{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T05:41:52Z","timestamp":1649137312221},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"vor","delay-in-days":1229,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Avicenna J Med"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We are reporting an unusual case of lymphoepithelial-like carcinoma (LELC) in an 8-year-old female patient where the tumor cells showed unusual CD4 expression. The lesion was found in the left submandibular neck region, in the vicinity of the submandibular gland. The salivary gland was not infiltrated by the tumor, and the tumor exhibited a classic LELC with single and clusters of tumor cells surrounded by many hematolymphoid cells. The tumor cells revealed strong positivity for Epstein\u2013Bar virus as confirmed by the EBER: Epstein-Barr Virus in situ hybridization (EBER-ISH) method of staining. Interestingly, the tumor cells expressed membranous immunostaining for the T-helper lymphocyte antibody (CD4) in addition to pan-cytokeratin. A brief discussion about this unusual finding is offered. The patient was treated as a case of Epstein\u2013Bar virus-associated nasopharyngeal carcinoma with excellent response.<\/jats:p>","DOI":"10.4103\/ajm.ajm_135_17","type":"journal-article","created":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T10:52:41Z","timestamp":1523011961000},"page":"58-62","source":"Crossref","is-referenced-by-count":1,"title":["CD4-positive lymphoepithelial-like carcinoma: Report of unusual case"],"prefix":"10.1055","volume":"8","author":[{"given":"Luaay","family":"Aziz","sequence":"additional","affiliation":[{"name":"Department of Ent and Head and Neck Surgery, Healthpoint Hospital, Abu Dhabi, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raya","family":"Saab","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toufic","family":"Eid","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, American University of Beirut, Beirut, Lebanon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mousa A","family":"Al-Abbadi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,8,12]]},"reference":[{"key":"ref1","first-page":"977","volume-title":"Management of infrequent cancers of childhood","author":"E C Douglass","year":"1977"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1053\/j.semdp.2014.12.004","article-title":"Lymphoepithelial-like carcinomas of the head and neck","volume":"32","author":"B M Wenig","year":"2015","journal-title":"Semin Diagn Pathol"},{"key":"ref3","first-page":"115","article-title":"Nasopharyngeal carcinoma in children and adolescents in Tunisia: Clinical aspects and the paraneoplastic syndrome","volume":"20","author":"R Ellouz","year":"1978","journal-title":"IARC Sci Publ"},{"key":"ref4","first-page":"305","article-title":"International variations in the incidence of childhood carcinomas","volume":"3","author":"C A Stiller","year":"1994","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/newbio244245a0","article-title":"EB viral genomes in epithelial nasopharyngeal carcinoma cells","volume":"244","author":"H Wolf","year":"1973","journal-title":"Nat New Biol"},{"key":"ref6","first-page":"61","article-title":"Results of radiotherapy and adjuvant chemotherapy in the treatment of nasopharyngeal cancer in young patients. 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