{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:09:47Z","timestamp":1792062587227,"version":"4.4.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>The diagnosis of hepatitis B infection in most blood transfusion centers is based on hepatitis B surface (HBs) antigen detection by an enzyme immunoassay method. This study aimed to determine the frequency of hepatitis B core (HBc) antibody, HBs antibody, and hepatitis B virus (HBV) DNA among HBs antigen-negative healthy blood donors of Yazd province, Iran.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>This cross-sectional study was conducted on 1500 healthy blood donor samples negative for HBs antigen, hepatitis C virus antibody, human immunodeficiency virus antigen\/antibody, and rapid plasma regain tests. All samples were screened for HBc antibody test. HBs antibody and real-time polymerase chain reaction were performed for HBc antibody-positive samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>HBc antibody was positive in 74 (4.9%) samples and 11 (14.9%) of 74 positive samples for HBc antibody were negative for HBs antibody. Sixty-three (85.1%) positive samples for HBc antibody had HBs antibody titer over 10 IU\/L, and 43 (58.1%) had HBs antibody titer over 100 IU\/L. There was no hepatitis B DNA-positive sample in the present study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>The study results suggest that there is a very low risk for transmission of HBV through blood donors of Yazd, Iran.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ajts.ajts_155_18","type":"journal-article","created":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T10:40:33Z","timestamp":1636281633000},"page":"179-182","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Frequency of hepatitis B virus-DNA among hepatitis B surface-Ag negative, anti-hepatitis B core antibody-positive blood donors in Yazd, Iran"],"prefix":"10.4103","volume":"15","author":[{"given":"Mahtab","family":"Vaziri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayedeh Javadzadeh","family":"Shahshahani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-11-20240830","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1423-0410.2008.01017.x","article-title":"Occult hepatitis B infection in blood donors","volume":"94","author":"Reesink","year":"2008","journal-title":"Vox Sang"},{"key":"R2-11-20240830","first-page":"199","article-title":"Occult hepatitis B infection in chronic hemodialysis patients: current concepts and strategy","volume":"10","author":"Hollinger","year":"2010","journal-title":"Hepat Monday"},{"key":"R3-11-20240830","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1373\/clinchem.2006.072504","article-title":"Hepatitis B surface antigen (HBsAg) assays \u2013 Are they good enough for their current uses?","volume":"52","author":"Dufour","year":"2006","journal-title":"Clin Chem"},{"key":"R4-11-20240830","first-page":"1","article-title":"Frequency of anti-HBc&HBV DNA detection in blood donors of Kerman province, Iran","volume":"2","author":"Delavari","year":"2011","journal-title":"J Blood Disord Transfus"},{"key":"R5-11-20240830","doi-asserted-by":"crossref","first-page":"e308","DOI":"10.1016\/j.ijid.2009.05.011","article-title":"Lack of occult hepatitis B virus infection among blood donors with isolated hepatitis B core antibody living in an HBV low prevalence region of Iran","volume":"14","author":"Sofian","year":"2010","journal-title":"Int J Infect Dis"},{"key":"R6-11-20240830","first-page":"27","article-title":"Occult hepatitis B virus infection among blood donors with antibodies to hepatitis B core antigen","volume":"46","author":"Jafarzadeh","year":"2008","journal-title":"Acta Med 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