{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:39:20Z","timestamp":1786653560621,"version":"build-2736575974"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>\n                    In this study, we aimed to investigate the influence of paternal oligozoospermia (OZ), asthenozoospermia (AZ), or teratozoospermia (TZ) on blastocyst ploidy and its potential interaction with maternal age. We analyzed 3383 embryos in 1091 preimplantation genetic testing for aneuploidy (PGT-A) cycles via next-generation sequencing (NGS) at the Center for Reproductive Medicine, Shandong University (Jinan, China). Our findings revealed that compared to the normozoospermic (NZ) group, the AZ group exhibited significantly lower euploidy rates (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.022). This effect was more pronounced in cases with advanced maternal age (AMA; \u226538 years), where AZ patients had markedly reduced euploidy rates (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = 0.003), while no significant differences were observed in younger women (&lt;38 years). Multivariate analysis, adjusting for parental age and body mass index (BMI), confirmed that AZ is an independent risk factor for reduced euploidy rates in the AMA subgroup. Notably, OZ and TZ cases showed no significant association with blastocyst ploidy rates. These results suggest that only in cases of advanced maternal age, impaired sperm motility adversely affect blastocyst euploidy rates.\n                  <\/jats:p>","DOI":"10.4103\/aja202560","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T11:00:10Z","timestamp":1768302010000},"page":"246-251","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Impact of semen quality and maternal age on blastocyst chromosomal abnormalities: a retrospective cohort study based on 1091 PGT-A cycles"],"prefix":"10.4103","volume":"28","author":[{"given":"Yang","family":"Zou","sequence":"first","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan 250012, China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan 250012, China"},{"name":"Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan 250012, China"},{"name":"Shandong Technology Innovation Center for Reproductive Health, Jinan 250012, China"},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health, Jinan 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xu","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510220, China"},{"name":"Guangdong-Hong Kong Metabolism and Reproduction Joint Laboratory, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510220, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Qiang","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of 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250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan 250012, China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan 250012, China"},{"name":"Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan 250012, China"},{"name":"Shandong Technology Innovation Center for Reproductive Health, Jinan 250012, China"},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health, Jinan 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Jing","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510220, China"},{"name":"Guangdong-Hong Kong Metabolism and Reproduction Joint Laboratory, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou 510220, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan 250012, China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan 250012, China"},{"name":"Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan 250012, China"},{"name":"Shandong Technology Innovation Center for Reproductive Health, Jinan 250012, China"},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health, Jinan 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Hao","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan 250012, China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan 250012, China"},{"name":"Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan 250012, China"},{"name":"Shandong Technology Innovation Center for Reproductive Health, Jinan 250012, China"},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health, Jinan 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Jiang","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of 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