{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T21:31:22Z","timestamp":1789248682454,"version":"build-2803163510"},"reference-count":61,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study assessed the feasibility of testis tissue cryopreservation (TTC) for fertility preservation in prepubescent boys with cryptorchidism. From January 2014 to December 2022, the University Hospital of Copenhagen (Rigshospitalet, Copenhagen, Denmark) implemented TTC for 56 boys with cryptorchidism to preserve their reproductive potential. Testis tissue samples were collected during orchiopexy (32 cases) or at subsequent follow-up procedures (24 cases), necessitated by an increased risk of infertility as indicated by hormonal assessments and\/or findings from initial surgical biopsies. Testis samples were procured for TTC and pathological analysis. The cohort had an average age of 1.3 (range: 0.3\u20133.8) years at the time of orchiopexy, with 91.1% presenting bilateral cryptorchidism. The study revealed a median germ cell count of 0.39 (range: 0\u20132.88) per seminiferous tubule, with germ cells detected in 98.0% of the bilateral biopsies and 100% of the unilateral, indicating a substantial potential for fertility in these immature tissues. A dark spermatogonia (Ad) was detected in 37 out of 56 patients evaluated, with a median Ad spermatogonia count of 0.027 (range: 0.002\u20130.158) per seminiferous tubule. A total of 30.2% of the samples lacked Ad spermatogonia, indicative of potential gonadotrophin insufficiency. The median hormone levels measured were as follows: follicle-stimulating hormone (FSH) at 0.69 (range: 0.16\u20132.5) U l\n                    <jats:sup>\u22121<\/jats:sup>\n                    , luteinizing hormone (LH) at 0.21 (range: 0.05\u20133.86) U l\n                    <jats:sup>\u22121<\/jats:sup>\n                    , and inhibin B at 126 (range: 17\u2013300) pg ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    . Despite early orchiopexy, 20%\u201325% of boys with cryptorchidism remain at risk for future infertility, substantiating the necessity of TTC as a precaution. The study highlights the need for refined predictive techniques to identify boys at higher risk of future infertility.\n                  <\/jats:p>","DOI":"10.4103\/aja202437","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T02:00:08Z","timestamp":1722304808000},"page":"610-616","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Testis tissue cryopreservation may be considered in boys with cryptorchidism"],"prefix":"10.4103","volume":"26","author":[{"given":"Linn Salto","family":"Mamsen","sequence":"first","affiliation":[{"name":"Department of Gynaecology, Fertility, and Obstetrics, Laboratory of Reproductive Biology, University Hospital of Copenhagen, Rigshospitalet, Copenhagen 2100, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Hildorf","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, University Hospital of Copenhagen, Rigshospitalet, Copenhagen 2100, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elissavet","family":"Ntemou","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Fertility, and Obstetrics, Laboratory of Reproductive Biology, University Hospital of Copenhagen, Rigshospitalet, Copenhagen 2100, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Fertility, and Obstetrics, Laboratory of Reproductive Biology, University Hospital of Copenhagen, Rigshospitalet, Copenhagen 2100, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Cortes","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen 2100, Denmark"},{"name":"Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Hvidovre, Hvidovre 2650, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Fedder","sequence":"additional","affiliation":[{"name":"Centre of Andrology and Fertility Clinic, Department D, Odense University Hospital, Odense 5000, Denmark"},{"name":"Research Unit of Human Reproduction, Department of Clinical Research, University of Southern Denmark, Odense 5000, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen","family":"Thorup","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, University Hospital of Copenhagen, Rigshospitalet, Copenhagen 2100, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen 2100, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus Yding","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen 2100, Denmark"},{"name":"Fertility Clinic, University Hospital of Copenhagen, Herlev and Gentofte Hospital, Herlev 2730, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,7,30]]},"reference":[{"key":"R1-20241031","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1093\/humrep\/dei331","article-title":"Cryopreservation of intact testicular tissue from boys with cryptorchidism","volume":"21","author":"Kvist","year":"2006","journal-title":"Hum Reprod"},{"key":"R2-20241031","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1093\/humrep\/dev190","article-title":"A European perspective on testicular tissue cryopreservation for fertility preservation in prepubertal and adolescent boys","volume":"30","author":"Picton","year":"2015","journal-title":"Hum Reprod"},{"key":"R3-20241031","doi-asserted-by":"crossref","first-page":"5223","DOI":"10.3390\/ijms20205223","article-title":"Oncofertility:pharmacological protection and immature testicular tissue (ITT)-based strategies for prepubertal and adolescent male cancer patients","volume":"20","author":"Ntemou","year":"2019","journal-title":"Int J Mol Sci"},{"key":"R4-20241031","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1093\/humrep\/dez043","article-title":"Testicular tissue cryopreservation:8 years of experience from a coordinated network of academic centers","volume":"34","author":"Valli-Pulaski","year":"2019","journal-title":"Hum Reprod"},{"key":"R5-20241031","doi-asserted-by":"crossref","first-page":"hoaa016","DOI":"10.1093\/hropen\/hoaa016","article-title":"Fertility preservation in boys:recent developments and new insights","volume":"2020","author":"Goossens","year":"2020","journal-title":"Hum Reprod open"},{"key":"R6-20241031","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/humrep\/dep371","article-title":"An experimental protocol for fertility preservation in prepubertal boys recently diagnosed with cancer:a report of acceptability and safety","volume":"25","author":"Ginsberg","year":"2010","journal-title":"Hum Reprod"},{"key":"R7-20241031","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1002\/pbc.25078","article-title":"Testicular tissue cryopreservation in prepubertal male children:an analysis of parental decision-making","volume":"61","author":"Ginsberg","year":"2014","journal-title":"Pediatr Blood Cancer"},{"key":"R8-20241031","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1159\/000511158","article-title":"Parental acceptance rate of testicular tissue cryopreservation in Danish boys with cryptorchidism","volume":"13","author":"Hildorf","year":"2019","journal-title":"Sex Dev"},{"key":"R9-20241031","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1093\/humrep\/17.12.3039","article-title":"Birth of offspring following transplantation of cryopreserved immature testicular pieces and in-vitro microinsemination","volume":"17","author":"Shinohara","year":"2002","journal-title":"Hum Reprod"},{"key":"R10-20241031","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1126\/science.aav2914","article-title":"Autologous grafting of cryopreserved prepubertal rhesus testis produces sperm and offspring","volume":"363","author":"Fayomi","year":"2019","journal-title":"Science"},{"key":"R11-20241031","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ymeth.2016.02.013","article-title":"Experimental testicular tissue banking to generate spermatogenesis in the future:a multidisciplinary team approach","volume":"99","author":"Sadri-Ardekani","year":"2016","journal-title":"Methods"},{"key":"R12-20241031","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3389\/fendo.2018.00299","article-title":"Selecting infants with cryptorchidism and high risk of infertility for optional adjuvant hormonal therapy and cryopreservation of germ cells:experience from a pilot study","volume":"9","author":"Thorup","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"key":"R13-20241031","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1097\/01.ju.0000095793.04232.d8","article-title":"The epidemiology of congenital cryptorchidism, testicular ascent and orchiopexy","volume":"170","author":"Barthold","year":"2003","journal-title":"J Urol"},{"key":"R14-20241031","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/BF00497811","article-title":"Semen quality and gonadotropin levels in patients operated upon for cryptorchidism","volume":"11","author":"Mayr","year":"1996","journal-title":"Pediatr Surg Int"},{"key":"R15-20241031","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S0090-4295(00)00560-4","article-title":"Early orchiopexy:prepubertal intratubular germ cell neoplasia and fertility outcome","volume":"56","author":"Engeler","year":"2000","journal-title":"Urology"},{"key":"R16-20241031","first-page":"21","article-title":"Cryptorchidism:aspects of fertility and neoplasms. A study including data of 1335 consecutive boys who underwent testicular biopsy simultaneously with surgery for cryptorchidism","volume":"55","author":"Cortes","year":"2001","journal-title":"Horm Res"},{"key":"R17-20241031","first-page":"6","article-title":"Importance of early postnatal germ cell maturation for fertility of cryptorchid males","volume":"55","author":"Hadziselimovic","year":"2001","journal-title":"Horm Res"},{"key":"R18-20241031","doi-asserted-by":"crossref","first-page":"194","DOI":"10.2164\/jandrol.106.000828","article-title":"Cryptorchidism and semen quality:a TEM and molecular study","volume":"28","author":"Moretti","year":"2007","journal-title":"J Androl"},{"key":"R19-20241031","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00345-009-0406-0","article-title":"Fertility potential after unilateral and bilateral orchiopexy for cryptorchidism","volume":"27","author":"Trsinar","year":"2009","journal-title":"World J Urol"},{"key":"R20-20241031","doi-asserted-by":"crossref","first-page":"e20152768","DOI":"10.1542\/peds.2015-2768","article-title":"Age at surgery and outcomes of an undescended testis","volume":"137","author":"Schneuer","year":"2016","journal-title":"Pediatrics"},{"key":"R21-20241031","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1046\/j.1464-410x.2000.00662.x","article-title":"Clinical, physical, sperm and hormonal data in 251 adults operated on for cryptorchidism in childhood","volume":"85","author":"Gracia","year":"2000","journal-title":"BJU Int"},{"key":"R22-20241031","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1046\/j.1464-410X.2003.04177.x","article-title":"Infertility despite surgery for cryptorchidism in childhood can be classified by patients with normal or elevated follicle-stimulating hormone and identified at orchidopexy","volume":"91","author":"Cortes","year":"2003","journal-title":"BJU Int"},{"key":"R23-20241031","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1097\/JU.0000000000000615","article-title":"Fertility potential is compromised in 20% to 25% of boys with non-syndromic cryptorchidism despite orchiopexy within the first year of life","volume":"203","author":"Hildorf","year":"2020","journal-title":"J Urol"},{"key":"R24-20241031","first-page":"11","article-title":"Abnormal germ cell development in cryptorchidism","volume":"55","author":"Huff","year":"2001","journal-title":"Horm Res"},{"key":"R25-20241031","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1530\/REP-11-0290","article-title":"Differential marker protein expression specifies rarefaction zone-containing human Adark spermatogonia","volume":"143","author":"von Kopylow","year":"2012","journal-title":"Reproduction"},{"key":"R26-20241031","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.scr.2017.11.011","article-title":"Human spermatogonial markers","volume":"25","author":"von Kopylow","year":"2017","journal-title":"Stem Cell Res"},{"key":"R27-20241031","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3109\/00365599009180352","article-title":"Histological versus stereological methods applied at spermatogonia during normal human development","volume":"24","author":"Cortes","year":"1990","journal-title":"Scand J Urol Nephrol"},{"key":"R28-20241031","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/j.juro.2013.01.058","article-title":"The relation between adult dark spermatogonia and other parameters of fertility potential in cryptorchid testes","volume":"190","author":"Thorup","year":"2013","journal-title":"J Urol"},{"issue":"Suppl 143","key":"R29-20241031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/apm.13247","article-title":"Clinical aspects of histological and hormonal parameters in boys with cryptorchidism:thesis for PhD degree","volume":"130","author":"Hildorf","year":"2022","journal-title":"APMIS"},{"key":"R30-20241031","first-page":"381","article-title":"A diminished postnatal surge of Ad spermatogonia in cryptorchid infants is additional evidence for hypogonadotropic hypogonadism","volume":"134","author":"Hadziselimovic","year":"2004","journal-title":"Swiss Med Wkly"},{"key":"R31-20241031","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s00345-004-0398-8","article-title":"Clinical epidemiology of testicular germ cell tumors","volume":"22","author":"Dieckmann","year":"2004","journal-title":"World J Urol"},{"key":"R32-20241031","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/ijc.21032","article-title":"Epidemiology of testicular cancer:an overview","volume":"116","author":"Garner","year":"2005","journal-title":"Int J cancer"},{"key":"R33-20241031","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1055\/s-0036-1592138","article-title":"Long-term follow-up after treatment of cryptorchidism","volume":"26","author":"Thorup","year":"2016","journal-title":"Eur J Pediatr Surg"},{"key":"R34-20241031","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/S2352-4642(18)30254-2","article-title":"Association between male genital anomalies and adult male reproductive disorders:a population-based data linkage study spanning more than 40 years","volume":"2","author":"Schneuer","year":"2018","journal-title":"Lancet Child Adolesc Health"},{"key":"R35-20241031","doi-asserted-by":"crossref","first-page":"11303","DOI":"10.1073\/pnas.91.24.11303","article-title":"Germline transmission of donor haplotype following spermatogonial transplantation","volume":"91","author":"Brinster","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"R36-20241031","doi-asserted-by":"crossref","first-page":"11298","DOI":"10.1073\/pnas.91.24.11298","article-title":"Spermatogenesis following male germ-cell transplantation","volume":"91","author":"Brinster","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"R37-20241031","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1095\/biolreprod66.1.21","article-title":"Germ cell transplantation in pigs","volume":"66","author":"Honaramooz","year":"2002","journal-title":"Biol Reprod"},{"key":"R38-20241031","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/humrep\/17.1.55","article-title":"Germ cell transplantation into X-irradiated monkey testes","volume":"17","author":"Schlatt","year":"2002","journal-title":"Hum Reprod"},{"key":"R39-20241031","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.3389\/fphys.2019.01155","article-title":"Propagation of spermatogonial stem cell-like cells from infant boys","volume":"10","author":"Dong","year":"2019","journal-title":"Front Physiol"},{"key":"R40-20241031","doi-asserted-by":"crossref","first-page":"5390","DOI":"10.3390\/ijms20215390","article-title":"Xeno-free propagation of spermatogonial stem cells from infant boys","volume":"20","author":"Dong","year":"2019","journal-title":"Int J Mol Sci"},{"key":"R41-20241031","doi-asserted-by":"crossref","first-page":"853482","DOI":"10.3389\/fendo.2022.853482","article-title":"Characterization and survival of human infant testicular cells after direct xenotransplantation","volume":"13","author":"Wang","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"R42-20241031","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1200\/JCO.2002.07.175","article-title":"Knowledge and experience regarding cancer, infertility, and sperm banking in younger male survivors","volume":"20","author":"Schover","year":"2002","journal-title":"J Clin Oncol"},{"key":"R43-20241031","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1159\/000351189","article-title":"Regeneration of spermatogenesis after testicular cancer chemotherapy","volume":"91","author":"Suzuki","year":"2013","journal-title":"Urol Int"},{"key":"R44-20241031","doi-asserted-by":"crossref","first-page":"854186","DOI":"10.3389\/fendo.2022.854186","article-title":"Testicular tissue banking for fertility preservation in young boys:which patients should be included?","volume":"13","author":"Delgouffe","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"R45-20241031","doi-asserted-by":"crossref","first-page":"7975","DOI":"10.3390\/ijms23147975","article-title":"Organotypic culture of testicular tissue from infant boys with cryptorchidism","volume":"23","author":"Wang","year":"2022","journal-title":"Int J Mol Sci"},{"key":"R46-20241031","first-page":"32","article-title":"Preserved seminiferous tubule integrity with spermatogonial survival and induction of Sertoli and Leydig cell maturation after long-term organotypic culture of prepubertal human testicular tissue","volume":"32","author":"de Michele","year":"2017","journal-title":"Hum Reprod"},{"key":"R47-20241031","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.fertnstert.2018.07.018","article-title":"Influence of temperature, serum, and gonadotropin supplementation in short- and long-term organotypic culture of human immature testicular tissue","volume":"110","author":"Medrano","year":"2018","journal-title":"Fertil Steril"},{"key":"R48-20241031","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1093\/humrep\/dez180","article-title":"Assessment of fresh and cryopreserved testicular tissues from (pre)pubertal boys during organ culture as a strategy for in vitro spermatogenesis","volume":"34","author":"Portela","year":"2019","journal-title":"Hum Reprod"},{"key":"R49-20241031","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/s41422-020-0283-z","article-title":"In vitro testicular organogenesis from human fetal gonads produces fertilization-competent spermatids","volume":"30","author":"Yuan","year":"2020","journal-title":"Cell Res"},{"key":"R50-20241031","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.ucl.2004.04.009","article-title":"Cryptorchidism:diagnosis, treatment, and long-term prognosis","volume":"31","author":"Kolon","year":"2004","journal-title":"Urol Clin North Am"},{"key":"R51-20241031","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jpurol.2016.07.014","article-title":"Management of undescended testes: European Association of Urology\/European Society for Paediatric Urology guidelines","volume":"12","author":"Radmayr","year":"2016","journal-title":"J Pediatr Urol"},{"key":"R52-20241031","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/j.1651-2227.2006.00159.x","article-title":"Nordic consensus on treatment of undescended testes","volume":"96","author":"Ritz\u00e9n","year":"2007","journal-title":"Acta Paediatr"},{"key":"R53-20241031","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12610-021-00152-6","article-title":"Temperature is not a major factor in the differentiation of gonocytes into ad spermatogonia and fertility outcome in congenitally cryptorchid boys","volume":"32","author":"Hadziselimovic","year":"2022","journal-title":"Basic Clin Androl"},{"key":"R54-20241031","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000443741","article-title":"Opinion:comment on evaluation and treatment of cryptorchidism: AUA\/AAP and Nordic Consensus guidelines","volume":"96","author":"Hadziselimovic","year":"2016","journal-title":"Urol Int"},{"key":"R55-20241031","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/S0140-6736(01)06274-2","article-title":"The importance of both an early orchidopexy and germ cell maturation for fertility","volume":"358","author":"Hadziselimovic","year":"2001","journal-title":"Lancet"},{"key":"R56-20241031","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.juro.2012.04.025","article-title":"Undescended testis histology correlation with adult hormone levels and semen analysis","volume":"188","author":"Kraft","year":"2012","journal-title":"J Urol"},{"key":"R57-20241031","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1055\/s-2007-993194","article-title":"Testicular histology related to fertility outcome and postpubertal hormone status in cryptorchidism","volume":"220","author":"Hadziselimovic","year":"2008","journal-title":"Klin Padiatr"},{"key":"R58-20241031","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1093\/humrep\/dex306","article-title":"Development of the testis in pre-pubertal boys with cancer after biopsy for fertility preservation","volume":"32","author":"Uijldert","year":"2017","journal-title":"Hum Reprod"},{"key":"R59-20241031","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.rbmo.2022.01.014","article-title":"Testicular biopsy for fertility preservation in early-diagnosed klinefelter patients:patient characteristics and long-term follow-up","volume":"44","author":"Braye","year":"2022","journal-title":"Reprod Biomed Online"},{"key":"R60-20241031","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/humrep\/dead243","article-title":"Results from the first autologous grafting of adult human testis tissue","volume":"39","author":"Jensen","year":"2023","journal-title":"Hum Reprod"},{"key":"R61-20241031","first-page":"675","article-title":"Longitudinal reproductive hormone profiles in infants:peak of inhibin B levels in infant boys exceeds levels in adult men","volume":"83","author":"Andersson","year":"1998","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Asian Journal of Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aja202437","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:41:36Z","timestamp":1787067696000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aja202437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,30]]},"references-count":61,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/aja202437","relation":{},"ISSN":["1745-7262","1008-682X"],"issn-type":[{"value":"1745-7262","type":"print"},{"value":"1008-682X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,30]]},"assertion":[{"value":"2023-11-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-06","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}