{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:22:20Z","timestamp":1787847740898,"version":"build-2784847793"},"reference-count":100,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T00:00:00Z","timestamp":1724112000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Pericytes are multifunctional mural cells that surround the abluminal wall of endothelial cells and are associated with vascular development, vascular permeability, and angiogenesis. Additionally, pericytes demonstrate stem cell-like properties and contribute to neuroinflammatory processes. Pericytes have been extensively studied in the central nervous system. However, specific mechanisms underlying its involvement in various physiological and pathological conditions, especially in erectile dysfunction (ED), remain poorly understood. Advancements\n                    <jats:italic toggle=\"yes\">in in vitro<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    techniques, such as single-cell RNA sequencing, are expanding our understanding of pericytes. Recent studies have shown that pericyte dysfunction is considered an important factor in the pathogenesis of vascular and neurological ED. Therefore, this study aims to analyze the specific role of pericytes in ED, focusing on diabetic and neurogenic ED. This article provides a comprehensive review of research findings on PubMed from 2000 to 2023, concerning pericyte dysfunction in the process of ED, offering valuable insights, and suggesting directions for further research.\n                  <\/jats:p>","DOI":"10.4103\/aja202455","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T07:00:24Z","timestamp":1724137224000},"page":"13-19","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Role of pericytes in regulating penile angiogenesis and nerve regeneration"],"prefix":"10.4103","volume":"27","author":[{"given":"Guo Nan","family":"Yin","sequence":"first","affiliation":[{"name":"National Research Center for Sexual Medicine and Department of Urology, Inha University School of Medicine, Incheon 22332, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Kan","family":"Ryu","sequence":"additional","affiliation":[{"name":"National Research Center for Sexual Medicine and Department of Urology, Inha University School of Medicine, Incheon 22332, Korea"},{"name":"Program in Biomedical Science and Engineering, Inha University, Incheon 22212, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,8,20]]},"reference":[{"key":"R1-20250304","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0094-0143(21)00692-3","article-title":"The penis as a vascular organ. The importance of corporal smooth muscle tone in the control of erection","volume":"22","author":"Christ","year":"1995","journal-title":"Urol Clin North Am"},{"key":"R2-20250304","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ucl.2005.08.007","article-title":"Physiology of penile erection and pathophysiology of erectile dysfunction","volume":"32","author":"Dean","year":"2005","journal-title":"Urol Clin North Am"},{"key":"R3-20250304","doi-asserted-by":"crossref","first-page":"4302","DOI":"10.1038\/s41467-022-31950-9","article-title":"Single-cell transcriptome atlas of the human corpus cavernosum","volume":"13","author":"Zhao","year":"2022","journal-title":"Nat Commun"},{"key":"R4-20250304","doi-asserted-by":"crossref","first-page":"10891","DOI":"10.1038\/srep10891","article-title":"The pericyte as a cellular regulator of penile erection and a novel therapeutic target for erectile dysfunction","volume":"5","author":"Yin","year":"2015","journal-title":"Sci 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