{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:22:29Z","timestamp":1787840549275,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Anti-C\n                    <jats:sup>w<\/jats:sup>\n                    (C Willis) is a low-frequency immunoglobulin against red cell antigen C\n                    <jats:sup>w<\/jats:sup>\n                    in the Rhesus (Rh) blood group system. Anti-C\n                    <jats:sup>w<\/jats:sup>\n                    can either be naturally occurring or develop as a result of red blood cell sensitization through transfusion or during pregnancy, and is rarely associated with clinically significant hemolytic disease of the fetus and newborn. However, anti-C\n                    <jats:sup>w<\/jats:sup>\n                    , being a low-frequency antigen, is not always included in the commercial antibody screening panels and also not phenotyped for in-house pooled red cells used for single-cell indirect antiglobulin testing for blood donors in various blood centers. Here, we report a case of a whole blood donor who was identified with an anti-C\n                    <jats:sup>w<\/jats:sup>\n                    antibody.\n                  <\/jats:p>","DOI":"10.4103\/ajts.ajts_17_23","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T01:01:01Z","timestamp":1707267661000},"page":"346-348","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Reporting a rare, clinically significant, naturally occurring anti-Cw alloantibody in a whole blood donor: A kingpin in vein-to-vein transfusion chain"],"prefix":"10.4103","volume":"19","author":[{"given":"Daljit","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine and Blood Bank, AIIMS, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyisa","family":"Deb","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, Tata Medical Center, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dixa","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine and Blood Bank, AIIMS, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine and Blood Bank, AIIMS, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zikra","family":"Syed","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine and Blood Bank, AIIMS, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gita","family":"Negi","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine and Blood Bank, AIIMS, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"R1-20251022","doi-asserted-by":"crossref","first-page":"872","DOI":"10.3389\/fimmu.2017.00872","article-title":"Defining natural antibodies","volume":"8","author":"Holodick","year":"2017","journal-title":"Front Immunol"},{"key":"R2-20251022","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1056\/NEJM195807312590508","article-title":"Naturally occurring anti-Rh antibody","volume":"259","author":"Allen","year":"1958","journal-title":"N Engl J Med"},{"key":"R3-20251022","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tracli.2022.08.001","article-title":"A rare case of clinically significant naturally occurring anti-C(w) reported in a healthy male donor","volume":"30","author":"Pandey","year":"2023","journal-title":"Transfus Clin Biol"},{"key":"R4-20251022","doi-asserted-by":"crossref","first-page":"99","DOI":"10.4103\/gjtm.gjtm_92_21","article-title":"Rare anti-Cw antibody:Two case reports with review of literature","volume":"7","author":"Mangwana","year":"2022","journal-title":"Glob J Transfus Med"},{"key":"R5-20251022","first-page":"287","article-title":"MAR, a novel high-incidence Rh antigen revealing the existence of an allelic sub-system including Cw (Rh8) and Cx (Rh9) with exceptional distribution in the Finnish population","volume":"66","author":"Sistonen","year":"1994","journal-title":"Vox Sang"},{"key":"R6-20251022","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1469-1809.1946.tb02346.x","article-title":"A serological and genetical study of multiple antibodies formed in response to blood transfusion by a patient with lupus erythematosus diffusus","volume":"13","author":"Callender","year":"1946","journal-title":"Ann Eugen"},{"key":"R7-20251022","first-page":"226","article-title":"Maternal CW alloimmunization","volume":"64","author":"Bowman","year":"1993","journal-title":"Vox Sang"},{"key":"R8-20251022","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1097\/01.AOG.0000164060.89842.a9","article-title":"Severe hemolytic disease of the newborn due to anti-Cw","volume":"106","author":"Byers","year":"2005","journal-title":"Obstet Gynecol"},{"key":"R9-20251022","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1182\/blood-2018-08-833962","article-title":"Transfusion-related red blood cell alloantibodies:Induction and consequences","volume":"133","author":"Tormey","year":"2019","journal-title":"Blood"}],"container-title":["Asian Journal of Transfusion Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ajts.ajts_17_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:24:52Z","timestamp":1787837092000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ajts.ajts_17_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,7]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ajts.ajts_17_23","relation":{},"ISSN":["0973-6247","1998-3565"],"issn-type":[{"value":"0973-6247","type":"print"},{"value":"1998-3565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,7]]},"assertion":[{"value":"2023-01-24","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-19","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}