{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:35:50Z","timestamp":1787070950491,"version":"build-2736575974"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>INTRODUCTION:<\/jats:title>\n                    <jats:p>Anemia is one of the leading causes of deferral from blood donation. Classically, an individual\u2019s iron status is assessed with respect to serum ferritin (S. ferritin) levels. S. ferritin levels vary with phases of the menstrual cycle and may not reflect the actual iron stores. Currently, there are certain studies that explain the role of Vitamin D in erythropoiesis. The present study was conducted to assess the emerging association of Vitamin D with hemoglobin (Hb) levels among the female blood donor population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>A hospital-based cross-sectional study was conducted on 111 female blood donors over 1 year. The association of Hb levels with Vitamin D and S. ferritin levels, dietary factors, frequency of blood donations, and the number of pregnancies was analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      The prevalence of Vitamin D deficiency was 80.18% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 89) in this study. Among donors with low Hb levels, 24.32% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 27) had low ferritin and 51.34% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 57) had low Vitamin D levels. 18.01% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 20) of the donors had low Hb levels with coexistent low ferritin and low Vitamin D levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>It is imperative to replenish the iron stores of blood donors who face deferral from blood donation due to low Hb levels. This is a preliminary study from India which looks into the Hb levels of female donors with regard to their Vitamin D status. Those females who were found to be deficient in Hb and Vitamin D levels were referred to treating clinicians for supplementation and dietary modifications. The major goal of this study was to bring those women who got deferred due to low Hb levels back to the voluntary blood donor pool once they replenished their iron stores.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ajts.ajts_13_22","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T12:07:52Z","timestamp":1751371672000},"page":"17-22","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["A pilot study to assess Vitamin D and serum ferritin levels among prospective female blood donors with low hemoglobin levels"],"prefix":"10.4103","volume":"19","author":[{"given":"Anila","family":"Mani","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amita Radhakrishnan","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debasish","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"R1-20260422","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1017\/S1368980008002401","article-title":"Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993\u20132005","volume":"12","author":"McLean","year":"2009","journal-title":"Public Health Nutr"},{"key":"R2-20260422","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/bjh.15136","article-title":"How do we manage iron deficiency after blood donation?","volume":"181","author":"Kiss","year":"2018","journal-title":"Br J Haematol"},{"key":"R3-20260422","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/j.1537-2995.2011.03401.x","article-title":"Iron deficiency in blood donors: The REDS-II Donor Iron Status Evaluation (RISE) study","volume":"52","author":"Cable","year":"2012","journal-title":"Transfusion"},{"key":"R5-20260422","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1537-2995.2011.03062.x","article-title":"Iron deficiency in whole blood donors","volume":"51","author":"Brittenham","year":"2011","journal-title":"Transfusion"},{"key":"R6-20260422","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1136\/gut.2010.228874","article-title":"Guidelines for the management of iron deficiency anaemia","volume":"60","author":"Goddard","year":"2011","journal-title":"Gut"},{"key":"R7-20260422","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1111\/j.1537-2995.2004.04160.x","article-title":"Quantifying losses to the donated blood supply due to donor deferral and miscollection","volume":"44","author":"Custer","year":"2004","journal-title":"Transfusion"},{"key":"R9-20260422","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/MED.0000000000000199","article-title":"Vitamin D and anemia: Insights into an emerging association","volume":"22","author":"Smith","year":"2015","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"R10-20260422","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s12291-014-0449-x","article-title":"The role of 25-hydroxy Vitamin D deficiency in iron deficient children of North India","volume":"30","author":"Sharma","year":"2015","journal-title":"Indian J Clin Biochem"},{"key":"R11-20260422","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1681\/ASN.2013040355","article-title":"Suppression of iron-regulatory hepcidin by Vitamin D","volume":"25","author":"Bacchetta","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"R12-20260422","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D Deficiency","volume":"357","author":"Michael","year":"2007","journal-title":"N Engl J Med"},{"key":"R13-20260422","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/MED.0000000000000199","article-title":"Vitamin D and anemia: insights into an emerging association","volume":"22","author":"Smith","year":"2015","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"R14-20260422","first-page":"7","article-title":"The effect of iron on Vitamin D level in children with combined iron and Vitamin D deficiency","volume":"7","author":"Rostampour","year":"2019","journal-title":"J Parathyr Dis"},{"key":"R15-20260422","first-page":"2018","article-title":"Evolution of hypovitaminosis D among Libyan blood donors (18\u201355 Years Old) attending maternity hospital for donation","volume":"9","author":"Ayad","year":"2020","journal-title":"Int J Sci Res"},{"key":"R16-20260422","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12902-018-0296-5","article-title":"Vitamin D status in healthy black African adults at a tertiary hospital in Nairobi, Kenya: A cross sectional study","volume":"18","author":"Kagotho","year":"2018","journal-title":"BMC Endocr Disord"},{"key":"R17-20260422","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12937-020-0526-3","article-title":"The effect of Vitamin D supplementation on hemoglobin concentration: A systematic review and meta-analysis","volume":"19","author":"Arabi","year":"2020","journal-title":"Nutr J"},{"key":"R18-20260422","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1590\/S1516-31802001000400003","article-title":"Iron deficiency in blood donors","volume":"119","author":"Can\u00e7ado","year":"2001","journal-title":"Sao Paulo Med J"},{"key":"R19-20260422","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1136\/adc.61.9.843","article-title":"Combined deficiency of iron and Vitamin D in Asian toddlers","volume":"61","author":"Grindulis","year":"1986","journal-title":"Arch Dis Child"},{"key":"R20-20260422","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/trf.12380","article-title":"Iron deficiency in Canadian blood donors","volume":"54","author":"Goldman","year":"2014","journal-title":"Transfusion"},{"key":"R21-20260422","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1007\/s00198-009-0954-6","article-title":"Global Vitamin D status and determinants of hypovitaminosis D","volume":"20","author":"Mithal","year":"2009","journal-title":"Osteoporos Int"},{"key":"R22-20260422","doi-asserted-by":"crossref","first-page":"324","DOI":"10.4103\/jfmpc.jfmpc_78_18","article-title":"Vitamin D deficiency in India","volume":"7","author":"Aparna","year":"2018","journal-title":"J Family Med Prim Care"},{"key":"R23-20260422","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/03014460.2018.1425479","article-title":"Prevalence of Vitamin D deficiency and its associated factors among the urban elderly population in Hyderabad metropolitan city, South India","volume":"45","author":"Suryanarayana","year":"2018","journal-title":"Ann Hum Biol"},{"key":"R24-20260422","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1093\/ajcn\/58.5.705","article-title":"Variations in iron-status measures during the menstrual cycle","volume":"58","author":"Kim","year":"1993","journal-title":"Am J Clin Nutr"},{"key":"R25-20260422","doi-asserted-by":"crossref","first-page":"e0213260","DOI":"10.1371\/journal.pone.0213260","article-title":"The association of serum 25-hydroxyvitamin D concentrations with elevated serum ferritin levels in normal weight, overweight and obese Canadians","volume":"14","author":"Munasinghe","year":"2019","journal-title":"PLoS One"},{"key":"R26-20260422","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.0021-8774.2005.00541.x","article-title":"Book reviews: Book reviews","volume":"50","author":"Hewison","year":"2005","journal-title":"J Anal Psychol"},{"key":"R27-20260422","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/jca.20107","article-title":"Severe citrate toxicity complicating volunteer apheresis platelet donation","volume":"22","author":"Bell","year":"2007","journal-title":"J Clin Apher"}],"container-title":["Asian Journal of Transfusion Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ajts.ajts_13_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:39:28Z","timestamp":1787067568000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ajts.ajts_13_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,12]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ajts.ajts_13_22","relation":{},"ISSN":["0973-6247","1998-3565"],"issn-type":[{"value":"0973-6247","type":"print"},{"value":"1998-3565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,12]]},"assertion":[{"value":"2022-01-19","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-02","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}