{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T13:31:29Z","timestamp":1783776689082,"version":"3.55.0"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":1383,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian J Neurosurg"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>Context: Ventriculoperitoneal (VP) shunt and endoscopic third ventriculostomy (ETV) are the established surgical treatments for obstructive hydrocephalus (HCP). Powerful evidence regarding the best therapeutic approach for infants with obstructive HCP is lacked. Aims: Comparison of the therapeutic efficacy of VP shunt and ETV\/choroid plexus cauterization (CPC) in infants with obstructive HCP. Settings and Design: This was a randomized, active control, unblind, single-center, clinical trial. Methods: Infants with obstructive HCP were randomly allocated to each intervention group (ETV\/CPC or VP shunt). They were monitored for at least 6 months for any sign of raised intracranial pressure (rICP). The recurrence of rICP signs requiring surgical intervention was considered as intervention failure. Statistical Analysis: The association between intervention group and outcome was tested with Chi-square test, and P = 0.05 or less was considered statistically significant. Results: Of the total fifty patients entering the study, 49 were included in the final analysis, 27 of them were in VP shunt and 22 in ETV\/CPC group. Seventeen patients (34%) were female and 33 (66%) were male with mean age of 3.74 \u00b1 3.1 months (range = 10 days \u2013 11 months). Thirty-nine (79.6%) were under 6 months of age and the remaining were 6 months or older. The overall success rate in 36-month follow-up was 88.5% and 68.2% for VP shunt and ETV\/CPC, respectively, with the difference being not statistically significant. Conclusion: The current study determined no inferiority of ETV\/CPC compared to VP shunt, and therefore, it may become an efficient treatment for obstructive HCP in infants.<\/jats:p>","DOI":"10.4103\/ajns.ajns_63_17","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T12:01:21Z","timestamp":1524657681000},"page":"1042-1047","source":"Crossref","is-referenced-by-count":14,"title":["Controlled trial to compare therapeutic efficacy of endoscopic third ventriculostomy plus choroid plexus cauterization with ventriculoperitoneal shunt in infants with obstructive hydrocephalus"],"prefix":"10.1055","volume":"13","author":[{"given":"Amir","family":"Navaei","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Science, Tehran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Hanaei","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Children's Hospital Medical Center, Tehran University of Medical Science, Tehran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohreh","family":"Habibi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Children's Hospital Medical Center, Tehran University of Medical Science, Tehran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morteza","family":"Jouibari","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Science, Tehran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Heidari","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Children's Hospital Medical Center, Tehran University of Medical Science, Tehran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soheil","family":"Naderi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Children's Hospital Medical Center, Tehran University of Medical Science, Tehran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farideh","family":"Nejat","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Children's Hospital Medical Center, Tehran University of Medical Science, Tehran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"key-10.4103\/1793-5482.231077-1","first-page":"1111","volume-title":"Hydrocephalus in children born in 1999-2002: epidemiology, outcome and ophthalmological findings","author":"Persson","year":"2007","journal-title":"Childs Nerv Syst"},{"key":"key-10.4103\/1793-5482.231077-2","first-page":"294","volume-title":", et al. Randomized trial of cerebrospinal fluid shunt valve design in pediatric hydrocephalus","author":"Drake","year":"1998","journal-title":"Neurosurgery"},{"key":"key-10.4103\/1793-5482.231077-3","first-page":"3","volume-title":"Endoscopic third ventriculostomy for shunt malfunction: What to do with the shunt?","author":"Neils","year":"2013","journal-title":"Surg Neurol Int","ISSN":"https:\/\/id.crossref.org\/issn\/2152-7806","issn-type":"print"},{"key":"key-10.4103\/1793-5482.231077-4","first-page":"881","volume-title":"Endoscopic third ventriculostomy in pediatric patients: the Canadian experience","author":"Drake","year":"2007","journal-title":"Neurosurgery"},{"key":"key-10.4103\/1793-5482.231077-5","first-page":"1323","volume-title":"The role of endoscopic third ventriculostomy in the management of shunt malfunction","author":"Cinalli","year":"1998","journal-title":"Neurosurgery"},{"key":"key-10.4103\/1793-5482.231077-6","first-page":"ONS168","volume-title":"Complications of endoscopic third ventriculostomy in previously shunted patients","author":"Hader","year":"2008","journal-title":"Neurosurgery"},{"key":"key-10.4103\/1793-5482.231077-7","first-page":"861","volume-title":"The role of endoscopic third ventriculostomy in adult patients with hydrocephalus","author":"Jenkinson","year":"2009","journal-title":"J Neurosurg"},{"key":"key-10.4103\/1793-5482.231077-8","first-page":"393","volume-title":"Endoscopic third ventriculostomy: an outcome analysis of primary cases and procedures performed after ventriculoperitoneal shunt malfunction","author":"O'Brien","year":"2005","journal-title":"J Neurosurg"},{"key":"key-10.4103\/1793-5482.231077-9","first-page":"43","volume-title":"Mechanisms of failure after endoscopic third ventriculostomy in young infants","author":"Wagner","year":"2005","journal-title":"J Neurosurg"},{"key":"key-10.4103\/1793-5482.231077-10","first-page":"405","volume-title":"Endoscopic third ventriculostomy in infants of less than 1 year of age: which factors influence the outcome?","author":"Koch","year":"2004","journal-title":"Childs Nerv Syst"},{"key":"key-10.4103\/1793-5482.231077-11","first-page":"296","volume-title":"Pediatric hydrocephalus in East Africa: prevalence, causes, treatments, and strategies for the future","author":"Warf","year":"2010","journal-title":"World Neurosurg"},{"key":"key-10.4103\/1793-5482.231077-12","first-page":"204","volume-title":"Intraoperative assessment of cerebral aqueduct patency and cisternal scarring: impact on success of endoscopic third ventriculostomy in 403 African children","author":"Warf","year":"2010","journal-title":"J Neurosurg Pediatr"},{"key":"key-10.4103\/1793-5482.231077-13","first-page":"1","volume-title":"Small size craniotomy in endoscopic procedures: Technique and advantages","author":"Arjipour","year":"2015","journal-title":"J Pediatr Neurosci","ISSN":"https:\/\/id.crossref.org\/issn\/1817-1745","issn-type":"print"},{"key":"key-10.4103\/1793-5482.231077-14","unstructured":"Blackwelder WC. Equivalence trials. Encyclopedia of Biostatistics. New York: Biostatistics; John Wiley and Sons; 1998."},{"key":"key-10.4103\/1793-5482.231077-15","doi-asserted-by":"crossref","unstructured":"Chow SC, Wang H, Shao J. Sample Size Calculations in Clinical Research. New York: Basel CRC, Research Marcel Dekker Inc; 2007.","DOI":"10.1201\/9781584889830"},{"key":"key-10.4103\/1793-5482.231077-16","first-page":"131","volume-title":"The impact of endoscopic third ventriculostomy on the management of newly diagnosed hydrocephalus in infants","author":"Javadpour","year":"2001","journal-title":"Pediatr Neurosurg"},{"key":"key-10.4103\/1793-5482.231077-17","first-page":"591","volume-title":"Hydrocephalus 2005 International Consensus Meeting, Queenstown, New Zealand, 15-17 August 2005","author":"Joedicke","year":"2005","journal-title":"Childs Nerv Syst"},{"key":"key-10.4103\/1793-5482.231077-18","first-page":"151","volume-title":"Analysis of the success and failure of endoscopic third ventriculostomy in infants less than 1 year of age","author":"Balthasar","year":"2007","journal-title":"Childs Nerv Syst"},{"key":"key-10.4103\/1793-5482.231077-19","first-page":"494","volume-title":"Evaluating the children's hospital of Alabama endoscopic third 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