{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T01:44:12Z","timestamp":1782956652778,"version":"3.54.5"},"reference-count":24,"publisher":null,"issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This prospective comparative study aims to assess the efficacy of fibrin sealant to improve outcomes in paediatric patients operated for hypospadias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Forty consecutive patients with hypospadias were randomised into two groups of twenty patients each. The first group underwent hypospadias repair, technique depending on the type of hypospadias, whereas in the second group, fibrin sealant was used to reinforce the urethroplasty. Assessment was done with respect to the type of hypospadias, type of repair done, operative time, immediate post-operative complications (early ooze and skin flap-related complications), intermediate complications (urethra-cutaneous fistula) and delayed post-operative complications (penile torsion and poor cosmetic outcome) at follow-up. We also compared the overall improvement in outcome among the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      First Group: The mean operative time was 1 h and 45 min. Complications were seen in nine patients: Early ooze (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 2); skin flap-related complications (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 3); fistula (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 7); poor cosmetic outcome (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 7) and penile torsion (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 4). Second Group (Fibrin Sealant): The mean operative time was 1 h and 30 min. Post-operative complications were observed in five patients: Coronal fistula (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 3) and poor cosmetic outcome (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 3). On comparing, the differences in outcomes of ooze, skin flap-related complications and torsion were found to be statistically significant with\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05. The differences in the urethra-cutaneous fistula and cosmetic appearance were not found to be statistically significant. The difference in overall improvement in complications was found to be statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Fibrin sealant, when applied over the urethroplasty suture line as a waterproof cover, may help to improve the outcome in patients with hypospadias.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ajps.ajps_132_20","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T07:38:58Z","timestamp":1716968338000},"page":"215-218","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of Fibrin Sealant as Waterproof Cover in Improving Outcome in Hypospadias Surgery"],"prefix":"10.67481","volume":"18","author":[{"given":"Neha 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