{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:26:30Z","timestamp":1787775990550,"version":"build-2784847793"},"reference-count":5,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Splenic infarction is a rare entity in pediatric population and is associated with predisposing conditions, i.e., hematological and oncological or infections. Among hematological conditions, only few cases associated with autoimmune hemolytic anemia (AIHA) have been reported so far. We encountered a 12-year-old female who presented with left upper quadrant pain and was diagnosed as AIHA with splenic infarction. Further workup revealed decreased protein S levels \u221263% (normal: 74%\u2013146%); no laboratory parameters were suggestive of any clinical condition, leading to decreased protein S levels. Few cases of protein C deficiency with splenic infraction have been reported in patients with leukemia, hereditary spherocytosis, and Epstein\u2013Barr virus infection, but to the best of our knowledge, no one has reported AIHA with splenic infarction with protein S deficiency so far.<\/jats:p>","DOI":"10.4103\/ajts.ajts_150_22","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T15:01:52Z","timestamp":1760799712000},"page":"358-361","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A rare case of autoimmune hemolytic anemia with protein S deficiency with splenic infarct"],"prefix":"10.4103","volume":"19","author":[{"given":"Afreen","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Hamdard Institute of Medical Sciences and Research, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Twisha","family":"Ishani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hamdard Institute of Medical Sciences and Research, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishaq","family":"Farooq","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hamdard Institute of Medical Sciences and Research, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devki","family":"Nandan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hamdard Institute of Medical Sciences and Research, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shohrab","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hamdard Institute of Medical Sciences and Research, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,8,2]]},"reference":[{"key":"R1-20251022","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ajem.2008.02.014","article-title":"Splenic infarction:10 years of experience","volume":"27","author":"Antopolsky","year":"2009","journal-title":"Am J Emerg Med"},{"key":"R2-20251022","first-page":"286","article-title":"Acquired hemolytic anemia with infarct of the spleen;splenectomy;recovery","volume":"67","author":"Tzanck","year":"1951","journal-title":"Bull Mem Soc Med Hop Paris"},{"key":"R3-20251022","doi-asserted-by":"crossref","first-page":"274","DOI":"10.5045\/kjh.2011.46.4.274","article-title":"Splenic infarction in a patient with autoimmune hemolytic anemia and protein C deficiency","volume":"46","author":"Park","year":"2011","journal-title":"Korean J Hematol"},{"key":"R4-20251022","doi-asserted-by":"crossref","first-page":"623","DOI":"10.4269\/ajtmh.21-0943","article-title":"Case report:Splenic infarction in infectious mononucleosis due to Epstein-Barr virus infection","volume":"106","author":"Nishioka","year":"2021","journal-title":"Am J Trop Med Hyg"},{"key":"R5-20251022","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1111\/j.1365-2516.2008.01775.x","article-title":"Protein S deficiency:A clinical perspective","volume":"14","author":"ten","year":"2008","journal-title":"Haemophilia"}],"container-title":["Asian Journal of Transfusion Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ajts.ajts_150_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:47:58Z","timestamp":1787773678000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ajts.ajts_150_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,2]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ajts.ajts_150_22","relation":{},"ISSN":["0973-6247","1998-3565"],"issn-type":[{"value":"0973-6247","type":"print"},{"value":"1998-3565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,2]]},"assertion":[{"value":"2022-11-19","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-30","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}