{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:19:44Z","timestamp":1787847584875,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n                  <jats:p>In post-transplant phase, liver transplant (LT) recipients may experience anemia or hemolysis due to various immune or non-immune reasons and require prompt intervention and timely management. One such instance is when recipients of minor ABO-incompatible LT (ABOiLT) experience delayed hemolysis mediated by lymphocytes present in the graft known as passenger lymphocyte syndrome (PLS). We present a case report of a PLS in a 6-month-old child who underwent ABOiLT. On postoperative day 14, there was a drop in patient\u2019s hemoglobin, and anti-human globulin crossmatch was incompatible with recipient group (A positive) red cells. No standardized consensus exists on screening for PLS in post-LT recipients. In transplant settings, it is imperative to streamline the workflow for timely recognition and management of PLS early to prevent adverse outcomes and minimize invasive therapy. We present this case of PLS in a post-LT child to highlight the need for right algorithm of immuno-hematological workup in case of post-transplant hemolysis.<\/jats:p>","DOI":"10.4103\/ajts.ajts_166_24","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T10:01:43Z","timestamp":1753696903000},"page":"232-235","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Passenger lymphocyte syndrome: Need for consensus on transfusion guidelines and direct anti-globulin test screening in post-liver transplantation period"],"prefix":"10.4103","volume":"20","author":[{"given":"V. M. Jyotsnaa","family":"Grace","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine, Dr. Rela Institute and Medical Centre, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Deepthi","family":"Krishna","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Dr. Rela Institute and Medical Centre, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepti","family":"Sachan","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Dr. Rela Institute and Medical Centre, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"R1-20260529","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1097\/MOH.0b013e3282e9a576","article-title":"Immune hemolysis following ABO-mismatched stem cell or solid organ transplantation","volume":"14","author":"Yazer","year":"2007","journal-title":"Curr Opin Hematol"},{"key":"R2-20260529","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s12288-018-0971-8","article-title":"Passenger lymphocyte syndrome following minor ABO mismatch liver transplantation","volume":"34","author":"Sachan","year":"2018","journal-title":"Indian J Hematol Blood Transfus"},{"key":"R3-20260529","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.tmrv.2020.06.004","article-title":"Passenger lymphocyte syndrome;a review of the diagnosis, treatment, and proposed detection protocol","volume":"34","author":"Moosavi","year":"2020","journal-title":"Transfus Med Rev"},{"key":"R4-20260529","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1046\/j.1537-2995.1989.29589284137.x","article-title":"Red cell antibody problems in 1000 liver transplants","volume":"29","author":"Ramsey","year":"1989","journal-title":"Transfusion"},{"key":"R5-20260529","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1053\/j.seminhematol.2005.05.017","article-title":"Immune hemolysis associated with transplantation","volume":"42","author":"Petz","year":"2005","journal-title":"Semin Hematol"},{"key":"R6-20260529","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/lt.20031","article-title":"Post-liver-transplant anemia:Etiology and management","volume":"10","author":"Maheshwari","year":"2004","journal-title":"Liver Transpl"},{"key":"R7-20260529","doi-asserted-by":"crossref","first-page":"e00845","DOI":"10.14309\/crj.0000000000000845","article-title":"Liver failure in neonates with G6PD deficiency","volume":"9","author":"Shah","year":"2022","journal-title":"ACG Case Rep J"},{"key":"R8-20260529","doi-asserted-by":"crossref","DOI":"10.1111\/ctr.13031","article-title":"Autoimmune hemolytic anemia in solid organ transplantation-The role of immunosuppression","volume":"31","author":"Kanellopoulou","year":"2017","journal-title":"Clin Transplant"},{"key":"R9-20260529","first-page":"423","article-title":"Passenger lymphocyte syndrome in liver transplant recipients:A description of 12 cases","volume":"13","author":"Romero","year":"2015","journal-title":"Blood Transfus"}],"container-title":["Asian Journal of Transfusion Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ajts.ajts_166_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:22:58Z","timestamp":1787844178000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ajts.ajts_166_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,22]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ajts.ajts_166_24","relation":{},"ISSN":["0973-6247","1998-3565"],"issn-type":[{"value":"0973-6247","type":"print"},{"value":"1998-3565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,22]]},"assertion":[{"value":"2024-10-06","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-17","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}