{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:23:21Z","timestamp":1792700601260,"version":"4.5.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The relationship between hyperuricemia (HUA) and erectile dysfunction (ED) remains inadequately understood. Given that HUA is often associated with various metabolic disorders, this study aims to explore the multivariate linear impacts of metabolic parameters on erectile function in ED patients with HUA. A cross-sectional analysis was conducted involving 514 ED patients with HUA in the Department of Andrology, Jiangsu Province Hospital of Chinese Medicine (Nanjing, China), aged 18 to 60 years. General demographic information, medical history, and laboratory results were collected to assess metabolic disturbances. Sexual function was evaluated using the 5-item version of the International Index of Erectile Function (IIEF-5) questionnaire. Based on univariate analysis, variables associated with IIEF-5 scores were identified, and the correlations between them were evaluated. The effects of these variables on IIEF-5 scores were further explored by multiple linear regression models. Fasting plasma glucose (\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    = \u22120.628,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001), uric acid (\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    = \u22120.552,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001), triglycerides (\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    = \u22120.088,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.047), low-density lipoprotein cholesterol (\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    = \u22120.164,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.027), glycated hemoglobin (HbA1c;\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    = \u22120.562,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.012), and smoking history (\n                    <jats:italic toggle=\"yes\">\u03b2<\/jats:italic>\n                    = \u22120.074,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.037) exhibited significant negative impacts on erectile function. The coefficient of determination (\n                    <jats:italic toggle=\"yes\">R<\/jats:italic>\n                    \u00b2) for the model was 0.239, and the adjusted\n                    <jats:italic toggle=\"yes\">R<\/jats:italic>\n                    \u00b2 was 0.230, indicating overall statistical significance (\n                    <jats:italic toggle=\"yes\">F<\/jats:italic>\n                    -statistic = 26.52,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001). Metabolic parameters play a crucial role in the development of ED. Maintaining normal metabolic indices may aid in the prevention and improvement of erectile function in ED patients with HUA.\n                  <\/jats:p>","DOI":"10.4103\/aja202516","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T04:01:27Z","timestamp":1747627287000},"page":"482-487","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Association between metabolic parameters and erection in erectile dysfunction patients with hyperuricemia"],"prefix":"10.4103","volume":"27","author":[{"given":"Guo-Wei","family":"Du","sequence":"first","affiliation":[{"name":"Department of Andrology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Ning","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Andrology, Siyang Traditional Chinese Medicine Hospital, Suqian 223700, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Xu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Andrology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Andrology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Chen","family":"He","sequence":"additional","affiliation":[{"name":"Department of Andrology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Andrology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Andrology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Huai","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Andrology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Andrology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"R1-20250716","first-page":"3167","article-title":"Update on the epidemiology, genetics, and therapeutic options of hyperuricemia","volume":"12","author":"Li","year":"2020","journal-title":"Am J Transl Res"},{"key":"R2-20250716","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1136\/annrheumdis-2022-eular.124","article-title":"AB1422 prevalence of hyperuricemia in Chinese adults:data from a cross-sectional study","volume":"81","author":"Zeng","year":"2022","journal-title":"Ann Rheum 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