{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:39:21Z","timestamp":1786649961487,"version":"build-2736575974"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Red cell exchange is important to treat acutely ill sickle cell patients, but it is time-consuming. An automated red cell exchange technique using cell separators developed by different manufacturers helps in removal of sickled hemoglobin and improving blood viscosity. The use of these cell separators permits automated red cell exchange to be performed safely and smoothly with the isovolemic hemodilution. The retrospective analysis of seven cases for automated red cell exchange was performed in IMS and SUM Hospital from September, 2019 to July 2021. One procedure was performed on COBE Spectra Apheresis System and the rest six using Spectra Optia Apheresis System. These procedures were performed on the patients and the decision to perform these procedures was based on clinical indications for red cell exchange following the ASFA guidelines 2019. After only one procedure, all the patients have their sickle hemoglobin reduced to a safe level. End hematocrit was observed to be 33% in three cases, 31.9% in one case, and 30% in the rest three. A total number of red blood cells (RBCs) transfusion in all the cases were 7, 6, 8, 5, 6, 7, and 7 with an average hematocrit of 55%, 56%, 54%, 56%, 55%, 51.7%, and 52.2%, respectively. All the patients partially phenotypically matched, leukoreduced, gamma-irradiated, fresh packed RBCs were provided. Automated red cell exchange came out to be successful in reducing the symptoms along with the improvement in laboratory parameters. New-generation automated apheresis equipment like Spectra Optia, the case series provides better monitoring and also reduces apheresis-related complications.<\/jats:p>","DOI":"10.4103\/ajts.ajts_174_21","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T12:24:08Z","timestamp":1734956648000},"page":"350-354","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Automated red cell exchange in sickle cell disease patients: Retrospective analysis of series of cases in a tertiary care hospital in Eastern India"],"prefix":"10.4103","volume":"18","author":[{"given":"Girijanandini","family":"Kanungo","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine, IMS and SUM Hospital, Siksha \u2018O\u2019 Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Nagrath","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, IMS and SUM Hospital, Siksha \u2018O\u2019 Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Samal","sequence":"additional","affiliation":[{"name":"Department of Clinical Hematology, IMS and SUM Hospital, Siksha \u2018O\u2019 Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, IMS and SUM Hospital, Siksha \u2018O\u2019 Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"R1-20241224","doi-asserted-by":"crossref","first-page":"17685","DOI":"10.1038\/s41598-018-36077-w","article-title":"The spatial epidemiology of sickle-cell anaemia in India","volume":"8","author":"Hockham","year":"2018","journal-title":"Sci Rep"},{"key":"R2-20241224","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4103\/0971-5916.178582","article-title":"Sickle cell disease in India: A perspective","volume":"143","author":"Serjeant","year":"2016","journal-title":"Indian J Med Res"},{"key":"R3-20241224","first-page":"49","article-title":"Recommendations for the transfusion of red blood cells","volume":"7","author":"Liumbruno","year":"2009","journal-title":"Blood Transfus"},{"key":"R4-20241224","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1159\/000369513","article-title":"Red blood cell alloimmunization in sickle cell disease: Listen to your ancestors","volume":"41","author":"Campbell-Lee","year":"2014","journal-title":"Transfus Med Hemother"},{"key":"R6-20241224","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1182\/asheducation-2006.1.48","article-title":"Red cell exchange in sickle cell disease","volume":"2006","author":"Swerdlow","year":"2006","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"R7-20241224","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.jpeds.2006.06.037","article-title":"Exchange blood transfusion compared with simple transfusion for first overt stroke is associated with a lower risk of subsequent stroke: A retrospective cohort study of 137 children with sickle cell anemia","volume":"149","author":"Hulbert","year":"2006","journal-title":"J Pediatr"},{"key":"R8-20241224","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0002-9343(94)90136-8","article-title":"Acute multiorgan failure syndrome: A potentially catastrophic complication of severe sickle cell pain episodes","volume":"96","author":"Hassell","year":"1994","journal-title":"Am J Med"},{"key":"R9-20241224","doi-asserted-by":"crossref","first-page":"674","DOI":"10.4103\/0972-5229.194017","article-title":"Exchange transfusion for babesiosis when, how, and how long?","volume":"20","author":"Guru","year":"2016","journal-title":"Indian J Crit Care Med"},{"key":"R10-20241224","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/bjh.14346","article-title":"Guidelines on red cell transfusion in sickle cell disease. Part I: Principles and laboratory aspects","volume":"176","author":"Davis","year":"2017","journal-title":"Br J Haematol"},{"key":"R11-20241224","first-page":"303","article-title":"Red cell exchange is not effective for patients with sickle cell anaemia and coexisting warm autoantibody haemolysis","volume":"8","author":"Baron","year":"2010","journal-title":"Blood Transfus"},{"key":"R12-20241224","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s11239-013-0914-z","article-title":"Short-term central venous catheter complications in patients with sickle cell disease who undergo apheresis","volume":"37","author":"Yeral","year":"2014","journal-title":"J Thromb Thrombolysis"}],"updated-by":[{"DOI":"10.4103\/ajts.ajts_163_25","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000}}],"container-title":["Asian Journal of Transfusion Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ajts.ajts_174_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:00:26Z","timestamp":1786647626000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ajts.ajts_174_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,12]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ajts.ajts_174_21","relation":{},"ISSN":["0973-6247","1998-3565"],"issn-type":[{"value":"0973-6247","type":"print"},{"value":"1998-3565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,12]]},"assertion":[{"value":"2021-11-25","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-31","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}