{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T01:44:25Z","timestamp":1782956665265,"version":"3.54.5"},"reference-count":34,"publisher":null,"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Gastrointestinal perforation (GIP) during the neonatal period is still a significant problem despite improved neonatal care. The study aimed to report on incidence, management, morbidity and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>Records of neonates with GIPs between October 2018 and November 2022 were retrospectively analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were 47 patients, 22 (46.8%) males and 25 (53.2%) females. The incidence of neonatal GIP was 0.39% amongst all newborns treated in the neonatal intensive care unit. The mean gestational age was 30.4 \u00b1 4.5 (23\u201338) weeks, and the mean birth weight was 1493.08 \u00b1 753 (580\u20132940) g. Of 47 neonates, 5 (10.6%) were full term and 42 (89.4%) were preterm. The mean age of surgery was 12.25 \u00b1 9.89 (0\u201341) days. A laparotomy was performed in 43 (91.4%) of 47 neonates, while seven of the patients underwent surgical intervention after decompression by percutaneous drainage. Four patients were managed with peritoneal drainage alone due to poor general condition. The pathologies unrelated to necrotising enterocolitis (NEC) were the most common cause of GIPs (55.3%) and included spontaneous intestinal perforation (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 18), stomach perforation (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 4), segmental volvulus (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 2), acute mesenteric ischaemia (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 1) and meconium peritonitis (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 1). Overall survival was 55.4%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>GIPs are one of the most significant causes of mortality in newborns. The most common cause of perforations is non-NEC entities and can be seen in the entire intestinal system from the stomach to the colon. Surgical exploration is still the primary management model.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ajps.ajps_96_23","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T07:19:25Z","timestamp":1725952765000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Neonatal Gastrointestinal Perforations: A 4-year Experience in a Single Centre"],"prefix":"10.67481","author":[{"given":"Gonca","family":"Ger\u00e7el","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, \u015eanl\u0131urfa Training and Research Hospital, \u015eanl\u0131urfa, Turkey"},{"name":"Department of Pediatric Surgery, \u0130stanbul Sancaktepe \u015eehit Prof. Dr. \u0130lhan Varank Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Ihsan","family":"Anadolulu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Mehmet Akif \u0130nan Training and Research Hospital, \u015eanl\u0131urfa, Turkey"},{"name":"Department of Pediatric Surgery, Faculty of Medicine, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul Medeniyet University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":null,"published-online":{"date-parts":[[2024,9,7]]},"reference":[{"key":"R1-20240910","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3345\/kjp.2015.58.8.288","article-title":"Comparison of gastric and other bowel perforations in preterm infants:A review of 20 years'experience in a single institution","volume":"58","author":"Lee","year":"2015","journal-title":"Korean J Pediatr"},{"key":"R2-20240910","first-page":"335","article-title":"Surgical approach to neonatal intestinal perforation. 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