{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:22:04Z","timestamp":1787775724616,"version":"build-2784847793"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This review focuses on the diagnostic algorithm for nonobstructive azoospermia (NOA), a significant male factor contributing to infertility. NOA, characterized by the absence of sperm in the ejaculate, requires a systematic diagnostic approach to identify reversible conditions, genetic factors, and prognosis for achieving pregnancy. The diagnostic pathway involves semen analysis and a comprehensive evaluation for hormonal deficiencies, anatomical abnormalities, and genetic factors. The importance of medical history, physical examination, endocrine evaluation, imaging, and genetic testing is emphasized. This review highlights the significance of differentiating NOA from obstructive azoospermia (OA) and outlines key considerations for effective management, including surgical sperm retrieval and assisted reproductive techniques. Testicular biopsy is discussed as a definitive method to distinguish obstructive cases from nonobstructive cases, providing valuable prognostic information. Overall, a thorough and systematic diagnostic approach is essential for the effective management of men suspected with NOA, offering insights into potential treatment options and reproductive outcomes.<\/jats:p>","DOI":"10.4103\/aja202529","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T02:00:14Z","timestamp":1745546414000},"page":"307-310","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Diagnostic algorithm in men suspected with nonobstructive azoospermia"],"prefix":"10.4103","volume":"27","author":[{"given":"Mahdi","family":"Bazzi","sequence":"first","affiliation":[{"name":"Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI 48202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Chabot","sequence":"additional","affiliation":[{"name":"Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI 48202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amarnath","family":"Rambhatla","sequence":"additional","affiliation":[{"name":"Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI 48202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Chung","sequence":"additional","affiliation":[{"name":"The University of Queensland, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"R2-20250512","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/oxfordjournals.humrep.a137433","article-title":"Incedence and main causes of infertility in a resident population (1,850,000) of three French regions (1988-1989)","volume":"6","author":"Thonneau","year":"1991","journal-title":"Hum Reprod"},{"key":"R3-20250512","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0022-5347(17)38662-7","article-title":"Evaluation of the azoospermic patient","volume":"142","author":"Jarow","year":"1989","journal-title":"J Urol"},{"key":"R4-20250512","first-page":"27","article-title":"Azoospermia: incidence, and biochemical evaluation of seminal plasma by the differential pH method","volume":"42","author":"Mazzilli","year":"2000","journal-title":"Panminerva Med"},{"key":"R5-20250512","first-page":"S210","article-title":"Male Infertility Best Practice Policy Committee of the American Urological Association, Practice Committee of the American Society for Reproductive Medicine. 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