{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:23:39Z","timestamp":1787772219853,"version":"build-2784847793"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Microdissection testicular sperm extraction (mTESE) is commonly performed to retrieve sperm in the testes for assisted reproductive techniques in patients with idiopathic nonobstructive azoospermia (iNOA). However, the success rate of sperm retrieval varies among individuals. We aim to investigate the association between clinical parameters and sperm retrieval outcomes in patients with iNOA. We searched PubMed, EMBASE, and Web of Science from database inception to August 2, 2023. The main measure was whether sperm retrieval was successful in patients with iNOA who underwent mTESE. Pooled estimates of the sperm retrieval rate and weighted mean differences were calculated using random-effects models. The overall sperm retrieval rate was 36.8% (95% confidence interval [CI]: 27.5%\u201346.0%,\n                    <jats:italic toggle=\"yes\">I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 95.0%) in nine studies comprising 1892 patients with iNOA. No significant differences were found in age, testicular volume, serum total testosterone concentrations, or inhibin B concentrations between positive and negative sperm retrieval outcomes. Lower anti-M\u00fcllerian hormone concentrations in patients with iNOA were associated with a positive outcome of mTESE (weighted mean differences: \u22122.70; 95% CI: \u22123.94\u2013\u22121.46,\n                    <jats:italic toggle=\"yes\">I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 79.0%). In conclusion, this study shows a significant relationship between anti-M\u00fcllerian hormone and sperm retrieval outcomes in patients with iNOA, while age, testicular volume, total testosterone, and inhibin B show no significant association. These findings have important implications for assessing the potential success of sperm retrieval and selecting appropriate treatment strategies in patients with iNOA.\n                  <\/jats:p>","DOI":"10.4103\/aja202419","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:04:32Z","timestamp":1715645072000},"page":"522-527","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Association between anti-M\u00fcllerian hormone concentrations and sperm retrieval outcomes in patients with idiopathic nonobstructive azoospermia: a systematic review and meta-analysis"],"prefix":"10.4103","volume":"26","author":[{"given":"Hong","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Andrology and Sexual Medicine, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Lang","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Andrology and Sexual Medicine, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Andrology and Sexual Medicine, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Andrology and Sexual Medicine, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Lin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Andrology and Sexual Medicine, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Andrology and Sexual Medicine, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Liang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Andrology and Sexual Medicine, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song-Xi","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Andrology and Sexual Medicine, First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,5,14]]},"reference":[{"key":"R1-20240905","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.3390\/ijms22063264","article-title":"Genetics of azoospermia","volume":"22","author":"Cioppi","year":"2021","journal-title":"Int J Mol Sci"},{"key":"R2-20240905","doi-asserted-by":"crossref","first-page":"15","DOI":"10.6061\/clinics\/2013(Sup01)03","article-title":"The epidemiology and etiology of azoospermia","volume":"68","author":"Ocuzza","year":"2013","journal-title":"Clinics (Sao Paulo)"},{"key":"R3-20240905","doi-asserted-by":"crossref","first-page":"598","DOI":"10.4103\/aja2022111","article-title":"Development of a predictive model for increasing sperm retrieval success by microdissection testicular sperm extraction in patients with nonobstructive azoospermia","volume":"25","author":"Deng","year":"2023","journal-title":"Asian J Androl"},{"key":"R4-20240905","first-page":"84","article-title":"Factors influencing sperm retrieval rate of microdissection testicular sperm extraction in nonobstructive azoospermia patients with different etiologies:a retrospective study of 1157 patients","volume":"38","author":"Zhang","year":"2023","journal-title":"Hum Reprod"},{"key":"R5-20240905","doi-asserted-by":"crossref","first-page":"621","DOI":"10.4103\/aja2022125","article-title":"Efficacy of stepwise mini-incision microdissection testicular sperm extraction for nonobstructive azoospermia with varied etiologies","volume":"25","author":"Zhang","year":"2023","journal-title":"Asian J Androl"},{"key":"R6-20240905","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1007\/s11255-021-02979-4","article-title":"Microdissection testicular sperm extraction (micro-TESE) in men with infertility due to nonobstructive azoospermia:summary of current literature","volume":"53","author":"Achermann","year":"2021","journal-title":"Int Urol Nephrol"},{"key":"R7-20240905","doi-asserted-by":"crossref","first-page":"i89","DOI":"10.1093\/humrep\/dead093.174","article-title":"Factors influencing ICSI outcome after sperm retrieval in nonobstructive azoospermia patients with different types of etiologies:a retrospective study of 1157 patients","volume":"38","author":"Zhang","year":"2023","journal-title":"Hum Reprod"},{"key":"R8-20240905","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4103\/aja.aja_5_17","article-title":"Predictive value of FSH, testicular volume, and histopathological findings for the sperm retrieval rate of microdissection TESE in nonobstructive azoospermia:a meta-analysis","volume":"20","author":"Li","year":"2018","journal-title":"Asian J Androl"},{"key":"R9-20240905","doi-asserted-by":"crossref","first-page":"1109807","DOI":"10.3389\/fendo.2022.1109807","article-title":"Nomogram based on a circular RNA biomarker for predicting the likelihood of successful sperm retrieval via microdissection testicular sperm extraction in patients with idiopathic non-obstructive azoospermia","volume":"13","author":"Shi","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"R10-20240905","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1093\/humrep\/dead125","article-title":"Anti-m\u00fcllerian hormone predicts positive sperm retrieval in men with idiopathic non-obstructive azoospermia-findings from a multi-centric cross-sectional study","volume":"38","author":"Pozzi","year":"2023","journal-title":"Hum Reprod"},{"key":"R11-20240905","doi-asserted-by":"crossref","first-page":"1006208","DOI":"10.3389\/fendo.2022.1006208","article-title":"Outcomes and affecting factors for ICSI and microTESE treatments in nonobstructive azoospermia patients with different etiologies:a retrospective analysis","volume":"13","author":"Gao","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"R12-20240905","first-page":"i9","article-title":"Extremely low serum AMH level correlates with a high sperm retrieval rate of micro-TESE in men with idiopathic azoospermia","volume":"35","author":"Zhang","year":"2020","journal-title":"Hum Reprod"},{"key":"R13-20240905","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.kjms.2018.04.001","article-title":"The ghrelin and orexin activity in testicular tissues of patients with idiopathic non-obstructive azoospermia","volume":"34","author":"Ozkanli","year":"2018","journal-title":"Kaohsiung J Med Sci"},{"key":"R14-20240905","doi-asserted-by":"crossref","first-page":"17638","DOI":"10.1038\/s41598-017-17420-z","article-title":"Anti-M\u00fcllerian hormone-to-testosterone ratio is predictive of positive sperm retrieval in men with idiopathic non-obstructive azoospermia","volume":"7","author":"Alfano","year":"2017","journal-title":"Sci Rep"},{"key":"R15-20240905","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.mefs.2016.05.001","article-title":"Predictive value of serum inhibin-B levels as an indicator of the presence of testicular spermatozoa in non-obstructive azoospermia","volume":"21","author":"Alhalabi","year":"2016","journal-title":"Middle East Fertil Soc J"},{"key":"R16-20240905","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1177\/0962280216669183","article-title":"Optimally estimating the sample mean from the sample size, median, mid-range, and\/or mid-quartile range","volume":"27","author":"Luo","year":"2018","journal-title":"Stat Methods Med Res"},{"key":"R17-20240905","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1471-2288-14-135","article-title":"Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range","volume":"14","author":"Wan","year":"2014","journal-title":"BMC Med Res Methodol"},{"key":"R18-20240905","doi-asserted-by":"crossref","first-page":"e14303","DOI":"10.1111\/and.14303","article-title":"A systematic review and meta-analysis exploring the predictors of sperm retrieval in patients with non-obstructive azoospermia and chromosomal abnormalities","volume":"54","author":"Majzoub","year":"2022","journal-title":"Andrologia"},{"key":"R19-20240905","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4103\/aja.aja_83_18","article-title":"Regulation of anti-M\u00fcllerian hormone (AMH) in males and the associations of serum AMH with the disorders of male fertility","volume":"21","author":"Xu","year":"2019","journal-title":"Asian J Androl"},{"key":"R20-20240905","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1016\/j.fertnstert.2009.11.046","article-title":"Seminal plasma levels of anti-M\u00fcllerian hormone and inhibin B are not predictive of testicular sperm retrieval in nonobstructive azoospermia:a study of 139 men","volume":"94","author":"Mitchell","year":"2010","journal-title":"Fertil Steril"},{"key":"R21-20240905","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1210\/jc.2011-1697","article-title":"Circulating anti-M\u00fcllerian hormone levels in adult men are under a strong genetic influence","volume":"97","author":"Pietil\u00e4inen","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"R22-20240905","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.ajhg.2022.01.011","article-title":"Whole-exome sequencing improves the diagnosis and care of men with non-obstructive azoospermia","volume":"109","author":"Kherraf","year":"2022","journal-title":"Am J Hum Genet"},{"key":"R23-20240905","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12958-022-00936-z","article-title":"Identification of deleterious variants in patients with male infertility due to idiopathic non-obstructive azoospermia","volume":"20","author":"Tang","year":"2022","journal-title":"Reprod Biol Endocrinol"},{"key":"R24-20240905","doi-asserted-by":"crossref","first-page":"e0436522","DOI":"10.1128\/spectrum.04365-22","article-title":"Interaction between host and microbes in the semen of patients with idiopathic nonobstructive azoospermia","volume":"11","author":"Chen","year":"2023","journal-title":"Microbiol Spectr"},{"key":"R25-20240905","doi-asserted-by":"crossref","first-page":"150368","DOI":"10.1016\/j.scitotenv.2021.150368","article-title":"Glyphosate-induced gut microbiota dysbiosis facilitates male reproductive toxicity in rats","volume":"805","author":"Liu","year":"2022","journal-title":"Sci Total Environ"},{"key":"R26-20240905","first-page":"311","article-title":"Effect of varicocele repair in patients with nonobstructive azoospermia","volume":"62","author":"Takeshima","year":"2017","journal-title":"J Reprod Med"},{"key":"R27-20240905","doi-asserted-by":"crossref","first-page":"405","DOI":"10.21037\/tau.2019.06.17","article-title":"Sertoli cell only syndrome induced by a varicocele","volume":"8","author":"Kavoussi","year":"2019","journal-title":"Transl Androl Urol"},{"key":"R28-20240905","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.fertnstert.2020.11.016","article-title":"Diagnosis and treatment of infertility in men: AUA\/ASRM guideline part II","volume":"115","author":"Schlegel","year":"2021","journal-title":"Fertil Steril"},{"key":"R29-20240905","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/humupd\/dmy015","article-title":"The risk of TESE-induced hypogonadism:a systematic review and meta-analysis","volume":"24","author":"Eliveld","year":"2018","journal-title":"Hum Reprod Update"},{"key":"R30-20240905","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/humupd\/dmx008","article-title":"Sperm recovery and ICSI outcomes in Klinefelter syndrome:a systematic review and meta-analysis","volume":"23","author":"Corona","year":"2017","journal-title":"Hum Reprod Update"},{"key":"R31-20240905","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1007\/s11255-020-02529-4","article-title":"Predictors of surgical sperm retrieval in non-obstructive azoospermia:summary of current literature","volume":"52","author":"Arshad","year":"2020","journal-title":"Int Urol Nephrol"}],"container-title":["Asian Journal of Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aja202419","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:33:41Z","timestamp":1787769221000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aja202419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,14]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/aja202419","relation":{},"ISSN":["1745-7262","1008-682X"],"issn-type":[{"value":"1745-7262","type":"print"},{"value":"1008-682X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,14]]},"assertion":[{"value":"2023-11-22","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-26","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}