muscle fibrosis after cavernous nerve crush injury:evidence from serial transmission electron microscopy and intracavernous pressure","volume":"118","author":"Wu","year":"2018","journal-title":"Urology"},{"key":"R44-20250716","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.physbeh.2004.08.014","article-title":"Neural control of erection","volume":"83","author":"Giuliano","year":"2004","journal-title":"Physiol Behav"},{"key":"R45-20250716","doi-asserted-by":"crossref","first-page":"372","DOI":"10.4103\/aja.aja_82_17","article-title":"Role of inhibiting LIM-kinase2 in improving erectile function through suppression of corporal fibrosis in a rat model of cavernous nerve injury","volume":"20","author":"Park","year":"2018","journal-title":"Asian J Androl"},{"key":"R46-20250716","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/andr.12922","article-title":"Rectification of cavernosal fibrosis and veno-occlusive dysfunction by administration of suberoylanilide hydroxamic acid in a rat model of cavernosal nerve injury:comparison with a PDE5 inhibitor","volume":"9","author":"Cho","year":"2021","journal-title":"Andrology"},{"key":"R47-20250716","doi-asserted-by":"crossref","first-page":"e880","DOI":"10.52225\/narra.v4i2.880","article-title":"A potential treatment for erectile dysfunction:effect of platelet-rich plasma administration on axon and collagen regeneration in cavernous nerve injury","volume":"4","author":"Ismy","year":"2024","journal-title":"Narra J"},{"key":"R48-20250716","doi-asserted-by":"crossref","first-page":"e10568","DOI":"10.1002\/btm2.10568","article-title":"Ultrasound-targeted microbubble destruction mediates PDE5i\/NO integration for cavernosum remodeling and penile rehabilitation","volume":"8","author":"Yang","year":"2023","journal-title":"Bioeng Transl Med"},{"key":"R49-20250716","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.actbio.2016.01.014","article-title":"Sonic hedgehog delivery from self-assembled nanofiber hydrogels reduces the fibrotic response in models of erectile dysfunction","volume":"32","author":"Choe","year":"2016","journal-title":"Acta Biomater"},{"key":"R50-20250716","first-page":"96","article-title":"Fibrosis \u2013a common pathway to organ injury and failure","volume":"373","author":"Rockey","year":"2015","journal-title":"N Engl J Med"},{"key":"R51-20250716","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/s13287-019-1366-y","article-title":"Human amniotic mesenchymal stem cells and their paracrine factors promote wound healing by inhibiting heat stress-induced skin cell apoptosis and enhancing their proliferation through activating PI3K\/AKT signaling pathway","volume":"10","author":"Li","year":"2019","journal-title":"Stem Cell Res Ther"},{"key":"R52-20250716","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2019.04.002","article-title":"The mesenchymal stem cell secretome:a new paradigm towards cell-free therapeutic mode in regenerative medicine","volume":"46","author":"Praveen","year":"2019","journal-title":"Cytokine Growth Factor Rev"},{"key":"R53-20250716","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MNH.0b013e328333062c","article-title":"Mesenchymal stem cell interactions with growth factors on kidney repair","volume":"19","author":"Baer","year":"2010","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"R54-20250716","first-page":"3847171","article-title":"Mouse umbilical cord mesenchymal stem cell paracrine removes renal fibrosis in diabetic nephropathy by reducing myofibroblast transdifferentiation and cell proliferation and upregulating mmmps in mesangial cells","author":"Li","year":"2020","journal-title":"J Diabetes Res 2020"},{"key":"R55-20250716","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/stem.3140","article-title":"Extracellular vesicles and their roles in stem cell biology","volume":"38","author":"Hur","year":"2020","journal-title":"Stem Cells"}],"container-title":["Asian Journal of Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aja2024115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:38:42Z","timestamp":1787067522000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aja2024115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,28]]},"references-count":55,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/aja2024115","relation":{},"ISSN":["1745-7262","1008-682X"],"issn-type":[{"value":"1745-7262","type":"print"},{"value":"1008-682X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,28]]},"assertion":[{"value":"2024-08-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-02","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}