{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:47:51Z","timestamp":1791913671819,"version":"4.3.4"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n This retrospective study evaluated whether early diagnosis and resection of M\u00fcllerian duct remnants (MDRs) improve outcomes in hypospadias repair. We analyzed patients with hypospadias and coexisting MDRs treated at The First Affiliated Hospital of Sun Yat-sen University (Guangzhou, China) from August 2003 and June 2024. Patients were divided into a study group (\n n<\/jats:italic>\n = 22, MDR resection before urethroplasty) and a control group (\n n<\/jats:italic>\n = 40, no MDR resection before urethroplasty). MDRs were diagnosed using voiding cystourethrography and cystoscopy. Compared with the control group, the study group had more severe MDRs and hypospadias. No major intraoperative complications occurred during MDR resection, except for urine leakage from the remnant stump in two patients. The success rate of urethroplasty was significantly greater in the study group than that in the control group (36.4%\n vs<\/jats:italic>\n 10.0%,\n P<\/jats:italic>\n = 0.019). In the control group, seven patients required salvage MDR resection because of recurrent fistulas. The incidence of postoperative epididymitis was significantly greater in the control group (20.0%\n vs<\/jats:italic>\n 0,\n P<\/jats:italic>\n = 0.042). Compared with the control group, the study group underwent significantly fewer total reoperations (mean \u00b1 s.d.: 1.0 \u00b1 1.6\n vs<\/jats:italic>\n 2.8 \u00b1 3.5,\n P<\/jats:italic>\n = 0.003), fewer fistula repairs (mean \u00b1 s.d.: 0.6 \u00b1 0.7\n vs<\/jats:italic>\n 1.9 \u00b1 2.2,\n P<\/jats:italic>\n = 0.044), and fewer urethral dilations (mean \u00b1 s.d.: 0.2 \u00b1 0.5\n vs<\/jats:italic>\n 1.1 \u00b1 2.2,\n P<\/jats:italic>\n = 0.047). These findings suggest that early diagnosis and resection of MDRs improve urethroplasty outcomes, reduce complications, and decrease reoperations, supporting the incorporation of this approach into routine clinical management for hypospadias.\n <\/jats:p>","DOI":"10.4103\/aja202648","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:01:53Z","timestamp":1791910913000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Early diagnosis and resection of M\u00fcllerian duct remnants: a strategy to improve outcomes in hypospadias repair"],"prefix":"10.4103","author":[{"given":"Peng","family":"Luo","sequence":"first","affiliation":[{"name":"Reproductive Medicine Center, The Key Laboratory for Reproductive Medicine of Guangdong Province, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeng-Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Ting","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou 510620, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hua","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Andrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Ming","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Urology, The First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Gen","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"R1-20261013","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000521381","article-title":"Monogenic forms of DSD: an update","volume":"96","author":"McElreavey","year":"2023","journal-title":"Horm Res 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