{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T06:21:06Z","timestamp":1791699666226,"version":"4.3.4"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study aimed to investigate the associations between the post-wash total progressively motile sperm count (TPMSC) in the first intrauterine insemination (IUI) cycle and pregnancy outcomes of the second IUI cycle. Data were retrieved from the clinical database at the Reproductive Center of Peking University Third Hospital (Beijing, China) between January 2011 and December 2022. Couples were included in this retrospective cohort study if they had unexplained or mild male factor infertility and were treated with IUI for two consecutive cycles using the same protocol. A total of 8290 couples were included in the analysis. The mean \u00b1 standard deviation (s.d.) age of women was 32.0 \u00b1 3.5 years. We categorized groups based on the post-wash TPMSC (\u00d710\n                    <jats:sup>6<\/jats:sup>\n                    ) levels in the first IUI cycle: group 1 (0 &lt; TPMSC &lt; 1,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 1290), group 2 (1 \u2264 TPMSC &lt; 2,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 863), group 3 (2 \u2264 TPMSC &lt; 3,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 800), group 4 (3 \u2264 TPMSC &lt; 4,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 783), group 5 (4 \u2264 TPMSC &lt; 5,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 1541), group 6 (5 \u2264 TPMSC &lt; 6,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 522), group 7 (6 \u2264 TPMSC &lt; 7,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 547), group 8 (7 \u2264 TPMSC &lt; 8,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 175), group 9 (8 \u2264 TPMSC &lt; 9,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 556), group 10 (9 \u2264 TPMSC &lt; 10,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 192), and group 11 (TPMSC \u2265 10),\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 1021). The primary outcome was live birth rate of the second IUI cycle. Live birth rates were 7.9%, 5.8%, 7.6%, 7.4%, 7.3%, 8.4%, 7.5%, 7.4%, 8.8%, 8.9%, and 7.6% in each group, respectively. There were no statistically significant differences in clinical pregnancy rates or live birth rates between any groups and those with the post-wash TPMSC &lt;1 \u00d7 10\n                    <jats:sup>6<\/jats:sup>\n                    . In an IUI program for unexplained and mild male factor infertility, the post-wash TPMSC in the first IUI cycle was not significantly associated with the live birth rate in the second IUI cycle.\n                  <\/jats:p>","DOI":"10.4103\/aja202524","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T08:00:54Z","timestamp":1749801654000},"page":"757-762","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Should couples with a low total progressively motile sperm count in the first intrauterine insemination cycle continue this treatment?"],"prefix":"10.4103","volume":"27","author":[{"given":"Zheng","family":"Wang","sequence":"first","affiliation":[{"name":"Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China"},{"name":"State Key Laboratory of Female Fertility Promotion, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China"},{"name":"Key Laboratory of Assisted Reproduction, Peking University, Ministry of Education, Beijing 100871, China"},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Peking University Third Hospital, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China"},{"name":"State Key Laboratory of Female Fertility Promotion, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China"},{"name":"Key Laboratory of Assisted Reproduction, Peking University, Ministry of Education, Beijing 100871, China"},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Peking University Third Hospital, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Huang","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China"},{"name":"State Key Laboratory of Female Fertility Promotion, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China"},{"name":"Key Laboratory of Assisted Reproduction, Peking University, Ministry of Education, Beijing 100871, China"},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Peking University Third Hospital, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China"},{"name":"State Key Laboratory of Female Fertility Promotion, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China"},{"name":"Key Laboratory of Assisted Reproduction, Peking University, Ministry of Education, Beijing 100871, China"},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Peking University Third Hospital, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China"},{"name":"State Key Laboratory of Female Fertility Promotion, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China"},{"name":"Key Laboratory of Assisted Reproduction, Peking University, Ministry of Education, Beijing 100871, China"},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Peking University Third Hospital, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben Willem","family":"Mol","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Monash University, Clayton, VIC 3800, Australia"},{"name":"School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen AB24 3FX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Qiao","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China"},{"name":"State Key Laboratory of Female Fertility Promotion, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China"},{"name":"Key Laboratory of Assisted Reproduction, Peking University, Ministry of Education, Beijing 100871, China"},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Peking University Third Hospital, Beijing 100191, 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retrospective study","volume":"14","author":"Ok","year":"2013","journal-title":"J Turk Ger Gynecol Assoc"},{"key":"R7-20251103","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1007\/s10815-014-0306-0","article-title":"Predictive value of postwashed total progressively motile sperm count using CASA estimates in 6871 non-donor intrauterine insemination cycles","volume":"31","author":"Tan","year":"2014","journal-title":"J Assist Reprod Genet"},{"key":"R8-20251103","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1080\/09513590.2022.2126453","article-title":"The relationship of total progressive motile sperm count with the outcome of IUI?An analysis of 5171 cycles","volume":"38","author":"Lin","year":"2022","journal-title":"Gynecol Endocrinol"},{"key":"R9-20251103","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.fertnstert.2016.02.012","article-title":"Predictive value of sperm morphology and progressively motile sperm count for pregnancy outcomes in 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