{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T01:44:14Z","timestamp":1782956654743,"version":"3.54.5"},"reference-count":12,"publisher":null,"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,4,10]]},"abstract":"\n Introduction:<\/jats:title>\n Sickle cell disease (SCD) is a haemoglobinopathy that leads to the formation of distorted sickle-shaped red blood cells that are prone to vaso-occlusion. This may lead to vaso-occlusive crises that may affect any organ. Acute pancreatitis (AP) in SCD patients may be mimicked by a vaso-occlusive crisis in the abdomen. The objective of this article is to analyse the clinical profiles of SCD patients with AP and understand the differences in the presentation of AP compared to an abdominal vaso-occlusive crisis and the difference between its presentation in SCD patients in comparison to other patients.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n Twenty-eight SCD patients who were diagnosed with AP during their admission to the paediatric department at a tertiary hospital between January 2012 and December 2020 were retrospectively studied. Patients aged older than 14 years were excluded. The data collected concerned: demographics, the clinical course and the hospital course. The diagnosis and severity protocols followed the revised Atlanta Criteria.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The patients were aged with a mean of 9.61 years. There were 15 males and 13 females. Demographics were not significantly correlated to complication rates (\n P<\/jats:italic>\n > 0.05). The mean duration of hospitalisation was 6.43 days. The most common clinical presentations were abdominal pain, fever, then vomiting and nausea. Three patients experienced complications and they were all cases of cholangitis (10.71%). There were no cases of pseudocysts, acute necrotic collections, pancreatic or peripancreatic necrosis or walled-off necroses. All of the cases of AP in SCD children were mild according to the revised Atlanta classification. Leucocytosis was present in 29.29% of patients and 17.8% of patients had high C-reactive proteins (CRPs). There was no significant correlation between leucocyte counts, CRP levels, serum or urinary amylase levels and complications (\n P<\/jats:italic>\n > 0.05). All patients had haemoglobin (Hb) levels above 7 g\/dL. The levels of sickle Hb ranged from 40 to 70 g\/dL and reticulocyte counts averaged at 3.57%. Haematologic parameters were not significantly correlated with complication rates (\n P<\/jats:italic>\n > 0.05). There were no recurrences.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n AP in SCD patients presented with classic signs and symptoms. There were no associations between demographics and complications. The levels of leucocytes, CRP counts and serum and urinary amylase were not correlated with complications. The level of Hb and sickle cell Hb was not associated with complication rates. Reticulocytes were slightly elevated in SCD patients with AP. More studies are needed to demarcate factors distinguishing AP in SCD from abdominal vaso-occlusive crises.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ajps.ajps_133_22","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T09:00:09Z","timestamp":1723539609000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["The Presentation of Acute Pancreatitis in Sickle Cell Disease Patients"],"prefix":"10.67481","author":[{"given":"Saeed","family":"Al-Hindi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Khalaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AbdelSalam N.","family":"Al-Sousi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":null,"reference":[{"key":"R4-20240814","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1056\/NEJM199507273330402","article-title":"A comparison of conservative and aggressive transfusion regimens in the perioperative management of sickle cell disease. The preoperative transfusion in sickle cell disease study group","volume":"333","author":"Vichinsky","year":"1995","journal-title":"N Engl J Med"},{"key":"R5-20240814","doi-asserted-by":"crossref","first-page":"416","DOI":"10.4291\/wjgp.v5.i4.416","article-title":"Acute pancreatitis in children and adolescents","volume":"5","author":"Suzuki","year":"2014","journal-title":"World J Gastrointest Pathophysiol"},{"key":"R7-20240814","doi-asserted-by":"crossref","first-page":"S91","DOI":"10.14309\/00000434-200809001-00236","article-title":"Prevalance of acute pancreatitis in sickle cell disease: 236","volume":"103","author":"Jasti","year":"2008","journal-title":"J Am Coll Gastroenterol ACG"},{"key":"R8-20240814","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/gutjnl-2012-302779","article-title":"Classification of acute pancreatitis \u2013 2012: Revision of the Atlanta classification and definitions by international consensus","volume":"62","author":"Banks","year":"2013","journal-title":"Gut"},{"key":"R9-20240814","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/ajh.10344","article-title":"Acute pancreatitis during sickle cell vaso-occlusive painful crisis","volume":"73","author":"Ahmed","year":"2003","journal-title":"Am J Hematol"},{"key":"R10-20240814","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.18203\/2349-3291.ijcp20201659","article-title":"Acute pancreatitis in a child with sickle cell anemia","volume":"7","author":"Kumar","year":"2020","journal-title":"Int J Contemp Pediatr"},{"key":"R11-20240814","doi-asserted-by":"crossref","first-page":"994","DOI":"10.2214\/AJR.14.13286","article-title":"CT of gastrointestinal vasoocclusive crisis complicating sickle cell disease","volume":"204","author":"Gardner","year":"2015","journal-title":"AJR Am J Roentgenol"},{"key":"R12-20240814","first-page":"100","article-title":"Abdominal pain in adult sickle cell disease patients: A Nigerian experience","volume":"9","author":"Akingbola","year":"2011","journal-title":"Ann IB Postgrad Med"},{"key":"R13-20240814","doi-asserted-by":"crossref","first-page":"701","DOI":"10.4103\/2141-9248.141523","article-title":"C-reactive protein and disease outcome in Nigerian sickle cell disease patients","volume":"4","author":"Okocha","year":"2014","journal-title":"Ann Med Health Sci Res"},{"key":"R14-20240814","doi-asserted-by":"crossref","first-page":"52","DOI":"10.18502\/sjms.v14i1.4381","article-title":"Clinical and biochemical manifestations of severe sickle cell anemia in adult patients in steady state in Ile-Ife, Nigeria","volume":"14","author":"Oluwagbenga","year":"2019","journal-title":"Sudan J Med Sci"},{"key":"R15-20240814","first-page":"021","article-title":"Clinical significance of urinary amylase in acute pancreatitis","volume":"1","author":"Wani","year":"2017","journal-title":"Arch Surg Clin Res"},{"key":"R16-20240814","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1111\/j.1553-2712.1996.tb03510.x","article-title":"The complete blood count and reticulocyte count \u2013Are they necessary in the evaluation of acute vasoocclusive sickle-cell crisis?","volume":"3","author":"Lopez","year":"1996","journal-title":"Acad Emerg Med"}],"container-title":["African Journal of Paediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.4103\/ajps.ajps_133_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:49:38Z","timestamp":1782953378000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.4103\/ajps.ajps_133_22"}},"subtitle":["A Single Hospital Experience"],"short-title":[],"issued":{"date-parts":[[2023,4,10]]},"references-count":12,"URL":"https:\/\/doi.org\/10.4103\/ajps.ajps_133_22","relation":{},"ISSN":["0189-6725"],"issn-type":[{"value":"0189-6725","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4,10]]}}}