{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:45:35Z","timestamp":1790621135584,"version":"4.1.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We aim to study the semen carriage of human papillomavirus (HPV) and evaluate its association with patient characteristics. We conduct a single-center cohort study at Amiens University Hospital Center (Amiens, France). From May 1 to October 31, 2021, 461 men consulting for infertility and with semen analysis data were included. Each participant gave his written informed consent for the use of laboratory, demographic, clinical, and lifestyle data. A proportion of the semen samples were sent to a virology laboratory for HPV screening in a polymerase chain reaction (PCR) assay. In univariate and multivariate analyses with a logistic regression model, HPV\n                    <jats:sup>+<\/jats:sup>\n                    and HPV\n                    <jats:sup>\u2212<\/jats:sup>\n                    groups were compared with regard to semen characteristics (including the DNA fragmentation index and the sperm decondensation index) and demographic, clinical, and lifestyle variables. Semen HPV carriage was detected in 22.3% of the patients. High-oncogenic-risk HPV genotypes were predominant (57.6%). Multivariate analysis showed that HPV carriage was significantly associated with the presence of at least one abnormal spermogram dinging (according to the 6\n                    <jats:sup>th<\/jats:sup>\n                    World Health Organization criteria), with an adjusted odds ratio (OR) of 4.10 (95% confidence interval [CI]: 2.32\u20137.25,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001). A statistically significant association was also found for the type of infertility (OR: 1.61, 95% CI: 1.00\u20132.57,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.05), the presence of varicocele (OR: 3.99, 95% CI: 1.48\u201310.71,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.01), and a history of cryptorchidism, testicular ectopia, or monorchidism (OR: 3.54, 95% CI: 1.07\u201311.66,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.04). Infection with a single HPV genotype or multiple HPV genotypes was significantly associated with at least one abnormal spermogram finding for all HPV oncogenic risk groups (OR: 3.93, 95% CI: 2.08\u20137.41,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001; and OR: 4.11, 95% CI: 1.58\u201310.68,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.01, respectively). The association between sperm HPV carriage and the risk of infertility was statistically significant in a multivariate analysis (OR: 5.63, 95% CI: 3.16\u201310.01,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001) and after adjustment for the propensity score (OR: 6.10, 95% CI: 3.33\u201311.21,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001). Our results suggest that semen HPV carriage has an impact on male fertility. Sperm screening for HPV might be a useful addition to the work-up for male infertility.\n                  <\/jats:p>","DOI":"10.4103\/aja202458","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T08:00:17Z","timestamp":1729584017000},"page":"196-203","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Human papillomavirus carriage in the semen of men consulting for infertility: prevalence and correlations with sperm characteristics"],"prefix":"10.4103","volume":"27","author":[{"given":"Armin","family":"Priam","sequence":"first","affiliation":[{"name":"Urology Department, Amiens University Hospital Center, Amiens 80000, France"},{"name":"Reproductive Medicine Department, Amiens University Hospital Center, Amiens 80000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine Le","family":"Bozec","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Kremlin Bic\u00eatre Hospital, Paris-Saclay University, Le Kremlin-Bic\u00eatre 94270, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasco Dias","family":"Meireles","sequence":"additional","affiliation":[{"name":"AGIR Research Unit 4294, Picardie-Jules Verne University, Amiens 80000, France"},{"name":"Virology Department, Amiens University Hospital Center, Amiens 80000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Saint","sequence":"additional","affiliation":[{"name":"Urology Department, Amiens University Hospital Center, Amiens 80000, France"},{"name":"EPROAD Research Unit 4669, Picardie-Jules Verne University, Amiens 80000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalie","family":"Cabry","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Department, Amiens University Hospital Center, Amiens 80000, France"},{"name":"PERITOX Research Unit UMR-I-01, Picardie-Jules Verne University, Amiens 80000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moncef","family":"Benkhalifa","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Department, Amiens University Hospital Center, Amiens 80000, France"},{"name":"PERITOX Research Unit UMR-I-01, Picardie-Jules Verne University, Amiens 80000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baptiste","family":"Demey","sequence":"additional","affiliation":[{"name":"AGIR Research Unit 4294, Picardie-Jules Verne University, Amiens 80000, France"},{"name":"Virology Department, Amiens University Hospital Center, Amiens 80000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorian","family":"Bosquet","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Department, Amiens University Hospital Center, Amiens 80000, France"},{"name":"PERITOX Research Unit UMR-I-01, Picardie-Jules Verne University, Amiens 80000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"issue":"Suppl 1","key":"R1-20250303","first-page":"1","article-title":"The epidemiology of genital human papillomavirus infection","volume":"24","author":"Trottier","year":"2006","journal-title":"Vaccine"},{"key":"R2-20250303","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.bpobgyn.2017.08.015","article-title":"The natural history of human papillomavirus infection","volume":"47","author":"De Sanjos\u00e9","year":"2018","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"R3-20250303","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1093\/infdis\/jis181","article-title":"Male human papillomavirus prevalence and association with condom use in Brazil, Mexico, and the United States","volume":"205","author":"Repp","year":"2012","journal-title":"J Infect 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infections among heterosexual men and women with multiple sexual partners:a prospective study","volume":"70","author":"Van Doornum","year":"1994","journal-title":"Genitourin Med"}],"container-title":["Asian Journal of 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