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Prophylactic mastectomy is one of the growing strategies of breast cancer risk reduction that is of a special importance for breast cancer gene mutation carriers. Women with personal history of cancerous breast lesions may consider ipsilateral or contralateral mastectomy as well. Existing data showed that mastectomy effectively reduces breast cancer risk. However, careful risk estimation is necessary to wisely select individuals who will benefit from preventing breast cancer.<\/jats:p>","DOI":"10.4103\/ajm.ajm_21_18","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T05:31:35Z","timestamp":1531287095000},"page":"67-77","source":"Crossref","is-referenced-by-count":69,"title":["Prophylactic mastectomy for the prevention of breast cancer: Review of the literature"],"prefix":"10.1055","volume":"8","author":[{"given":"Rawan K.","family":"Alaofi","sequence":"additional","affiliation":[{"name":"Taibah University College of Medicine, Medina, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed O.","family":"Nassif","sequence":"additional","affiliation":[{"name":"Department of Surgery, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwan R.","family":"Al-Hajeili","sequence":"additional","affiliation":[{"name":"Department of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2021,8,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21332","article-title":"Cancer statistics, 2016","volume":"66","author":"R L Siegel","year":"2016","journal-title":"CA Cancer J Clin"},{"key":"ref3","first-page":"901046","article-title":"Contralateral risk-reducing mastectomy: Review of risk factors and risk-reducing strategies","volume":"2015","author":"N N Basu","year":"2015","journal-title":"Int J Surg Oncol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1200\/JCO.2015.62.3504","article-title":"Annual hazard rates of recurrence for breast cancer during 24 years of follow-up: Results from the international breast cancer study group trials I to V","volume":"34","author":"M Colleoni","year":"2016","journal-title":"J Clin Oncol"},{"key":"ref5","first-page":"1319","article-title":"Current status of prophylactic mastectomy","volume":"16","author":"K Ghosh","year":"2002","journal-title":"Oncology (Williston Park)"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S1097-2765(00)80202-6","article-title":"Brca1 controls homology-directed DNA repair","volume":"4","author":"M E Moynahan","year":"1999","journal-title":"Mol Cell"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0092-8674(00)81847-4","article-title":"Association of BRCA1 with rad51 in mitotic and meiotic cells","volume":"88","author":"R Scully","year":"1997","journal-title":"Cell"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.dnarep.2014.03.014","article-title":"DNA double-strand break repair pathway choice and cancer","volume":"19","author":"T Aparicio","year":"2014","journal-title":"DNA Repair (Amst)"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S1097-2765(01)00174-5","article-title":"BRCA2 is required for homology-directed repair of chromosomal breaks","volume":"7","author":"M E Moynahan","year":"2001","journal-title":"Mol Cell"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S1097-2765(00)80035-0","article-title":"Involvement of brca2 in DNA repair","volume":"1","author":"K J Patel","year":"1998","journal-title":"Mol Cell"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0092-8674(02)00615-3","article-title":"Cancer susceptibility and the functions of BRCA1 and BRCA2","volume":"108","author":"A R Venkitaraman","year":"2002","journal-title":"Cell"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1086\/375033","article-title":"Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: A combined analysis of 22 studies.","volume":"72","author":"A Antoniou","year":"2003","journal-title":"Am J Hum Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1200\/JCO.2006.09.1066","article-title":"Meta-analysis of BRCA1 and BRCA2 penetrance","volume":"25","author":"S Chen","year":"2007","journal-title":"J Clin Oncol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s10549-010-0805-3","article-title":"van der Kolk DM, de Bock GH, Leegte BK, Schaapveld M, Mourits MJ, de Vries J, et al. 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