{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T19:23:31Z","timestamp":1793733811349,"version":"4.6.1"},"reference-count":153,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":1383,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian J Neurosurg"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>Skull base osteomyelitis (SBO) is a complex and fatal clinical entity that is often misdiagnosed for malignancy. SBO is commonly a direct complication of otogenic, sinogenic, odontogenic, and rhinogenic infections and can present as central, atypical, or pediatric clival SBO. This review describes the clinical profi le, investigational approach, and management techniques for these variants. A comprehensive literature review was performed in PubMed, MEDLINE, Research Gate, EMBASE, Wiley Online Library, and various Neurosurgical and Neurology journals with the keywords including: SBO, central or atypical SBO, fungal osteomyelitis, malignant otitis externa, temporal bone osteomyelitis, and clival osteomyelitis. Each manuscript's reference list was reviewed for potentially relevant articles. The search yielded a total of 153 articles. It was found that with early and aggressive culture guided long-term intravenous broad-spectrum antibiotic therapy decreases post-infection complications. In cases of widespread soft tissue involvement, an early aggressive surgical removal of infectious sequestra with preferentially Hyperbaric Oxygen (HBO) therapy is associated with better prognosis of disease, less neurologic sequelae and mortality rate. Complete resolution of the SBO cases may take several months. Since early treatment can improve mortality rates, it is paramount that the reporting radiologists and treating clinicians are aware of the cardinal diagnostic signs to improve clinical outcomes of the disease. It will decrease delayed diagnosis and under treatment of the condition. However, due to rarity of the condition, complete prognostic factors have not fully been analyzed and discussed in the literature.<\/jats:p>","DOI":"10.4103\/ajns.ajns_90_17","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T12:01:21Z","timestamp":1524657681000},"page":"959-970","source":"Crossref","is-referenced-by-count":138,"title":["A comprehensive review of skull base osteomyelitis: Diagnostic and therapeutic challenges among various presentations"],"prefix":"10.1055","volume":"13","author":[{"given":"Muhammad","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, California Institute of Neuroscience, Thousand Oaks, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed","family":"Quadri","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, California Institute of Neuroscience, Thousand Oaks, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulmuqueeth","family":"Kazmi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Windsor University School of Medicine, Brighton's Estate, Cayon, St. Kitts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Kwatra","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, California Institute of Neuroscience, Thousand Oaks, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anirudh","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Gustin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Advocate BroMenn Medical Center, Normal, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mudassir","family":"Farooqui","sequence":"additional","affiliation":[{"name":"University of Oklahoma Health Sciences Center, Oklahoma City, OK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajid","family":"Suriya","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, California Institute of Neuroscience, Thousand Oaks, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atif","family":"Zafar","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of New Mexico, Albuquerque, NM"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"key-10.4103\/1793-5482.231086-1","unstructured":"Nelaton A. Elements of Surgical Pathology. Vol. 586. Paris: Germer Bailliere; 1844. p. 595-7."},{"key":"key-10.4103\/1793-5482.231086-2","unstructured":"Wilensky AO. Osteomyelitis; its Pathogenesis, Symptomatology and Treatment. New York: Macmillan Company; 1934."},{"key":"key-10.4103\/1793-5482.231086-3","unstructured":"Hunter J. Lectures on the principles of surgery. In: Palmer JF, editor. The Works of John Hunter FRS. Vol. 1. London: Longman, Rees, Orme, Brown, Green and Longman; 1835."},{"key":"key-10.4103\/1793-5482.231086-4","unstructured":"Bromfield W. Chirurgical Observations and Cases. Vol. II. London: T. Cadall; 1773. p. 19-24."},{"key":"key-10.4103\/1793-5482.231086-5","unstructured":"Pott P. Observations on the Nature and Consequences of Those Injuries to Which the Head Is Liable from External Violence. London: L Hawes, W Clarke, R Collins; 1768."},{"key":"key-10.4103\/1793-5482.231086-6","unstructured":"Lannelongue OM. Acute osteomyelitis during growth. Paris: Asselin and Cie; 1879."},{"key":"key-10.4103\/1793-5482.231086-7","first-page":"449","volume-title":"Die osteomyelitis traumatica purulenta cranii","author":"Fischer","year":"1900","journal-title":"Deut Zeit Chir"},{"key":"key-10.4103\/1793-5482.231086-8","unstructured":"Luc H. Killian's method for the radical cure of chronic frontal empyema. Annals of Ear Diseases, Larynx, Nezet of the Pharynx. Paris: Masson & Cie; 1902."},{"key":"key-10.4103\/1793-5482.231086-9","first-page":"197","volume-title":"Remarks on the operative treatment of a case of double frontal sinus empyema, complicated by double antral suppuration","author":"Tilley","year":"1897","journal-title":"Br Med J"},{"key":"key-10.4103\/1793-5482.231086-10","first-page":"1300","volume-title":"Pyocyaneous osteomyelitis of the temporal bone, mandible and zygoma","author":"Meltzer","year":"1959","journal-title":"Laryngoscope"},{"key":"key-10.4103\/1793-5482.231086-11","first-page":"316","volume-title":"Osteomyelitis: A review of clinical features, therapeutic considerations and unusual aspects 3.Osteomyelitis associated with vascular insufficiency","author":"Waldvogel","year":"1970","journal-title":"N Engl J Med"},{"key":"key-10.4103\/1793-5482.231086-12","first-page":"194","volume-title":"Osteomyelitis in the head and neck","author":"Prasad","year":"2007","journal-title":"Acta Otolaryngol"},{"key":"key-10.4103\/1793-5482.231086-13","first-page":"352","volume-title":"Acute osteomyelitis in children","author":"Peltola","year":"2014","journal-title":"N Engl J Med"},{"key":"key-10.4103\/1793-5482.231086-14","first-page":"402","volume-title":"Osteomyelitis of the skull base \u2013 An unusual manifestation","author":"Amedee","year":"1989","journal-title":"Am J Otol"},{"key":"key-10.4103\/1793-5482.231086-15","first-page":"1059","volume-title":"Osteomyelitis in the head and neck","author":"Balm","year":"1985","journal-title":"J Laryngol Otol"},{"key":"key-10.4103\/1793-5482.231086-16","first-page":"108","volume-title":"Malignant external otitis and osteomyelitis of the base of the skull","author":"Chandler","year":"1989","journal-title":"Am J Otol"},{"key":"key-10.4103\/1793-5482.231086-17","first-page":"245","volume-title":"Osteomyelitis of the base of the skull","author":"Chandler","year":"1986","journal-title":"Laryngoscope"},{"key":"key-10.4103\/1793-5482.231086-18","first-page":"1097","volume-title":"Propionibacterium acnes: An under-appreciated cause of post-neurosurgical infection","author":"Nisbet","year":"2007","journal-title":"J Antimicrob Chemother"},{"key":"key-10.4103\/1793-5482.231086-19","unstructured":"Mortazavi MM, Khan MA, Quadri SA, Suriya SS, Fahimdanesh KM, et al. Cranial Osteomyelitis: A Comprehensive Review of Modern Therapies. World Neurosurg. 2017. pii: S1878-8750(17)32182-4."},{"key":"key-10.4103\/1793-5482.231086-20","first-page":"168","volume-title":"Osteomyelitis of the skull vault from a human bite","author":"Phillips","year":"1997","journal-title":"Br J Neurosurg"},{"key":"key-10.4103\/1793-5482.231086-21","first-page":"287","volume-title":"Hyperbaric oxygen treatment of postoperative neurosurgical infections","author":"Larsson","year":"2002","journal-title":"Neurosurgery"},{"key":"key-10.4103\/1793-5482.231086-22","first-page":"308","volume-title":"Challenges in managing pediatric osteomyelitis in the developing world: Analysis of cases presenting to a tertiary referral centre in Tanzania","author":"Ali","year":"2014","journal-title":"Afr J Paediatr Surg","ISSN":"https:\/\/id.crossref.org\/issn\/0189-6725","issn-type":"print"},{"key":"key-10.4103\/1793-5482.231086-23","first-page":"872","volume-title":"Craniotomy improves outcomes for cranial subdural empyemas: Computed tomography-era experience with 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Plast Surg"},{"key":"key-10.4103\/1793-5482.231086-44","first-page":"45","volume-title":"Low-velocity penetrating craniocerebral injury in childhood","author":"Domingo","year":"1994","journal-title":"Pediatr Neurosurg"},{"key":"key-10.4103\/1793-5482.231086-45","first-page":"S364","volume-title":"Extensive, non-healing scalp ulcer associated with trauma-induced chronic osteomyelitis","author":"Valer\u00f3n-Almaz\u00e1n","year":"2011","journal-title":"Ann Dermatol"},{"key":"key-10.4103\/1793-5482.231086-46","first-page":"10","volume-title":"Cranium osteomyelitis following gunshot","author":"Margorin","year":"1946","journal-title":"Voen Med Zh"},{"key":"key-10.4103\/1793-5482.231086-47","first-page":"8","volume-title":"Anti-epileptic prophylaxis in traumatic brain injury: A retrospective analysis of patients undergoing craniotomy versus decompressive craniectomy","author":"Ramakrishnan","year":"2015","journal-title":"Surg Neurol 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Osteomyelitis of jaws. In: Topazian RG, Goldberg MH, editors. Oral and Maxillofacial Infections. 3rd ed. Philadelphia, PA: Saunders; 1994. p. 251-86."},{"key":"key-10.4103\/1793-5482.231086-52","first-page":"236","volume-title":"Highly differentiated squamous epithelial carcinoma as a late complication of post-traumatic osteomyelitis","author":"Wickenhauser","year":"1999","journal-title":"Pathologe"},{"key":"key-10.4103\/1793-5482.231086-53","first-page":"73","volume-title":"Osteomyelitis of the craniofacial skeleton","author":"Pincus","year":"2009","journal-title":"Semin Plast Surg"},{"key":"key-10.4103\/1793-5482.231086-54","first-page":"233","volume-title":"Brain abscess secondary to frontal osteomyelitis","author":"Tuon","year":"2006","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"key-10.4103\/1793-5482.231086-55","first-page":"666","volume-title":"Otogenic cranial base osteomyelitis: A proposed prognosis-based system for disease classification","author":"Lee","year":"2008","journal-title":"Otol 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Surg"},{"key":"key-10.4103\/1793-5482.231086-60","first-page":"422","volume-title":"Observations on cerebral otorrhea: latest considerations","author":"Toulmouche","year":"1838","journal-title":"Gaz Med Paris"},{"key":"key-10.4103\/1793-5482.231086-61","first-page":"1257","volume-title":"Malignant external otitis","author":"Chandler","year":"1968","journal-title":"Laryngoscope"},{"key":"key-10.4103\/1793-5482.231086-62","first-page":"34","volume-title":"The changing face of malignant (necrotising) external otitis: Clinical, radiological, and anatomic correlations","author":"Rubin","year":"2004","journal-title":"Lancet Infect Dis"},{"key":"key-10.4103\/1793-5482.231086-63","first-page":"326","volume-title":"Osteomyelitis of the skull base with atypical onset and evolution","author":"Magliulo","year":"2000","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"key-10.4103\/1793-5482.231086-64","first-page":"121","volume-title":"Skull base osteomyelitis: Diagnostic and therapeutic 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otitis externa due to Aspergillus species: Case report and review","author":"Gordon","year":"1994","journal-title":"Clin Infect Dis"},{"key":"key-10.4103\/1793-5482.231086-74","first-page":"108","volume-title":"Fungal and yeast infections of the central nervous system.A clinical review","author":"Salaki","year":"1984","journal-title":"Medicine (Baltimore)"},{"key":"key-10.4103\/1793-5482.231086-75","first-page":"1365","volume-title":"Invasive aspergillosis of the sphenoid sinus manifested as a pituitary tumor","author":"Fuchs","year":"1985","journal-title":"South Med J"},{"key":"key-10.4103\/1793-5482.231086-76","first-page":"198","volume-title":"Fungal mastoiditis in the immunocompromised host","author":"Stanley","year":"1988","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"key-10.4103\/1793-5482.231086-77","first-page":"1288","volume-title":"Temporal bone osteomyelitis and temporoparietal abscess secondary to malignant otitis 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an unreliable indicator of malignant external otitisresolution","author":"Redleaf","year":"1994","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"key-10.4103\/1793-5482.231086-100","first-page":"215","volume-title":"Multimodality imaging for precise localization of craniofacial osteomyelitis","author":"Strumas","year":"2003","journal-title":"J Craniofac Surg"},{"key":"key-10.4103\/1793-5482.231086-101","first-page":"159","volume-title":"Aspergillosis of the cranial base","author":"Carr","year":"1994","journal-title":"Skull Base Surg"},{"key":"key-10.4103\/1793-5482.231086-102","first-page":"333","volume-title":"Complicated frontal sinusitis: Evaluation and management","author":"Gardiner","year":"1986","journal-title":"Otolaryngol Head Neck Surg"},{"key":"key-10.4103\/1793-5482.231086-103","first-page":"1147","volume-title":"Pott's puffy tumor after acupuncture therapy","author":"Wu","year":"2009","journal-title":"Eur J 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Salmonella species (including typhoid fever). In: Mandell GL, Douglas RG Jr., Bennett JE, editors. Principles and Practice of Infectious Diseases. 3rd ed. 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Rare concurrent retroclival and pan-spinal subdural empyema: Review of literature with an uncommon illustrative case. 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