{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:55:35Z","timestamp":1790621735234,"version":"4.1.0"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Peyronie\u2019s disease (PD) presents a multifaceted challenge in contemporary urological practice, marked by penile deformity, pain, and the potential for erectile dysfunction. We meticulously explored the existing literature of intralesional\/topical interventions, aiming to provide clinicians with a nuanced understanding of available options for comprehensive PD management. To conduct this review, we performed a systematic search using the PubMed, Scopus, and ScienceDirect databases, including the keywords of combination of the \u201cPeyronie\u2019s disease\/plastic induration of the penis (PIP) and intralesional\/topical treatments\u201d. The study selection was based on adherence to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, resulting in the inclusion of 16 articles. We delve into the effectiveness and safety profiles of collagenase\n                    <jats:italic toggle=\"yes\">Clostridium histolyticum<\/jats:italic>\n                    (CCH), interferon, platelet-rich plasma (PRP), hyaluronic acid, botulinum toxin, stem cell, extracorporeal shock wave therapy (ESWT), and traction therapy, assessing their impact on penile curvature, length improvement, and patient-reported symptoms and outcomes. The best options evaluated are intralesional injections of CCH and penile traction devices, alone or in combination. Despite PD remains a challenge for urologists, the objective of this review is to contribute to the evolving landscape of PD management, fostering informed decision-making, and personalized care for individuals grappling with this challenging condition.\n                  <\/jats:p>","DOI":"10.4103\/aja202460","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T18:28:26Z","timestamp":1724437706000},"page":"156-165","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Intralesional and topical treatments for Peyronie\u2019s disease: a narrative review of current knowledge"],"prefix":"10.4103","volume":"27","author":[{"given":"Antonio","family":"Minore","sequence":"first","affiliation":[{"name":"Department of Urology, Campus Bio-Medico, University of Rome, Rome 00128, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loris","family":"Cacciatore","sequence":"additional","affiliation":[{"name":"Department of Urology, Campus Bio-Medico, University of Rome, Rome 00128, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Presicce","sequence":"additional","affiliation":[{"name":"Department of Urology, San Filippo Neri Hospital, Rome 00135, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Iannuzzi","sequence":"additional","affiliation":[{"name":"Department of Urology, Campus Bio-Medico, University of Rome, Rome 00128, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Testa","sequence":"additional","affiliation":[{"name":"Department of Urology, Campus Bio-Medico, University of Rome, Rome 00128, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Raso","sequence":"additional","affiliation":[{"name":"Department of Urology, Campus Bio-Medico, University of Rome, Rome 00128, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"Papalia","sequence":"additional","affiliation":[{"name":"Department of Urology, Campus Bio-Medico, University of Rome, Rome 00128, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Martini","sequence":"additional","affiliation":[{"name":"Department of Urology, San Filippo Neri Hospital, Rome 00135, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Mario","family":"Scarpa","sequence":"additional","affiliation":[{"name":"Department of Urology, Campus Bio-Medico, University of Rome, Rome 00128, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Esperto","sequence":"additional","affiliation":[{"name":"Department of Urology, Campus Bio-Medico, University of Rome, Rome 00128, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"key":"R1-20250303","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/sj.ijir.3900875","article-title":"Pathophysiology of Peyronie's disease","volume":"14","author":"Moreland","year":"2002","journal-title":"Int J Impot Res"},{"key":"R2-20250303","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1046\/j.1464-410X.1996.14120.x","article-title":"Francois de LaPeyronie (1978-1747):the man and the disease he described","volume":"78","author":"Dunsmuir","year":"1996","journal-title":"Br J Urol"},{"key":"R3-20250303","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/sj.ijir.3900863","article-title":"Epidemiology of Peyronie's disease","volume":"14","author":"Sommer","year":"2002","journal-title":"Int J Impot Res"},{"key":"R4-20250303","doi-asserted-by":"crossref","first-page":"399","DOI":"10.5534\/wjmh.200065","article-title":"The natural history of Peyronie's disease","volume":"39","author":"Di Maida","year":"2021","journal-title":"World J Mens Health"},{"key":"R5-20250303","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1111\/j.1743-6109.2008.00895.x","article-title":"The chronology of depression and distress in men with Peyronie's disease","volume":"5","author":"Nelson","year":"2008","journal-title":"J Sex Med"},{"key":"R7-20250303","doi-asserted-by":"crossref","first-page":"206284","DOI":"10.1155\/2012\/206284","article-title":"Peyronie's disease:still a surgical disease","volume":"2012","author":"Martinez","year":"2012","journal-title":"Adv Urol"},{"key":"R8-20250303","doi-asserted-by":"crossref","first-page":"qdad145","DOI":"10.1093\/jsxmed\/qdad145","article-title":"Patients'attitude with surgery for Peyronie's disease:results from a multicentric European study","volume":"21","author":"Capogrosso","year":"2023","journal-title":"J Sex Med"},{"key":"R10-20250303","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1080\/17512433.2021.1903873","article-title":"Peyronie's disease:pharmacological treatments and limitations","volume":"14","author":"Li","year":"2021","journal-title":"Expert Rev Clin Pharmacol"},{"key":"R11-20250303","doi-asserted-by":"crossref","first-page":"b2700","DOI":"10.1136\/bmj.b2700","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions:explanation and elaboration","volume":"339","author":"Liberati","year":"2009","journal-title":"BMJ"},{"key":"R12-20250303","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.sxmr.2018.02.005","article-title":"Penile traction therapy and vacuum erection devices in Peyronie's disease","volume":"7","author":"Avant","year":"2019","journal-title":"Sex Med Rev"},{"key":"R13-20250303","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/j.jsxm.2018.08.012","article-title":"Sildenafil 25 mg ODT +collagenase Clostridium hystoliticum versus collagenase Clostridium hystoliticum alone for the management of Peyronie's disease:a matched-pair comparison analysis","volume":"15","author":"Cocci","year":"2018","journal-title":"J Sex Med"},{"key":"R14-20250303","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1097\/JU.0000000000000743","article-title":"Long-term safety and curvature deformity characterization in patients previously treated with collagenase Clostridium histolyticum for Peyronie's disease","volume":"203","author":"Goldstein","year":"2020","journal-title":"J Urol"},{"key":"R15-20250303","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.jsxm.2017.08.008","article-title":"Safety and efficacy of collagenase Clostridium histolyticum in the treatment of acute-phase Peyronie's disease","volume":"14","author":"Nguyen","year":"2017","journal-title":"J Sex Med"},{"key":"R16-20250303","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/andr.12302","article-title":"Survey of patient and partner satisfaction following collagenase Clostridium histolyticumtreatment for Peyronie's disease","volume":"5","author":"Anaissie","year":"2017","journal-title":"Andrology"},{"key":"R18-20250303","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0090-4295(97)00700-0","article-title":"Use of intralesional verapamil to dissolve Peyronie's disease plaque:a long-term single-blind study","volume":"51","author":"Rehman","year":"1998","journal-title":"Urology"},{"key":"R19-20250303","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s11255-009-9522-4","article-title":"Effect of intralesional verapamil for treatment of Peyronie's disease:a randomized single-blind, placebo-controlled study","volume":"41","author":"Shirazi","year":"2009","journal-title":"Int Urol Nephrol"},{"key":"R20-20250303","first-page":"417","article-title":"Possibility of using the piezoelectric lithotriptor in the treatment of severe cavernous fibrosis","volume":"61","author":"Bellorofonte","year":"1989","journal-title":"Arch Ital Urol Nefrol Androl"},{"key":"R21-20250303","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/ijir.2016.24","article-title":"A meta-analysis of extracorporeal shock wave therapy for Peyronie's disease","volume":"28","author":"Gao","year":"2016","journal-title":"Int J Impot Res"},{"key":"R22-20250303","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00345-019-02818-3","article-title":"Sixty years in the making:collagenase Clostridium histolyticum, from benchtop to FDA approval and beyond","volume":"38","author":"Mills","year":"2020","journal-title":"World J Urol"},{"key":"R23-20250303","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/JU.0000000000000032","article-title":"Intralesional collagenase Clostridium histolyticum causes meaningful improvement in men with Peyronie's disease:results of a multi-institutional analysis","volume":"201","author":"Hellstrom","year":"2019","journal-title":"J Urol"},{"key":"R24-20250303","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1097\/JU.0000000000002789","article-title":"Acute lower back pain after intralesional injection of collagenase Clostridium histolyticumfor Peyronie's disease","volume":"208","author":"Sigalos","year":"2022","journal-title":"J Urol"},{"issue":"Suppl 2","key":"R25-20250303","doi-asserted-by":"crossref","first-page":"S269","DOI":"10.21037\/tau.2019.08.06","article-title":"Minimally invasive therapies for Peyronie's disease:the current state of the art","volume":"9","author":"Farrell","year":"2020","journal-title":"Transl Androl Urol"},{"key":"R26-20250303","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.juro.2013.09.037","article-title":"Re:clinical efficacy, safety and tolerability of collagenase Clostridium histolyticum for the treatment of peyronie disease in 2 large double-blind, randomized, placebo controlled phase 3 studies","volume":"191","author":"Jain","year":"2014","journal-title":"J Urol"},{"key":"R27-20250303","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/bju.14410","article-title":"Predictors of treatment success after collagenase Clostridium histolyticum injection for Peyronie's disease:development of a nomogram from a multicentre single-arm, non-placebo controlled clinical study","volume":"122","author":"Cocci","year":"2018","journal-title":"BJU Int"},{"key":"R28-20250303","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.urology.2020.05.076","article-title":"Treatment-related outcomes for patients with atypical Peyronie's disease using xiaflex injections","volume":"143","author":"El-Khatib","year":"2020","journal-title":"Urology"},{"key":"R29-20250303","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/jsxmed\/qdac030","article-title":"Multiple courses of intralesional collagenase injections for Peyronie disease:a retrospective analysis","volume":"20","author":"Li","year":"2023","journal-title":"J Sex Med"},{"key":"R30-20250303","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.jsxm.2018.03.084","article-title":"Predictive factors of patients'and their partners'sexual function improvement after collagenase Clostridium histolyticum injection for Peyronie's disease:results from a multi-center single-arm study","volume":"15","author":"Cocci","year":"2018","journal-title":"J Sex Med"},{"key":"R31-20250303","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/bju.13096","article-title":"Clinical efficacy of collagenase Clostridium histolyticum in the treatment of Peyronie's disease by subgroup:results from two large, double-blind, randomized, placebo-controlled, phase III studies","volume":"116","author":"Lipshultz","year":"2015","journal-title":"BJU Int"},{"key":"R32-20250303","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.eururo.2007.07.013","article-title":"The natural history of Peyronie's disease:an ultrasonography-based study","volume":"53","author":"Bekos","year":"2008","journal-title":"Eur Urol"},{"key":"R33-20250303","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1111\/jsm.12334","article-title":"Peyronie's disease plaque calcification \u2013prevalence, time to identification, and development of a new grading classification","volume":"10","author":"Levine","year":"2013","journal-title":"J Sex Med"},{"key":"R34-20250303","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1111\/jsm.12275","article-title":"Extracorporeal shock wave therapy in Peyronie's disease:results of a placebo-controlled, prospective, randomized, single-blind study","volume":"10","author":"Hatzichristodoulou","year":"2013","journal-title":"J Sex Med"},{"key":"R35-20250303","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.urology.2005.11.005","article-title":"Effect of intralesional interferon-alpha 2b combined with oral vitamin E for treatment of early stage Peyronie's disease:a randomized and prospective study","volume":"67","author":"Inal","year":"2006","journal-title":"Urology"},{"key":"R36-20250303","doi-asserted-by":"crossref","first-page":"154","DOI":"10.4103\/UA.UA_65_17","article-title":"Prospective study to evaluate the clinical outcome of intralesional interferon-\u03b12b in the management of Peyronie's disease","volume":"10","author":"Sokhal","year":"2018","journal-title":"Urol Ann"},{"key":"R37-20250303","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/978-3-662-46753-4_2","article-title":"History and cultural perspective","author":"Kim","year":"2016","journal-title":"Penile Augmentation. Berlin:Springer Berlin Heidelberg"},{"key":"R38-20250303","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/s41585-021-00532-7","article-title":"Indications and characteristics of penile traction and vacuum erection devices","volume":"19","author":"Sultana","year":"2022","journal-title":"Nat Rev Urol"},{"key":"R39-20250303","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/JU.0000000000001052.01","article-title":"Re:penile traction therapy with the new device \u201cPenimaster PRO\u201dis effective and safe in the stable phase of Peyronie's disease:a controlled multicentre study","volume":"204","author":"Elliott","year":"2020","journal-title":"J Urol"},{"key":"R40-20250303","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/bju.14602","article-title":"Penile traction therapy with the new device \u201cPenimaster PRO\u201dis effective and safe in the stable phase of Peyronie's disease:a controlled multicentre study","volume":"123","author":"Moncada","year":"2019","journal-title":"BJU Int"},{"key":"R41-20250303","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.jsxm.2019.03.007","article-title":"Efficacy of combined collagenase Clostridium histolyticum and RestoreX penile traction therapy in men with Peyronie's disease","volume":"16","author":"Alom","year":"2019","journal-title":"J Sex Med"},{"key":"R42-20250303","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1016\/j.jsxm.2020.10.003","article-title":"Outcomes of RestoreX penile traction therapy in men with Peyronie's disease:results from open label and follow-up phases","volume":"17","author":"Joseph","year":"2020","journal-title":"J Sex Med"},{"key":"R43-20250303","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1007\/s00345-023-04533-6","article-title":"Low-intensity laser diode plus extracorporeal shock wave therapy:a new treatment strategy in the management of Peyronie's disease","volume":"41","author":"Dell'Atti","year":"2023","journal-title":"World J Urol"},{"key":"R44-20250303","first-page":"287","article-title":"Laser photobiomodulation of the induratio penis plastica or La Peyronie's syndrome","volume":"40","author":"Longo","year":"2022","journal-title":"Photobiomodul Photomed Laser Surg"},{"key":"R45-20250303","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.tibtech.2008.11.009","article-title":"Classification of platelet concentrates:from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF)","volume":"27","author":"Dohan Ehrenfest","year":"2009","journal-title":"Trends Biotechnol"},{"key":"R46-20250303","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/2090598X.2022.2135284","article-title":"Platelet-rich plasma in patients affected with Peyronie's disease","volume":"21","author":"Achraf","year":"2023","journal-title":"Arab J Urol"},{"key":"R47-20250303","doi-asserted-by":"crossref","first-page":"367","DOI":"10.23736\/S2724-6051.23.05458-7","article-title":"A new alternative approach to management of acute phase Peyronie's disease:low intensity extracorporeal shockwave therapy and platelet-rich plasma","volume":"76","author":"Karakose","year":"2024","journal-title":"Minerva Urol Nephrol"},{"key":"R48-20250303","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nrm2594","article-title":"Mechanotransduction at a distance:mechanically coupling the extracellular matrix with the nucleus","volume":"10","author":"Wang","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"R49-20250303","doi-asserted-by":"crossref","first-page":"339","DOI":"10.5534\/wjmh.180100","article-title":"Extracorporeal shock wave therapy in Peyronie's disease:clinical efficacy and safety from a single-arm observational study","volume":"37","author":"Di Mauro","year":"2019","journal-title":"World J Mens Health"},{"key":"R50-20250303","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41443-023-00673-w","article-title":"Long-term outcomes of extracorporeal shock wave therapy for acute Peyronie's disease:a 10-year retrospective analysis","volume":"36","author":"Spirito","year":"2024","journal-title":"Int J Impot Res"}],"container-title":["Asian Journal of Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aja202460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:26:28Z","timestamp":1786724788000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aja202460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,23]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/aja202460","relation":{},"ISSN":["1745-7262","1008-682X"],"issn-type":[{"value":"1745-7262","type":"print"},{"value":"1008-682X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,23]]},"assertion":[{"value":"2023-12-17","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-27","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}