{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:28:28Z","timestamp":1787761708771,"version":"build-2784847793"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION:<\/jats:title>\n                    <jats:p>The coronavirus disease 2019 (COVID-19) has been shown to be a systemic disease affecting different organs of the body including hemostatic system. We aimed to see the utility of thromboelastography (TEG), a global viscoelastic test, in assessing hemostatic profile in COVID-19 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Laboratory records and relevant clinical profiles of our hospitalized COVID-19 patients who underwent TEG testing over a 1-year period were retrospectively studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Out of 103 patients analyzed hypercoagulability was observed on TEG in 49 (48%) patients which was due to hyperfibrinogenemia with hypofibrinolysis and it persisted till 32\u201356 days in a subset of recovered patients. Patients with hypercoagulable profile had higher clotting index (CI), maximum amplitude (MA), \u03b1-angle and lower\n                      <jats:italic toggle=\"yes\">K<\/jats:italic>\n                      values, which correlated with plasma fibrinogen levels and platelet counts. Hypocoagulable TEG profile was observed in 10 (9%) patients out of which, seven had platelet hypocoagulability and three had plasmatic hypocoagulability. Those with hypocoagulable profile had statistically significant lower platelet counts, higher values of\n                      <jats:italic toggle=\"yes\">R<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">K<\/jats:italic>\n                      , and lower values of angle, MA, and CI. Two patients with thrombocytopenia and normocoagulable TEG tracing had co-infection with dengue virus. Lesser recovery rate was observed in patients with hypocoagulable profile compared to those with hypercoagulable and normocoagulable profiles.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>The present study confirmed significant hypercoagulability on TEG in almost half of the patients with COVID-19 despite anticoagulant therapy which was not detectable by conventional coagulation tests. It is plausible that the initial presentation for most of COVID-19 patients was that of hypercoagulable profile which eventually progressed to a hypocoagulable profile in a subset of patients with poorer prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ajts.ajts_133_24","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T10:02:06Z","timestamp":1753696926000},"page":"43-49","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Thromboelastographic insights into hemostatic alterations in coronavirus disease 2019 (COVID-19) patients"],"prefix":"10.4103","volume":"20","author":[{"given":"Anupam","family":"Verma","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, 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