{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T01:44:24Z","timestamp":1782956664304,"version":"3.54.5"},"reference-count":13,"publisher":null,"issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>The intraoperative anatomical findings (IOAF) of all ureteropelvic junction obstruction (UPJO) cases are not identical. Moreover, there is also controversy in the literature regarding histopathological (HP) findings in cases of UPJO. In the present study, we evaluated different IOAF and assessed their association with specific HP parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This was a cross-sectional study set-up, which was carried out in a tertiary care centre. Children with UPJO who underwent surgery between 2017 and 2020 were enrolled. The following IOAF were noted: Type of pelvis (extrarenal or intrarenal), insertion of the ureter (high or normal), presence of lower pole crossing vessel (CV), negotiation of UPJ segment with double J stent (3 Fr) and length of internal narrowing (LIN) at UPJ. The resected segment of UPJ was assessed at three levels (pelvis, UPJ and ureter) for various HP parameters including fibrosis, oedema, inflammation and smooth muscle hypertrophy (SMH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Thirty-nine children were included in the study with a mean age of 31 months. The summary statistics of IOAF were intrarenal pelvis in 5 cases, high insertion of the ureter (HIU) in 9, CV in 6, negotiable UPJ in 23, and 16 cases showed LIN &gt;1 cm. All cases showed SMH at the pelvis region and SMH with fibrosis at the UPJ region. At the pelvis region, there was an association between (1) HIU with oedema and chronic inflammation (CIF), (2) CV with CIF and (3) LIN with CIF and SMH. At the UPJ region, there was an association between (1) CV and negotiable UPJ with less fibrosis and (2) LIN with SMH. At the ureteric end, CV showed an association with less fibrosis and more CIF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>All UPJO cases have some common HP findings. Although, some particular IOAF, i.e., presence of CV, negotiable UPJ, HIU and LIN showed association with specific HP parameters.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ajps.ajps_42_22","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T01:02:03Z","timestamp":1674176523000},"page":"206-210","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Association between Intraoperative Anatomical Variation and Histopathological Parameters in Cases of Ureteropelvic Junction Obstruction in Children: A Cross-Sectional Study"],"prefix":"10.67481","volume":"20","author":[{"given":"Shailesh","family":"Solanki","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, PGIMER, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prema","family":"Menon","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, PGIMER, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manasa","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, PGIMER, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayur","family":"Parkhi","sequence":"additional","affiliation":[{"name":"Department of Histopathology, PGIMER, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirti","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Histopathology, PGIMER, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramod K","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, PGIMER, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin James","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, PGIMER, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram","family":"Samujh","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, PGIMER, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":null,"published-online":{"date-parts":[[2023,1,19]]},"reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.urology.2017.05.013","article-title":"Histopathology in ureteropelvic junction obstruction with and without crossing vessels","volume":"107","author":"Cancian","year":"2017","journal-title":"Urology"},{"key":"R2-20240829","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4103\/IJPM.IJPM_535_17","article-title":"Immunohistochemistry and morphometric analysis of pelviureteric junction complexes in children with hydronephrosis","volume":"62","author":"Pan","year":"2019","journal-title":"Indian J Pathol Microbiol"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12301-020-00050-9","article-title":"The prognostic value of histopathological pattern of the pelviureteric junction in the outcome of pyeloplasty in children","volume":"26","author":"Sebaey","year":"2020","journal-title":"Afr J Urol"},{"key":"R4-20240829","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s00467-017-3629-0","article-title":"The molecular biology of pelvi-ureteric junction obstruction","volume":"33","author":"Jackson","year":"2018","journal-title":"Pediatr Nephrol"},{"key":"R5-20240829","doi-asserted-by":"crossref","first-page":"129","DOI":"10.4103\/jiaps.JIAPS_254_16","article-title":"Immunohistochemistry in Ureteropelvic Junction Obstruction and Its Correlation to Postoperative Outcome","volume":"22","author":"Inugala","year":"2017","journal-title":"J Indian Assoc Pediatr Surg"},{"key":"R6-20240829","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3109\/08860220903541101","article-title":"Investigation of histopathologic changes in pelviureteral junction obstruction","volume":"32","author":"Yurtcu","year":"2009","journal-title":"Renal Failure"},{"key":"R7-20240829","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.urology.2008.10.069","article-title":"Pathologic findings in patients with ureteropelvic junction obstruction and crossing vessels","volume":"73","author":"Richstone","year":"2009","journal-title":"Urology"},{"key":"R8-20240829","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.urology.2010.02.007","article-title":"Histologic differences between extrinsic and intrinsic ureteropelvic junction obstruction","volume":"76","author":"Yiee","year":"2010","journal-title":"Urology"},{"key":"R9-20240829","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s00345-015-1645-x","article-title":"Differences between intrinsic and extrinsic ureteropelvic junction obstruction related to crossing vessels:Histology and functional analyses","volume":"34","author":"Ellerkamp","year":"2016","journal-title":"World J Urol"},{"key":"R10-20240829","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1016\/j.juro.2008.05.055","article-title":"Further experience with the vascular hitch (laparoscopic transposition of lower pole crossing vessels):An alternate treatment for pediatric ureterovascular ureteropelvic junction obstruction","volume":"180","author":"Gundeti","year":"2008","journal-title":"J Urol"},{"key":"R11-20240829","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1055\/s-0040-1713177","article-title":"Laparoscopic vascular hitch for polar vessels in pyeloureteric junction obstruction:Medium-term follow-up of a monocentric experience","volume":"31","author":"Al-Emadi","year":"2021","journal-title":"Eur J Pediatr Surg"},{"key":"R12-20240829","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jpurol.2014.10.014","article-title":"Hydronephrosis:Comparison of extrinsic vessel versus intrinsic ureteropelvic junction obstruction groups and a plea against the vascular hitch procedure","volume":"11","author":"Menon","year":"2015","journal-title":"J Pediatr Urol"},{"key":"R13-20240829","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1097\/01.ju.0000169158.86418.46","article-title":"Renal pelvis cuff pyeloplasty for ureteropelvic junction obstruction for the high inserting ureter:An initial experience","volume":"174","author":"Palmer","year":"2005","journal-title":"J Urol"}],"container-title":["African Journal of Paediatric Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.4103\/ajps.ajps_42_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:49:26Z","timestamp":1782953366000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.4103\/ajps.ajps_42_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,19]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ajps.ajps_42_22","relation":{},"ISSN":["0189-6725","0974-5998"],"issn-type":[{"value":"0189-6725","type":"print"},{"value":"0974-5998","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,19]]},"assertion":[{"value":"2022-03-19","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-09","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}