{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T13:39:26Z","timestamp":1793281166483,"version":"4.5.0"},"reference-count":89,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:p>With global population aging, erectile dysfunction is becoming increasingly prevalent among middle-aged and older men, who frequently present with cardiometabolic comorbidities, such as hypertension and diabetes mellitus. Although these conditions are well-established risk factors for erectile dysfunction, their long-term pharmacological management may exert heterogeneous and adverse effects on erectile function, complicating clinical decision-making. This review synthesizes current evidence on the shared pathophysiological mechanisms linking erectile dysfunction with hypertension and diabetes mellitus, including endothelial dysfunction, oxidative stress, vascular remodeling, metabolic dysregulation, and neurovascular impairment. This review also critically evaluates the effects of commonly prescribed antihypertensive and antidiabetic drug classes on erectile function, highlighting both their beneficial and detrimental profiles. By integrating mechanistic insights with clinical evidence, this review highlights medication-associated sexual dysfunction in aging men. It emphasizes its recognition and management in clinical practice. The goal is to guide individualized treatment strategies that control cardiometabolic disease while preserving sexual health and quality of life.<\/jats:p>","DOI":"10.4103\/aja202621","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:04:16Z","timestamp":1785506656000},"page":"728-735","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Erectile dysfunction in aging men: evidence and insights related to antihypertensive and antidiabetic medications"],"prefix":"10.4103","volume":"28","author":[{"given":"Zhan-Peng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiting","family":"Lin","sequence":"additional","affiliation":[{"name":"Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA 94134, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Hu","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210000, China"},{"name":"Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA 94134, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7,31]]},"reference":[{"key":"R1-20261029","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1097\/JU.0000000000001367","article-title":"Erectile dysfunction in a sample of sexually active young adult men from a U.S. cohort: demographic, metabolic and mental health correlates","volume":"205","author":"Calzo","year":"2021","journal-title":"J Urol"},{"key":"R2-20261029","doi-asserted-by":"crossref","first-page":"14249","DOI":"10.4081\/aiua.2025.14249","article-title":"Prevalence of erectile dysfunction and relationship between high sensitivity C-reactive protein, albuminuria, and cardiovascular risk factors with erectile dysfunction in coronary artery disease patients","volume":"97","author":"Daryanto","year":"2025","journal-title":"Arch Ital Urol Androl"},{"key":"R3-20261029","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2147\/VHRM.S223331","article-title":"Understanding erectile dysfunction in hypertensive patients: the need for good patient management","volume":"16","author":"Hernandez-Cerda","year":"2020","journal-title":"Vasc Health Risk Manag"},{"key":"R4-20261029","doi-asserted-by":"crossref","first-page":"28816","DOI":"10.1038\/s41598-024-78182-z","article-title":"Exploring the bidirectional link between erectile dysfunction and 10-year cardiovascular risk in men with diabetes and hypertension","volume":"14","author":"Dang","year":"2024","journal-title":"Sci Rep"},{"key":"R5-20261029","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1097\/HJH.0000000000002382","article-title":"Update of the position paper on arterial hypertension and erectile dysfunction","volume":"38","author":"Viigimaa","year":"2020","journal-title":"J Hypertens"},{"key":"R6-20261029","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.dsx.2020.04.039","article-title":"Association of erectile dysfunction and type II diabetes mellitus at a tertiary care centre of South India","volume":"14","author":"Nutalapati","year":"2020","journal-title":"Diabetes Metab Syndr"},{"key":"R7-20261029","first-page":"e30998","article-title":"Prevalence and the associated factors of erectile dysfunction among Saudi married males","volume":"14","author":"Alenezi","year":"2022","journal-title":"Cureus"},{"key":"R8-20261029","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1097\/JCMA.0000000000000691","article-title":"Diabetes associated with hypertension exacerbated oxidative stress-mediated inflammation, apoptosis and autophagy leading to erectile dysfunction in rats","volume":"85","author":"Yang","year":"2022","journal-title":"J Chin Med Assoc"},{"key":"R9-20261029","doi-asserted-by":"crossref","first-page":"20","DOI":"10.51866\/cr.282","article-title":"Erectile dysfunction as a possible important side effect of metformin: a case report","volume":"18","author":"Ngu","year":"2023","journal-title":"Malays Fam Physician"},{"key":"R10-20261029","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s12958-025-01425-9","article-title":"Short-term impact of tirzepatide on metabolic hypogonadism and body composition in patients with obesity: a controlled pilot study","volume":"23","author":"La Vignera","year":"2025","journal-title":"Reprod Biol Endocrinol"},{"key":"R11-20261029","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/andr.13257","article-title":"The management of erectile dysfunction in men with diabetes mellitus unresponsive to phosphodiesterase type 5 inhibitors","volume":"11","author":"Cayetano-Alcaraz","year":"2023","journal-title":"Andrology"},{"key":"R12-20261029","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.amjmed.2020.05.039","article-title":"The effect of calcium channel blockers on moderate or severe albuminuria in diabetic, hypertensive patients","volume":"134","author":"Cativo","year":"2021","journal-title":"Am J Med"},{"key":"R13-20261029","doi-asserted-by":"crossref","first-page":"691","DOI":"10.2147\/VHRM.S439334","article-title":"Relationship between hypertension, antihypertensive drugs and sexual dysfunction in men and women: a literature review","volume":"19","author":"Lou","year":"2023","journal-title":"Vasc Health Risk Manag"},{"key":"R14-20261029","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1161\/HYPERTENSIONAHA.122.19020","article-title":"Individualized beta-blocker treatment for high blood pressure dictated by medical comorbidities: indications beyond the 2018 European Society of Cardiology\/European Society of Hypertension guidelines","volume":"79","author":"Mancia","year":"2022","journal-title":"Hypertension"},{"key":"R15-20261029","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s11906-012-0276-5","article-title":"Antihypertensive treatment and sexual dysfunction","volume":"14","author":"Manolis","year":"2012","journal-title":"Curr Hypertens Rep"},{"key":"R16-20261029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejim.2020.07.009","article-title":"Erectile dysfunction and adherence to antihypertensive therapy: focus on beta-blockers","volume":"81","author":"Manolis","year":"2020","journal-title":"Eur J Intern Med"},{"key":"R17-20261029","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1161\/HYPERTENSIONAHA.124.24013","article-title":"Time in target range for blood pressure and adverse health outcomes: a systematic review","volume":"82","author":"Wang","year":"2025","journal-title":"Hypertension"},{"key":"R18-20261029","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1080\/08037051.2020.1856642","article-title":"Cardiovascular outcomes at recommended blood pressure targets in middle-aged and elderly patients with type 2 diabetes mellitus compared to all middle-aged and elderly hypertensive study patients with high cardiovascular risk","volume":"30","author":"Olsen","year":"2021","journal-title":"Blood Press"},{"key":"R19-20261029","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1080\/08037051.2020.1855968","article-title":"Cardiovascular outcomes at recommended blood pressure targets in middle-aged and elderly patients with type 2 diabetes mellitus and hypertension","volume":"30","author":"Olsen","year":"2021","journal-title":"Blood Press"},{"key":"R20-20261029","doi-asserted-by":"crossref","first-page":"7833","DOI":"10.3390\/ijms21217833","article-title":"Molecular mechanisms of SGLT2 inhibitor on cardiorenal protection","volume":"21","author":"Hou","year":"2020","journal-title":"Int J Mol Sci"},{"key":"R21-20261029","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s11906-023-01281-1","article-title":"Blood pressure effects of SGLT2 inhibitors: mechanisms and clinical evidence in different populations","volume":"25","author":"Beal","year":"2023","journal-title":"Curr Hypertens Rep"},{"key":"R22-20261029","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13098-023-01092-z","article-title":"Efficacy and safety evaluation of SGLT2i on blood pressure control in patients with type 2 diabetes and hypertension: a new meta-analysis","volume":"15","author":"Zhang","year":"2023","journal-title":"Diabetol Metab Syndr"},{"key":"R23-20261029","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1177\/1357633X241298169","article-title":"The effect of telehealth on clinical outcomes in patients with hypertension and diabetes: a meta-analysis of 106,261 patients","volume":"31","author":"Kelly","year":"2025","journal-title":"J Telemed Telecare"},{"key":"R24-20261029","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1186\/s12889-025-22204-6","article-title":"Efficacy of short message service (SMS) intervention on medication adherence and knowledge of stroke prevention among clinic attendees at risk of stroke: a randomized controlled trial","volume":"25","author":"Aigbonoga","year":"2025","journal-title":"BMC Public Health"},{"key":"R25-20261029","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s41569-021-00593-6","article-title":"Interactions between erectile dysfunction, cardiovascular disease and cardiovascular drugs","volume":"19","author":"Terentes-Printzios","year":"2022","journal-title":"Nat Rev Cardiol"},{"key":"R26-20261029","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1007\/s10557-021-07197-9","article-title":"Effects of major antihypertensive drug classes on erectile function: a network meta-analysis","volume":"36","author":"Farmakis","year":"2022","journal-title":"Cardiovasc Drugs Ther"},{"key":"R27-20261029","first-page":"1613","article-title":"[Erectile dysfunction in the hypertensive patient]","volume":"20","author":"Vella","year":"2024","journal-title":"Rev Med Suisse"},{"key":"R28-20261029","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.hjc.2024.09.007","article-title":"The impact of cardiovascular drugs on hyperglycemia and diabetes: a review of 'unspoken' side effects","volume":"83","author":"Widiarti","year":"2025","journal-title":"Hellenic J Cardiol"},{"key":"R29-20261029","first-page":"e93259","article-title":"The impact of commonly used medications on erectile dysfunction: which drugs deserve particular attention?","volume":"17","author":"Czyzewski","year":"2025","journal-title":"Cureus"},{"key":"R30-20261029","doi-asserted-by":"crossref","first-page":"1157467","DOI":"10.3389\/fcvm.2023.1157467","article-title":"Genetically predicted hypertension, antihypertensive drugs, and risk of erectile dysfunction: a Mendelian randomization study","volume":"10","author":"Zhao","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"R31-20261029","doi-asserted-by":"crossref","first-page":"6315","DOI":"10.3390\/cimb46070377","article-title":"The evolving role of calcium channel blockers in hypertension management: pharmacological and clinical considerations","volume":"46","author":"Jones","year":"2024","journal-title":"Curr Issues Mol Biol"},{"key":"R32-20261029","doi-asserted-by":"crossref","first-page":"40","DOI":"10.2174\/1871525721666230224111518","article-title":"A comprehensive insight on pharmacological properties of cilnidipine: a fourth-generation calcium channel blocker","volume":"22","author":"Kadian","year":"2023","journal-title":"Cardiovasc Hematol Agents Med Chem"},{"key":"R33-20261029","doi-asserted-by":"crossref","first-page":"88","DOI":"10.59556\/japi.71.0400","article-title":"The promise of cilnidipine in hypertension with comorbidities: national consensus statement: national consensus group comprises cardiologists, nephrologists, and diabetologists from India in a national meet at New Delhi held on 22nd May 2022","volume":"72","author":"Chopra","year":"2024","journal-title":"J Assoc Physicians India"},{"key":"R34-20261029","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/HJH.0000000000004156","article-title":"Optimizing blood pressure control in multimorbid hypertensive patients: insights from a real-world taiwanese cohort","volume":"44","author":"Sum","year":"2026","journal-title":"J Hypertens"},{"key":"R35-20261029","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s11906-023-01248-2","article-title":"Ace-inhibitors in hypertension: a historical perspective and current insights","volume":"25","author":"Cutrell","year":"2023","journal-title":"Curr Hypertens Rep"},{"key":"R36-20261029","doi-asserted-by":"crossref","first-page":"1557988319892735","DOI":"10.1177\/1557988319892735","article-title":"Angiotensin receptor blockers for erectile dysfunction in hypertensive men: a brief meta-analysis of randomized control trials","volume":"13","author":"Ismail","year":"2019","journal-title":"Am J Mens Health"},{"key":"R37-20261029","doi-asserted-by":"crossref","first-page":"9227","DOI":"10.1038\/s41598-026-40790-2","article-title":"Sexual function among controlled and uncontrolled hypertensive females receiving beta-blockers or ACEI\/ARB and thiazides: a prospective randomized controlled study","volume":"16","author":"GamalEl Din","year":"2026","journal-title":"Sci Rep"},{"key":"R38-20261029","first-page":"CD006687","article-title":"Vasodilators for primary Raynaud's phenomenon","volume":"5","author":"Su","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"R39-20261029","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2174\/1574886317666220405121319","article-title":"Coronavirus disease 2019 and hypertension: how anti-hypertensive drugs affect COVID-19 medications and vice versa","volume":"18","author":"Doostkam","year":"2023","journal-title":"Curr Drug Saf"},{"key":"R40-20261029","doi-asserted-by":"crossref","first-page":"138","DOI":"10.2174\/1573402118666220627120254","article-title":"Target blood pressure and combination therapy: focus on angiotensin receptor blockers combination with either calcium channel blockers or beta blockers","volume":"18","author":"Farag","year":"2022","journal-title":"Curr Hypertens Rev"},{"key":"R41-20261029","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s12886-022-02397-9","article-title":"Effects of intensive insulin therapy on the retinal microvasculature in patients with type 2 diabetes mellitus: a prospective observational study","volume":"22","author":"Yang","year":"2022","journal-title":"BMC Ophthalmol"},{"key":"R42-20261029","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/s12902-024-01782-3","article-title":"Time to development of macrovascular complications and its predictors among type 2 diabetes mellitus patients at Jimma University Medical Center","volume":"24","author":"Adare","year":"2024","journal-title":"BMC Endocr Disord"},{"key":"R43-20261029","doi-asserted-by":"crossref","first-page":"1485357","DOI":"10.3389\/fmed.2025.1485357","article-title":"Re-starting or initiating guideline-recommended hypoglycemic agents for patients admitted with hyperglycemic crisis","volume":"12","author":"Alshaya","year":"2025","journal-title":"Front Med (Lausanne)"},{"key":"R44-20261029","first-page":"e90196","article-title":"Effectiveness of insulin versus oral agents in patients with uncontrolled type 2 diabetes mellitus: a retrospective comparative study","volume":"17","author":"Naeem","year":"2025","journal-title":"Cureus"},{"key":"R45-20261029","first-page":"e87223","article-title":"The impact of semaglutide on metabolic syndrome: a case report","volume":"17","author":"Joseph","year":"2025","journal-title":"Cureus"},{"key":"R46-20261029","doi-asserted-by":"crossref","first-page":"23108","DOI":"10.1038\/s41598-025-95439-3","article-title":"Exploring possible hub genes of metabolic syndrome and type 2 diabetes mellitus: a systematic network biology study","volume":"15","author":"Runthala","year":"2025","journal-title":"Sci Rep"},{"key":"R47-20261029","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40780-020-00169-5","article-title":"Impact of sitagliptin combination therapy and hypoglycemia in Japanese patients with type 2 diabetes: a multi-center retrospective observational cohort study","volume":"6","author":"Saito","year":"2020","journal-title":"J Pharm Health Care Sci"},{"key":"R48-20261029","doi-asserted-by":"crossref","first-page":"120543","DOI":"10.1016\/j.lfs.2022.120543","article-title":"Characteristics and molecular mechanisms through which SGLT2 inhibitors improve metabolic diseases: a mechanism review","volume":"300","author":"Xie","year":"2022","journal-title":"Life Sci"},{"key":"R49-20261029","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1007\/s40262-023-01301-y","article-title":"Imeglimin: a clinical pharmacology review","volume":"62","author":"Chevalier","year":"2023","journal-title":"Clin Pharmacokinet"},{"key":"R50-20261029","doi-asserted-by":"crossref","first-page":"6802","DOI":"10.1097\/MS9.0000000000003750","article-title":"Sglt2i-induced euglycemic diabetic ketoacidosis in a heart failure patient with acute myocardial infarction: a case report","volume":"87","author":"Huang","year":"2025","journal-title":"Ann Med Surg (Lond)"},{"key":"R51-20261029","doi-asserted-by":"crossref","first-page":"e373","DOI":"10.5001\/omj.2022.17","article-title":"Severe prolonged SGLt2i-induced euglycemic diabetic ketoacidosis refractory to standard therapy and dialysis: case report and literature review","volume":"37","author":"Almazrouei","year":"2022","journal-title":"Oman Med J"},{"key":"R52-20261029","doi-asserted-by":"crossref","first-page":"467","DOI":"10.2147\/DMSO.S503216","article-title":"Effects of anti-diabetic drugs on erectile dysfunction: a systematic review and meta-analysis","volume":"18","author":"Yang","year":"2025","journal-title":"Diabetes Metab Syndr Obes"},{"key":"R53-20261029","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/andr.13519","article-title":"Long-acting glucagon-like peptide 1 receptor agonists boost erectile function in men with type 2 diabetes mellitus complaining of erectile dysfunction: a retrospective cohort study","volume":"12","author":"Lisco","year":"2024","journal-title":"Andrology"},{"key":"R54-20261029","doi-asserted-by":"crossref","first-page":"355","DOI":"10.21037\/tau.2020.02.07","article-title":"Effect of icariside II and metformin on penile erectile function, glucose metabolism, reaction oxygen species, superoxide dismutase, and mitochondrial autophagy in type 2 diabetic rats with erectile dysfunction","volume":"9","author":"Zhang","year":"2020","journal-title":"Transl Androl Urol"},{"key":"R55-20261029","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.esxm.2020.01.006","article-title":"Effect of icariside II and metformin on penile erectile function, histological structure, mitochondrial autophagy, glucose-lipid metabolism, angiotensin II and sex hormone in type 2 diabetic rats with erectile dysfunction","volume":"8","author":"Zhang","year":"2020","journal-title":"Sex Med"},{"key":"R56-20261029","doi-asserted-by":"crossref","first-page":"1414958","DOI":"10.3389\/fendo.2024.1414958","article-title":"Causal association between antidiabetic drugs and erectile dysfunction: evidence from Mendelian randomization","volume":"15","author":"Lin","year":"2024","journal-title":"Front Endocrinol (Lausanne)"},{"key":"R57-20261029","doi-asserted-by":"crossref","first-page":"578","DOI":"10.21037\/tau-2024-751","article-title":"Prevalence and determinants of erectile dysfunction among male type 2 diabetes mellitus patients with chronic kidney disease: a cross-sectional study","volume":"14","author":"Muniandy","year":"2025","journal-title":"Transl Androl Urol"},{"key":"R58-20261029","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.2174\/0113895575413887251001111806","article-title":"The art and science of antidiabetic medications and obesity management","volume":"25","author":"Sawhney","year":"2025","journal-title":"Mini Rev Med Chem"},{"key":"R59-20261029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13679-020-00419-5","article-title":"Drugs affecting body weight, body fat distribution, and metabolic function-mechanisms and possible therapeutic or preventive measures: an update","volume":"10","author":"Verhaegen","year":"2021","journal-title":"Curr Obes Rep"},{"key":"R60-20261029","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/164_2021_574","article-title":"Novel drugs for diabetes therapy","volume":"274","author":"Heise","year":"2022","journal-title":"Handb Exp Pharmacol"},{"key":"R61-20261029","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/andr.13484","article-title":"Meta-analysis and construction of simple-to-use nomograms for approximating testosterone levels gained from weight loss in obese men","volume":"12","author":"Ken-Dror","year":"2024","journal-title":"Andrology"},{"key":"R62-20261029","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ejim.2025.06.010","article-title":"A holistic view of SGLT2 inhibitors: from cardio-renal management to cognitive and andrological aspects","volume":"138","author":"Cannarella","year":"2025","journal-title":"Eur J Intern Med"},{"key":"R63-20261029","doi-asserted-by":"crossref","first-page":"107728","DOI":"10.1016\/j.jdiacomp.2020.107728","article-title":"Estradiol correlates with erectile dysfunction and its severity in type 2 diabetic patients","volume":"34","author":"De Rocco Ponce","year":"2020","journal-title":"J Diabetes Complications"},{"key":"R64-20261029","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s13643-023-02303-4","article-title":"The experiences and barriers in addressing type 2 diabetes mellitus-associated erectile dysfunction: a mixed method systematic review","volume":"12","author":"Hadisuyatmana","year":"2023","journal-title":"Syst Rev"},{"key":"R65-20261029","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/dom.12849","article-title":"Efficacy and safety of glucagon-like peptide-1 receptor agonists in type 2 diabetes: a systematic review and mixed-treatment comparison analysis","volume":"19","author":"Htike","year":"2017","journal-title":"Diabetes Obes Metab"},{"key":"R66-20261029","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.3390\/biom15091284","article-title":"The impact of glucagon-like peptide-1 receptor agonists on erectile function: friend or foe?","volume":"15","author":"Kounatidis","year":"2025","journal-title":"Biomolecules"},{"key":"R67-20261029","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/s41443-025-01061-2","article-title":"Male sexual dysfunction associated with GLP-1 receptor agonists: a cross-sectional analysis of FAERS data","volume":"37","author":"Langroudi","year":"2025","journal-title":"Int J Impot Res"},{"key":"R68-20261029","doi-asserted-by":"crossref","first-page":"qeag015","DOI":"10.1093\/sxmrev\/qeag015","article-title":"GLP-1 receptor agonists and sexual function in women and men: a narrative review of emerging evidence and the need for further research","volume":"14","author":"Merhi","year":"2026","journal-title":"Sex Med Rev"},{"key":"R69-20261029","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S2213-8587(21)00115-7","article-title":"Erectile function in men with type 2 diabetes treated with dulaglutide: an exploratory analysis of the rewind placebo-controlled randomised trial","volume":"9","author":"Bajaj","year":"2021","journal-title":"Lancet Diabetes Endocrinol"},{"key":"R70-20261029","doi-asserted-by":"crossref","first-page":"e18583","DOI":"10.1097\/MD.0000000000018583","article-title":"Erectile dysfunction and associated risk factors in male patients with ischemic stroke: a cross-sectional study","volume":"99","author":"Dai","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"R71-20261029","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1016\/j.jsxm.2021.09.016","article-title":"Erectile dysfunction is a modifiable risk factor for major depressive disorder: analysis of a federated research network","volume":"18","author":"Nackeeran","year":"2021","journal-title":"J Sex Med"},{"key":"R72-20261029","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s12902-024-01815-x","article-title":"Erectile dysfunction and associated factors among patients with diabetes in public hospitals of Harari region, Eastern Ethiopia: modified poisson regression model","volume":"24","author":"Seyoum","year":"2024","journal-title":"BMC Endocr Disord"},{"key":"R73-20261029","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1016\/j.jsxm.2021.09.007","article-title":"Nox1\/4 inhibitor GKT-137831 improves erectile function in diabetic rats by ROS reduction and endothelial nitric oxide synthase reconstitution","volume":"18","author":"Zhou","year":"2021","journal-title":"J Sex Med"},{"key":"R74-20261029","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/jsxmed\/qdae129","article-title":"Niclosamide attenuates erectile dysfunction and corporal fibrosis via reversal of smad signaling in diabetic rat model","volume":"21","author":"Engin","year":"2024","journal-title":"J Sex Med"},{"key":"R75-20261029","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jsxm.2021.10.001","article-title":"Effects of stem cell therapy on diabetic mellitus erectile dysfunction: a systematic review and meta-analysis","volume":"19","author":"Yao","year":"2022","journal-title":"J Sex Med"},{"key":"R76-20261029","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.sxmr.2019.09.006","article-title":"Current status and prospects in the treatment of erectile dysfunction by adipose-derived stem cells in the diabetic animal model","volume":"8","author":"Yan","year":"2020","journal-title":"Sex Med Rev"},{"key":"R77-20261029","doi-asserted-by":"crossref","first-page":"197","DOI":"10.21037\/tau-22-511","article-title":"Study on the mechanism of aging-related erectile dysfunction based on bioinformatics and experimental verification","volume":"12","author":"Sun","year":"2023","journal-title":"Transl Androl Urol"},{"key":"R78-20261029","doi-asserted-by":"crossref","first-page":"qfaf078","DOI":"10.1093\/sexmed\/qfaf078","article-title":"A cross-species multi-omics analyze uncovers conserved molecular mechanisms underlying age-related erectile dysfunction","volume":"13","author":"Long","year":"2025","journal-title":"Sex Med"},{"key":"R79-20261029","doi-asserted-by":"crossref","first-page":"887486","DOI":"10.3389\/fendo.2022.887486","article-title":"Comparative transcriptome analyses of geriatric rats associate age-related erectile dysfunction with a lncRNA-miRNA-mRNA regulatory network","volume":"13","author":"Zhou","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"R80-20261029","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1007\/s11096-020-01194-y","article-title":"Pharmacological treatment and inappropriate prescriptions for patients with erectile dysfunction","volume":"43","author":"Valladales-Restrepo","year":"2021","journal-title":"Int J Clin Pharm"},{"key":"R81-20261029","doi-asserted-by":"crossref","first-page":"101668","DOI":"10.1016\/j.jsps.2023.06.001","article-title":"Polypharmacy in chronic liver disease patients: implications for disease severity, drug-drug interaction, and quality of life","volume":"31","author":"Farooq","year":"2023","journal-title":"Saudi Pharm J"},{"key":"R82-20261029","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.3390\/cancers16132377","article-title":"Non-insulin antidiabetic agents and lung cancer risk in drug-naive patients with type 2 diabetes mellitus: a nationwide retrospective cohort study","volume":"16","author":"Tabernacki","year":"2024","journal-title":"Cancers (Basel)"},{"key":"R83-20261029","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1097\/EDE.0000000000001245","article-title":"Comparison of antihypertensive drug classes for dementia prevention","volume":"31","author":"Walker","year":"2020","journal-title":"Epidemiology"},{"key":"R84-20261029","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/andr.70067","article-title":"Unraveling the intersection of sleep disorders and erectile dysfunction: outcomes from two EPISONO editions","volume":"14","author":"Andersen","year":"2026","journal-title":"Andrology"},{"key":"R85-20261029","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/jsxmed\/qdad163","article-title":"Princeton IV consensus guidelines: PDE5 inhibitors and cardiac health","volume":"21","author":"Kloner","year":"2024","journal-title":"J Sex Med"},{"key":"R86-20261029","doi-asserted-by":"crossref","first-page":"1671482","DOI":"10.3389\/fendo.2025.1671482","article-title":"Single-cell atlas of human penile corpus cavernosum reveals cellular and functional heterogeneity of aging-related erectile dysfunction","volume":"16","author":"Zhang","year":"2025","journal-title":"Front Endocrinol (Lausanne)"},{"key":"R87-20261029","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/14622416.2025.2504865","article-title":"Hypertension precision medicine: the promise and pitfalls of pharmacogenomics","volume":"26","author":"Le","year":"2025","journal-title":"Pharmacogenomics"},{"key":"R88-20261029","doi-asserted-by":"crossref","first-page":"1615402","DOI":"10.3389\/fendo.2025.1615402","article-title":"Age-related differences of serum total testosterone and psychological factors in patients with erectile dysfunction","volume":"16","author":"Yang","year":"2025","journal-title":"Front Endocrinol (Lausanne)"},{"key":"R89-20261029","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1111\/andr.13372","article-title":"Determinants of sexual function in men living with HIV younger than 50 years old: focus on organic, relational, and psychological issues","volume":"11","author":"De Vincentis","year":"2023","journal-title":"Andrology"}],"container-title":["Asian Journal of Andrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aja202621","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T13:00:41Z","timestamp":1793278841000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aja202621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":89,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/aja202621","relation":{},"ISSN":["1008-682X","1745-7262"],"issn-type":[{"value":"1008-682X","type":"print"},{"value":"1745-7262","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,31]]},"assertion":[{"value":"2025-12-17","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-30","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}