{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:18:26Z","timestamp":1788880706015,"version":"build-2803163510"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Peyronie\u2019s disease (PD) is a disorder characterized by fibrous plaque formation in the penile tissue that leads to curvature and complications in advanced stages. In this study, we aimed to compare four injectable induction agents for the establishment of a robust rat model of PD: transforming growth factor-\u03b21 (TGF-\u03b21), fibrin, sodium tetradecyl sulfate (STS) combined with TGF-\u03b21, and polidocanol (POL) combined with TGF-\u03b21. The results showed that injection of TGF-\u03b21 or fibrin into the tunica albuginea induced pathological endpoints without causing penile curvature. The STS + TGF-\u03b21 combination resulted in both histological and morphological alterations, but with a high incidence of localized necrosis that led to animal death. The POL + TGF-\u03b21 combination produced pathological changes and curvature comparable to STS + TGF-\u03b21 and led to fewer complications. In conclusion, fibrin, STS + TGF-\u03b21, and POL + TGF-\u03b21 all induced PD with a certain degree of penile curvature and histological fibrosis in rats. The POL + TGF-\u03b21 combination offered comparatively greater safety and clinical relevance and may have the greatest potential for PD research using model rats.<\/jats:p>","DOI":"10.4103\/aja202430","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T03:16:07Z","timestamp":1723518967000},"page":"96-100","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Injectable agents for the induction of Peyronie\u2019s disease in model rats: a comparative study"],"prefix":"10.4103","volume":"27","author":[{"given":"Guang-Jun","family":"Du","sequence":"first","affiliation":[{"name":"Department of Andrology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Yan","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Andrology, Nanjing Drum 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