{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:28:18Z","timestamp":1787761698324,"version":"build-2784847793"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n                  <jats:p>Presence of antibodies directed against certain red cell antigens in a solid organ transplant recipient can complicate transplant outcome if the donor is positive for those antigen(s). Therefore, these are immunohematological barriers that affect clinical decisions taken in such scenarios. Case A: A 43 year old woman who was a case of chronic kidney disease (CKD). She was on dialysis while awaiting a renal transplant. During her pre-transplant workup, she was found to have anti-Jka and anti-e antibodies making it a challenging scenario. She was listed as a prospective match for a cadaver kidney. Complement dependant Cytotoxicity (CDC) cross-match was negative. But an additional typing was requested for the donor. When found to be Jka-, the next concern arose for any possible blood requirement during the transplant due to her anti-e antibody. Since the required units would have to be Jka-e-, a rare phenotype, it was decided to not allocate the current organ, put her back on dialysis and suitably prepare for the transplant by taking the time to correct her anemia, decide on a suitable operative strategy to minimize blood loss and attempt to arrange antigen negative units for her before the surgery. Case B: A 64 year old female patient suffered from non-alcoholic steatohepatitis(NASH) and was being considered for liver transplant from her son. However routine immunohematological testing before the transplant showed she had anti- Fya antibodies and was Fya-. Her liver donor was Fya+, but all the anticipated required red cell units needed to be Fya-. A total of 56 units were cross-matched to find 5 compatible units. Her surgery was uneventful and she required 3 units of those PRBCs during it. Red cell antigen systems should be taken into consideration in transplantations, atleast on a case-to-case basis, if not routinely, especially in the context of peri-transplant transfusion needs.<\/jats:p>","DOI":"10.4103\/ajts.ajts_167_24","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T10:02:04Z","timestamp":1753696924000},"page":"208-212","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Red blood cell alloantibodies dictating solid organ transplant decisions: Two case reports"],"prefix":"10.4103","volume":"20","author":[{"given":"Soumee","family":"Banerjee","sequence":"first","affiliation":[{"name":"Rotary TTK Blood Centre, Bangalore Medical Services Trust, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Arpitha","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Gleneagles BGS Hospital, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TV","family":"Reddy","sequence":"additional","affiliation":[{"name":"Rotary TTK Blood Centre, Bangalore Medical Services Trust, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santanu","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Rotary TTK Blood Centre, Bangalore Medical Services Trust, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit","family":"Mathur","sequence":"additional","affiliation":[{"name":"Rotary TTK Blood Centre, Bangalore Medical Services Trust, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"R2-20260529","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1097\/LVT.0000000000000438","article-title":"Improved outcomes of ABO-incompatible living donor liver transplant with biologically related donors","volume":"30","author":"Ranjan","year":"2024","journal-title":"Liver Transpl"},{"key":"R3-20260529","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1097\/00007890-199802270-00026","article-title":"Influence of the Rh (D) blood group system on graft survival in renal transplantation","volume":"65","author":"Bryan","year":"1998","journal-title":"Transplantation"},{"key":"R4-20260529","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1111\/tri.13685","article-title":"The potential role of antibodies against minor blood group antigens in renal transplantation","volume":"33","author":"Holt","year":"2020","journal-title":"Transpl Int"},{"key":"R5-20260529","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1537-2995.2007.01060.x","article-title":"Duffy and Kidd blood group antigens:Minor histocompatibility antigens involved in renal allograft rejection?","volume":"47","author":"Lerut","year":"2007","journal-title":"Transfusion"},{"key":"R6-20260529","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1093\/ndt\/gfh333","article-title":"Acute transplant rejection induced by blood transfusion reaction to the Kidd blood group system","volume":"19","author":"Holt","year":"2004","journal-title":"Nephrol Dial Transplant"},{"key":"R8-20260529","doi-asserted-by":"crossref","first-page":"488","DOI":"10.4103\/ijmr.IJMR_1974_15","article-title":"Red cell alloimmunization &role of advanced immunohaematological support in liver transplantation","volume":"145","author":"Makroo","year":"2017","journal-title":"Indian J Med Res"},{"key":"R9-20260529","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/j.1399-0012.2011.01397.x","article-title":"Blood transfusions in kidney transplant candidates are common and associated with adverse outcomes","volume":"25","author":"Ibrahim","year":"2011","journal-title":"Clin Transplant"},{"key":"R10-20260529","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/vox.12059","article-title":"A UK single-centre survey of red cell antibodies in adult patients undergoing liver transplantation","volume":"105","author":"Mushkbar","year":"2013","journal-title":"Vox Sang"},{"key":"R11-20260529","doi-asserted-by":"crossref","first-page":"1442018","DOI":"10.3389\/fgene.2024.1442018","article-title":"Improving long-term kidney allograft survival by rethinking HLA compatibility:From molecular matching to non-HLA genes","volume":"15","author":"Mattoo","year":"2024","journal-title":"Front Genet"},{"key":"R12-20260529","doi-asserted-by":"crossref","first-page":"11725","DOI":"10.3389\/ti.2023.11725","article-title":"The role of the Duffy blood group antigens in renal transplantation and rejection. A mini review","volume":"36","author":"Hariri","year":"2023","journal-title":"Transpl Int"},{"key":"R13-20260529","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1046\/j.1523-1755.2000.00316.x","article-title":"The Duffy antigen receptor for chemokines is up-regulated during acute renal transplant rejection and crescentic glomerulonephritis","volume":"58","author":"Segerer","year":"2000","journal-title":"Kidney Int"},{"key":"R15-20260529","doi-asserted-by":"crossref","first-page":"1440359","DOI":"10.3389\/fneph.2024.1440359","article-title":"Editorial:Non-immunological care of the kidney transplant recipients","volume":"4","author":"Halfon","year":"2024","journal-title":"Front Nephrol"},{"key":"R16-20260529","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1111\/apm.12773","article-title":"Occurrence of five distinct red cell alloantibodies in a renal transplant recipient:Diagnostic and therapeutic implications of minor histocompatibility antigens (Kidd and Duffy) for renal allograft outcome","volume":"125","author":"Subramaniyan","year":"2017","journal-title":"APMIS"},{"key":"R17-20260529","doi-asserted-by":"crossref","first-page":"94","DOI":"10.4103\/0973-6247.150966","article-title":"Approach to a case of multiple irregular red cell antibodies in a liver transplant recipient:Need for developing competence","volume":"9","author":"Dara","year":"2015","journal-title":"Asian J Transfus Sci"}],"container-title":["Asian Journal of Transfusion Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ajts.ajts_167_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:03:20Z","timestamp":1787760200000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ajts.ajts_167_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,22]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ajts.ajts_167_24","relation":{},"ISSN":["0973-6247","1998-3565"],"issn-type":[{"value":"0973-6247","type":"print"},{"value":"1998-3565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,22]]},"assertion":[{"value":"2024-10-07","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-30","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}