{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:31:16Z","timestamp":1786649476521,"version":"build-2736575974"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Donor physiognomic characteristics play a critical role in determining the quality of packed red cell units (PRBCs), which directly impacts transfusion outcomes. This retrospective study aimed to evaluate the influence of donor physiognomic factors on PRBC quality at a tertiary care transfusion center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on 250 randomly selected blood donors from January 2015 to August 2018. Donor age, gender, weight, and predonation hemoglobin (PHB) levels were assessed, along with PRBC parameters including volume (350 ml vs. 450 ml), processing method, PRBC age, and percent hemolysis during storage. Subsequent evaluations included hematocrit, per unit total hemoglobin (UTHB), and red cell mass.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      The mean weight among donors aged 18\u201328 years was 69.8 kg, compared to 74.46 kg in higher age groups. Lower PHB levels (12.5\u201313.0 g\/dL) were associated with decreased UTHB. PRBCs prepared using the buffy coat method exhibited lower mean UTHB compared to other methods. A significant correlation (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01) was observed between PRBC age and hemolysis in all units.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Donor PHB significantly influences the quality of PRBCs prepared, with lower PHB levels correlating with decreased UTHB. PRBCs prepared using the buffy coat method showed inferior UTHB, and older PRBC units displayed higher red cell hemolysis. However, donor gender, age, and weight did not significantly affect PRBC quality in this study. Larger sample sizes are necessary to confirm these findings. These results highlight the importance of donor screening and selection to optimize PRBC quality and enhance transfusion therapy outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ajts.ajts_144_24","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T12:07:32Z","timestamp":1751371652000},"page":"36-41","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the influence of donor physiognomic factors on packed red cell unit quality: A retrospective analysis from a tertiary care transfusion center"],"prefix":"10.4103","volume":"19","author":[{"given":"P.","family":"Nagaraju","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Homi Bhabha National Institute, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashank","family":"Ojha","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Homi Bhabha National Institute, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suryatapa","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Tata Memorial Centre, Homi Bhabha National Institute, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"R1-20260422","first-page":"585","article-title":"Transfusion of Blood and Blood Products","author":"Marik","year":"2014","journal-title":"Evid Based Crit Care"},{"key":"R2-20260422","doi-asserted-by":"crossref","first-page":"122","DOI":"10.4103\/0973-6247.187938","article-title":"Blood donor selection and deferral pattern as an important tool for blood safety in a tertiary care hospital","volume":"10","author":"Shrivastava","year":"2016","journal-title":"Asian J Transfus Sci"},{"key":"R3-20260422","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/jca.20257","article-title":"Evidence-based selection criteria to protect blood donors","volume":"25","author":"Eder","year":"2010","journal-title":"J Clin Apher"},{"key":"R4-20260422","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1159\/000362896","article-title":"Assessment of impact of training in improving knowledge of blood transfusion among clinicians","volume":"41","author":"Kaur","year":"2014","journal-title":"Transfus Med Hemother"},{"key":"R5-20260422","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.tmrv.2016.01.002","article-title":"Effect of blood donor characteristics on transfusion outcomes: A systematic review and meta-analysis","volume":"30","author":"Chass\u00e9","year":"2016","journal-title":"Transfus Med Rev"},{"key":"R6-20260422","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.tracli.2021.08.001","article-title":"Impact of blood donor characteristics on quality of packed red blood cell concentrates","volume":"29","author":"Mittal","year":"2022","journal-title":"Transfus Clin Biol"},{"key":"R7-20260422","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s10877-022-00877-3","article-title":"Does the age of packed red blood cells, donor sex or sex mismatch affect the sublingual microcirculation in critically ill intensive care unit patients? A secondary interpretation of a retrospective analysis","volume":"37","author":"Knobel","year":"2023","journal-title":"J Clin Monit Comput"},{"key":"R8-20260422","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1111\/trf.17471","article-title":"Quality assessment of red blood cell concentrates from blood donors at the extremes of the age spectrum: The best collaborative study","volume":"63","author":"Cloutier","year":"2023","journal-title":"Transfusion"},{"key":"R9-20260422","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.clp.2023.08.001","article-title":"Blood donor sex and outcomes in transfused infants","volume":"50","author":"Salem","year":"2023","journal-title":"Clin Perinatol"},{"key":"R10-20260422","first-page":"520","article-title":"The need to label red blood cell units with their haemoglobin content: A single centre study on haemoglobin variations due to donor-related factors","volume":"12","author":"Agnihotri","year":"2014","journal-title":"Blood Transfus"},{"key":"R11-20260422","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.14260\/jemds\/2016\/282","article-title":"Quality analysis of blood component (PRBC and platelet concentrates): A study from a tertiary care teaching hospital of Kumaon region of Uttarakhand","volume":"5","author":"Upadhyay","year":"2016","journal-title":"J Evol Med Dent Sci"},{"key":"R12-20260422","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/j.1423-0410.2009.01285.x","article-title":"Capillary and venous haemoglobin levels in blood donors: A 42-month study of 36,258 paired samples","volume":"98","author":"Tong","year":"2010","journal-title":"Vox Sang"},{"key":"R13-20260422","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S1246-7820(03)00032-6","article-title":"In vitro quality control of red blood cell concentrates outdated in clinical practice","volume":"10","author":"Zimmermann","year":"2003","journal-title":"Transfus Clin Biol"},{"key":"R14-20260422","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/nyas.14139","article-title":"Hemoglobin concentration and anemia diagnosis in venous and capillary blood: Biological basis and policy implications","volume":"1450","author":"Neufeld","year":"2019","journal-title":"Ann N Y Acad Sci"},{"key":"R15-20260422","first-page":"116","article-title":"Red blood cell components: Time to revisit the sources of variability","volume":"15","author":"Sparrow","year":"2017","journal-title":"Blood Transfus"},{"key":"R16-20260422","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/tme.12725","article-title":"Inter-donor variability in deformability of red blood cells in blood units","volume":"30","author":"Barshtein","year":"2020","journal-title":"Transfus Med"},{"key":"R17-20260422","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1001\/jamainternmed.2016.3324","article-title":"Association of blood donor age and sex with recipient survival after red blood cell transfusion","volume":"176","author":"Chass\u00e9","year":"2016","journal-title":"JAMA Intern Med"},{"key":"R18-20260422","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1001\/jamainternmed.2016.3355","article-title":"Blood donor demographics and transfusion recipient survival-no country for old men?","volume":"176","author":"Klein","year":"2016","journal-title":"JAMA Intern Med"},{"key":"R19-20260422","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1007\/s00134-015-4078-5","article-title":"Effects of packed red blood cell storage duration on post-transfusion clinical outcomes: A meta-analysis and systematic review","volume":"41","author":"Ng","year":"2015","journal-title":"Intensive Care Med"},{"key":"R20-20260422","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/j.1537-2995.2004.03315.x","article-title":"Visual assessment of hemolysis in red blood cell units and segments can be deceptive","volume":"44","author":"Janatpour","year":"2004","journal-title":"Transfusion"},{"key":"R21-20260422","first-page":"222","article-title":"Red blood cell storage time and transfusion: Current practice, concerns and future perspectives","volume":"15","author":"Garc\u00eda-Roa","year":"2017","journal-title":"Blood Transfus"}],"container-title":["Asian Journal of Transfusion Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ajts.ajts_144_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:54:37Z","timestamp":1786647277000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ajts.ajts_144_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ajts.ajts_144_24","relation":{},"ISSN":["0973-6247","1998-3565"],"issn-type":[{"value":"0973-6247","type":"print"},{"value":"1998-3565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-08-25","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-22","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}