{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:03:39Z","timestamp":1793142219291,"version":"4.5.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Despite surgical advancements, erectile dysfunction (ED) is a common consequence of radical prostatectomy (RP). This study aimed to evaluate the impact of early penile rehabilitation within a dedicated penile rehabilitation program on assisted and unassisted erectile function (EF) recovery. All patients who underwent RP and at least 1 year follow-up at penile rehabilitation program in the Department of Urology, OORR Policlinico Riuniti (Foggia, Italy) were included. Treatment involved phosphodiesterase type 5 inhibitors (PDE5Is; tadalafil 20 mg, 1 tablet every other day), intracavernous injections (Caverject 5 \u00b5g, 1 vial per week), and daily use of vacuum erection devices (VEDs). Primary end point was EF recovery defined as International Index of Erectile Function-5 (IIEF-5) \u226521 with or without rehabilitation aids. IIEF-5 and prescribed treatments were prospectively collected at 3 months, 6 months, 9 months, 12 months, and 24 months. Among 570 eligible patients, 397 (69.6%) underwent rehabilitation. Patients who undergoing andro-rehabilitation were younger (65 months vs 70 months;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.0001), had lower prostate-specific antigen (PSA) levels (5.9 ng ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    vs 6.2 ng ml\n                    <jats:sup>\u22121<\/jats:sup>\n                    ;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.04), and lower grade tumors (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.001) compared to the patients who did not undergo sexual rehabilitation after radical prostatectomy. Two-year EF recovery rates in patients undergoing andro-rehabilitation ranged from 75% (preoperative IIEF-5 &gt;16) to 45% (preoperative IIEF-5 &lt;16) with rehabilitation aids. Combination treatments (PDE5I+VEDs with or without intracavernous injections) showed the highest rates of EF recovery (up to 80% at 2 years). EF recovery without rehabilitation aids was significantly higher for patients with IIEF-5 &gt;21 (IIEF-5 &gt;21 [36%] vs IIEF-5 of 17\u201321 [18%];\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.01). Subanalysis indicated a moderate benefit of rehabilitation in patients with preoperative IIEF-5 &lt;16 who underwent bilateral nerve-sparing RP. Participation in intensive penile rehabilitation programs improves EF recovery in patients undergoing RP. Preserving the neurovascular bundles may be beneficial for patients with preoperative ED.\n                  <\/jats:p>","DOI":"10.4103\/aja202525","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T04:02:16Z","timestamp":1747627336000},"page":"680-685","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Sexual function recovery following open and robotic radical prostatectomy: results of an academic penile rehabilitation program"],"prefix":"10.4103","volume":"27","author":[{"given":"Michele Di","family":"Nauta","sequence":"first","affiliation":[{"name":"Andrology Unit, Department of Urology and Kidney Transplantation, University of Foggia, Foggia 71122, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugo Giovanni","family":"Falagario","sequence":"additional","affiliation":[{"name":"Andrology Unit, Department of Urology and Kidney Transplantation, University of Foggia, Foggia 71122, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Ricapito","sequence":"additional","affiliation":[{"name":"Andrology Unit, Department of Urology and Kidney Transplantation, University of Foggia, Foggia 71122, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Rubino","sequence":"additional","affiliation":[{"name":"Andrology Unit, Department of Urology and Kidney Transplantation, University of Foggia, Foggia 71122, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Annese","sequence":"additional","affiliation":[{"name":"Andrology Unit, Department of Urology and Kidney Transplantation, University of Foggia, Foggia 71122, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Maria","family":"Busetto","sequence":"additional","affiliation":[{"name":"Andrology Unit, Department of Urology and Kidney Transplantation, University of Foggia, Foggia 71122, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Cormio","sequence":"additional","affiliation":[{"name":"Department of Urology, Bonomo Teaching Hospital, University of Foggia, Andria (BAT) 76123, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Carrieri","sequence":"additional","affiliation":[{"name":"Andrology Unit, Department of Urology and Kidney Transplantation, University of Foggia, Foggia 71122, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Bettocchi","sequence":"additional","affiliation":[{"name":"Andrology Unit, Department of Urology and Kidney Transplantation, University of Foggia, Foggia 71122, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"R2-20251103","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1056\/NEJMoa074311","article-title":"Quality of life and satisfaction with outcome among prostate-cancer survivors","volume":"358","author":"Sanda","year":"2008","journal-title":"N Engl J Med"},{"key":"R3-20251103","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/bju.13030","article-title":"Effect of surgical approach on erectile function recovery following bilateral nerve-sparing radical prostatectomy:an evaluation utilising data from a randomised, double-blind, double-dummy multicentre trial of tadalafil versus placebo","volume":"116","author":"Stolzenburg","year":"2015","journal-title":"BJU Int"},{"key":"R4-20251103","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.eururo.2012.05.046","article-title":"Systematic review and meta-analysis of studies reporting potency rates after robot-assisted radical prostatectomy","volume":"62","author":"Ficarra","year":"2012","journal-title":"Eur Urol"},{"key":"R5-20251103","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S0140-6736(16)30592-X","article-title":"Robot-assisted laparoscopic prostatectomy versus open radical retropubic prostatectomy:early outcomes from a randomised controlled phase 3 study","volume":"388","author":"Yaxley","year":"2016","journal-title":"Lancet"},{"key":"R6-20251103","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/smrj.21","article-title":"Erectile function outcomes after robot-assisted radical prostatectomy:is it superior to open retropubic or laparoscopic approach?","volume":"2","author":"Isgoren","year":"2014","journal-title":"Sex Med Rev"},{"key":"R7-20251103","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jsxm.2016.11.324","article-title":"Sexual rehabilitation after treatment for prostate cancer-part 2:recommendations from the fourth International Consultation for Sexual Medicine (ICSM 2015).","volume":"14","author":"Salonia","year":"2017","journal-title":"J Sex Med"},{"key":"R8-20251103","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.eururo.2012.04.046","article-title":"Prevention and management of postprostatectomy sexual dysfunctions part 1:choosing the right patient at the right time for the right surgery","volume":"62","author":"Salonia","year":"2012","journal-title":"Eur Urol"},{"key":"R9-20251103","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.eururo.2021.06.007","article-title":"European Association of Urology guidelines on sexual and reproductive health-2021 update:male sexual dysfunction","volume":"80","author":"Salonia","year":"2021","journal-title":"Eur Urol"},{"key":"R10-20251103","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jsxm.2016.01.005","article-title":"Recovery of baseline erectile function in men following radical prostatectomy for high-risk prostate cancer:a prospective analysis using validated measures","volume":"13","author":"Sridhar","year":"2016","journal-title":"J Sex Med"},{"key":"R11-20251103","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0094-0143(05)70142-7","article-title":"Vacuum constriction and external erection devices in erectile dysfunction","volume":"28","author":"Levine","year":"2001","journal-title":"Urol Clin North Am"},{"key":"R12-20251103","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/ijir.2010.4","article-title":"Vacuum therapy in erectile dysfunction \u2013science and clinical evidence","volume":"22","author":"Yuan","year":"2010","journal-title":"Int J Impot Res"},{"key":"R13-20251103","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ebiom.2016.01.024","article-title":"Safety and potential effect of a single intracavernous injection of autologous adipose-derived regenerative cells in patients with erectile dysfunction following radical prostatectomy:an open-label phase I clinical trial","volume":"5","author":"Haahr","year":"2016","journal-title":"EBioMedicine"},{"key":"R14-20251103","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/sj.ijir.3900472","article-title":"Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction","volume":"11","author":"Rosen","year":"1999","journal-title":"Int J Impot Res"},{"key":"R15-20251103","first-page":"197","article-title":"Critical points in understanding the Italian version of the IIEF 5 questionnaire","volume":"84","author":"D'Elia","year":"2012","journal-title":"Arch Ital Urol Androl"},{"key":"R16-20251103","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/SPC.0000000000000195","article-title":"Erectile dysfunction after radical prostatectomy:prevalence, medical treatments, and psychosocial interventions","volume":"10","author":"Emanu","year":"2016","journal-title":"Curr Opin Support Palliat Care"},{"key":"R17-20251103","doi-asserted-by":"crossref","first-page":"2","DOI":"10.21037\/tau.2016.08.14","article-title":"The controversy surrounding penile rehabilitation after radical prostatectomy","volume":"6","author":"Clavell-Hern\u00e1ndez","year":"2017","journal-title":"Transl Androl Urol"},{"key":"R18-20251103","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1097\/JU.0000000000001584","article-title":"Penile rehabilitation strategy after nerve sparing radical prostatectomy:a systematic review and network meta-analysis of randomized trials","volume":"205","author":"Sari","year":"2021","journal-title":"J Urol"},{"key":"R19-20251103","doi-asserted-by":"crossref","first-page":"112","DOI":"10.4111\/kju.2014.55.2.112","article-title":"The efficacy and safety of tadalafil 5 mg once daily in the treatment of erectile dysfunction after robot-assisted laparoscopic radical prostatectomy:1-year follow-up","volume":"55","author":"Seo","year":"2014","journal-title":"Korean J Urol"},{"key":"R20-20251103","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.esxm.2017.12.005","article-title":"Efficacy and safety of tadalafil 5 mg once daily for the treatment of erectile dysfunction after robot-assisted laparoscopic radical prostatectomy:a 2-year follow-up","volume":"6","author":"Kim","year":"2018","journal-title":"Sex Med"},{"key":"R21-20251103","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.eururo.2013.09.051","article-title":"Effects of tadalafil treatment on erectile function recovery following bilateral nerve-sparing radical prostatectomy:a randomised placebo-controlled study (REACTT)","volume":"65","author":"Montorsi","year":"2014","journal-title":"Eur Urol"},{"key":"R22-20251103","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1177\/1557988318797409","article-title":"The early use of vacuum therapy for penile 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History"}},{"value":"2025-03-17","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}