{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:16:13Z","timestamp":1792682173825,"version":"4.5.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic toggle=\"yes\">Ureaplasma urealyticum<\/jats:italic>\n                    (UU) is one of the most commonly occurring pathogens associated with genital tract infections in infertile males, but the impact of seminal UU infection in semen on intrauterine insemination (IUI) outcomes is poorly understood. We collected data from 245 infertile couples who underwent IUI at The First Affiliated Hospital of USTC (Hefei, China) between January 2021 and January 2023. The subjects were classified into two groups according to their UU infection status: the UU-positive group and the UU-negative group. We compared semen parameters, pregnancy outcomes, and neonatal birth outcomes to investigate the impact of UU infection on IUI outcomes. There were no significantly statistical differences in various semen parameters, including semen volume, sperm concentration, total and progressive motility, sperm morphology, leukocyte count, the presence of anti-sperm antibody, and sperm DNA fragmentation index (DFI), between the UU-positive and UU-negative groups of male infertile patients (all\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &gt; 0.05). However, the high DNA stainability (HDS) status of sperm differed between the UU-positive and UU-negative groups, suggesting that seminal UU infection may affect sperm nuclear maturation (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.04). Additionally, there were no significant differences in pregnancy or neonatal birth outcomes between the two groups (all\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &gt; 0.05). These results suggest that IUI remains a viable and cost-effective option for infertile couples with UU infection who are facing infertility issues.\n                  <\/jats:p>","DOI":"10.4103\/aja202489","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T01:01:26Z","timestamp":1731027686000},"page":"219-224","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Associations of Ureaplasma urealyticum infection with male infertility and intrauterine insemination outcomes"],"prefix":"10.4103","volume":"27","author":[{"given":"Yang-Yang","family":"Wan","sequence":"first","affiliation":[{"name":"Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yun","family":"Shi","sequence":"additional","affiliation":[{"name":"Institute of Artificial Intelligence, Comprehensive National Science Center, Hefei 230001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Bai","sequence":"additional","affiliation":[{"name":"Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Yao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hua","family":"Jiang","sequence":"additional","affiliation":[{"name":"Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Min","family":"Wu","sequence":"additional","affiliation":[{"name":"Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Sheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"R1-20250303","doi-asserted-by":"crossref","first-page":"2328066","DOI":"10.1080\/14647273.2024.2328066","article-title":"A systematic review of interventions to improve male knowledge of fertility and fertility-related risk factors","volume":"27","author":"Krishnan","year":"2024","journal-title":"Hum Fertil (Camb)"},{"key":"R2-20250303","doi-asserted-by":"crossref","first-page":"17905","DOI":"10.1002\/jcp.28423","article-title":"Emerging role for Ureaplasma parvum serovar 3:active infection in women with silent high-risk human papillomavirus and in women with idiopathic infertility","volume":"234","author":"Zanotta","year":"2019","journal-title":"J Cell Physiol"},{"key":"R3-20250303","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/19396368.2024.2317804","article-title":"Insight into the complexity of male infertility:a multi-omics review","volume":"70","author":"Podgrajsek","year":"2024","journal-title":"Syst Biol Reprod Med"},{"key":"R4-20250303","doi-asserted-by":"crossref","first-page":"207","DOI":"10.5653\/cerm.2017.44.4.207","article-title":"Effects of infections with five sexually transmitted pathogens on sperm quality","volume":"44","author":"Kim","year":"2017","journal-title":"Clin Exp Reprod Med"},{"key":"R5-20250303","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12894-020-00742-y","article-title":"The effect of screening and treatment of Ureaplasma urealyticum infection on semen parameters in asymptomatic leukocytospermia:a case-control study","volume":"20","author":"Zhang","year":"2020","journal-title":"BMC Urol"},{"key":"R6-20250303","first-page":"2498306","article-title":"Risk prediction of Ureaplasma urealyticum affecting sperm quality based on mathematical model and cross-sectional study","volume":"2022","author":"Liu","year":"2022","journal-title":"Comput Math Methods Med"},{"key":"R7-20250303","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/andr.12886","article-title":"The semen microbiome and its impact on sperm function and male fertility:a systematic review and meta-analysis","volume":"9","author":"Farahani","year":"2021","journal-title":"Andrology"},{"key":"R8-20250303","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/s12879-021-06966-z","article-title":"Analysis of Ureaplasma urealyticum, Chlamydia trachomatis, Mycoplasma genitalium and Neisseria gonorrhoeae infections among obstetrics and gynecological outpatients in Southwest China:a retrospective study","volume":"22","author":"Liu","year":"2022","journal-title":"BMC Infect Dis"},{"key":"R9-20250303","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12958-021-00781-6","article-title":"Effect and mechanisms of reproductive tract infection on oxidative stress parameters, sperm DNA fragmentation, and semen quality in infertile males","volume":"19","author":"Liu","year":"2021","journal-title":"Reprod Biol Endocrinol"},{"key":"R10-20250303","doi-asserted-by":"crossref","first-page":"104183","DOI":"10.1016\/j.jri.2023.104183","article-title":"The effect of seminal 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infertility","volume":"24","author":"Bai","year":"2022","journal-title":"Asian J Androl"},{"key":"R14-20250303","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S0140-6736(17)33038-6","article-title":"Stimulated intrauterine insemination for unexplained subfertility","volume":"391","author":"Nandi","year":"2018","journal-title":"Lancet"},{"key":"R16-20250303","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/MOU.0000000000001081","article-title":"Evaluation and management of male genital tract infections in the setting of male infertility:an updated review","volume":"33","author":"Rivero","year":"2023","journal-title":"Curr Opin Urol"},{"key":"R17-20250303","doi-asserted-by":"crossref","first-page":"103635","DOI":"10.1016\/j.micpath.2019.103635","article-title":"Mycoplasma hominis profile in women:culture, kit, molecular diagnosis, antimicrobial resistance, and treatment","volume":"135","author":"Ozturk","year":"2019","journal-title":"Microb 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Rev"},{"key":"R21-20250303","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1007\/s00345-015-1724-z","article-title":"Ureaplasma urealyticum and Mycoplasma hominis infections and semen quality in 19,098 infertile men in China","volume":"34","author":"Huang","year":"2016","journal-title":"World J Urol"},{"key":"R22-20250303","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.jmii.2016.09.004","article-title":"Ureaplasma spp. in male infertility and its relationship with semen quality and seminal plasma components","volume":"51","author":"Zhou","year":"2018","journal-title":"J Microbiol Immunol Infect"},{"key":"R23-20250303","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1080\/19396368.2020.1801889","article-title":"Sperm content of TXNDC8 reflects sperm chromatin structure, pregnancy establishment, and incidence of multiple births after ART","volume":"66","author":"Ahlering","year":"2020","journal-title":"Syst Biol Reprod 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outcome","volume":"57","author":"Sun","year":"2018","journal-title":"Taiwan J Obstet Gynecol"}],"container-title":["Asian Journal of Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aja202489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:21:20Z","timestamp":1787836880000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aja202489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,8]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/aja202489","relation":{},"ISSN":["1745-7262","1008-682X"],"issn-type":[{"value":"1745-7262","type":"print"},{"value":"1008-682X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,8]]},"assertion":[{"value":"2024-03-26","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-12","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}